Association of CD204+ macrophages with poor outcomes of malignant lymphomas not in remission treated by allogeneic HCT

Akihisa Kawajiri, Shigehisa Kitano, Akiko Miyagi Maeshima, Yoshihiro Inamoto, Kinuko Tajima, Tomonari Takemura, Takashi Tanaka, Ayumu Ito, Keiji Okinaka, Saiko Kurosawa, Sung Won Kim, Hirokazu Taniguchi, Chitose Ogawa, Koji Izutsu, Noboru Yamamoto, Takahiro Fukuda

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective: CD204+ tumor-associated macrophages are associated with adverse outcomes of various malignancies. We performed a study to elucidate the role of CD204+ macrophages in allogeneic hematopoietic cell transplantation (allogeneic HCT). Methods: In a total of 81 patients who received allogeneic HCT for non-remission malignant lymphoma, immunohistochemical staining of CD204 using specimens preserved before allogeneic HCT was performed. According to the average number of CD204+ macrophages in a high-power field, patients were categorized into three groups: low (<25th percentile), intermediate (≥25th percentile and <50th percentile), and high (≥50th percentile). Results: The B-cell lymphoma proportion was higher in the low group, while T-cell lymphoma and adult T-cell leukemia proportions were higher in the high group. The 3-year overall survival (OS) was poorest in the high group; low vs intermediate vs high = 83.3% vs 43.7% vs 20.2% (P <.01). The 3-year cumulative incidences of relapse were significantly higher in the high group than the intermediate and low groups: 67.0% vs 38.1% vs 18.2% (P <.01). In multivariate analyses, the numbers of CD204+ macrophages were independent risk factors of poorer OS and cumulative incidences of relapse. Conclusions: CD204+ macrophages might be associated with poorer prognosis in allogeneic HCT for malignant lymphomas.

Original languageEnglish
Pages (from-to)578-587
Number of pages10
JournalEuropean Journal of Haematology
Volume103
Issue number6
DOIs
Publication statusPublished - 01-12-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology

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