Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese

Wael Osman, Yukinori Okada, Yoichiro Kamatani, Michiaki Kubo, Koichi Matsuda, Yusuke Nakamura

Research output: Contribution to journalArticle

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Abstract

We performed a genome-wide association study (GWAS) on levels of serum total protein (TP), albumin (ALB), and non-albumin protein (NAP). We analyzed SNPs on autosomal chromosomes using data from 9,103 Japanese individuals, followed by a replication study of 1,600 additional individuals. We confirmed the previously- reported association of GCKR on chromosome 2p23.3 with serum ALB (rs1260326, Pmeta = 3.1×10-9), and additionally identified the significant genome-wide association of rs4985726 in TNFRSF13B on 17p11.2 with both TP and NAP (Pmeta = 1.2×10-14 and 7.1×10-24, respectively). For NAP, rs3803800 and rs11552708 in TNFSF13 on 17p13.1 (Pmeta = 7.2×10-15 and 7.5×10-10, respectively) as well as rs10007186 on 4q21.2 near ANXA3 (Pmeta = 1.3×10-9) also indicated significant associations. Interestingly, TNFRSF13B and TNFSF13 encode a tumor necrosis factor (TNF) receptor and its ligand, which together constitute an important receptor-ligand axis for B-cell homeostasis and immunoglobulin production. Furthermore, three SNPs, rs4985726, rs3803800, and rs11552708 in TNFRSF13B and TNFSF13, were indicated to be associated with serum levels of IgG (P<2.3×10-3) and IgM (P<0.018), while rs3803800 and rs11552708 were associated with IgA (P<0.013). Rs10007186 in 4q21.2 was associated with serum levels of IgA (P = 0.036), IgM (P = 0.019), and IgE (P = 4.9×10-4). Our results should add interesting knowledge about the regulation of major serum components.

Original languageEnglish
Article numbere32683
JournalPloS one
Volume7
Issue number4
DOIs
Publication statusPublished - 27-04-2012

Fingerprint

Immunoglobulin Isotypes
immunoglobulins
Serum
Immunoglobulin A
Single Nucleotide Polymorphism
Immunoglobulin M
Chromosomes
Proteins
proteins
Ligands
chromosomes
Genes
receptors
tumor necrosis factors
Tumor Necrosis Factor Receptors
Genome-Wide Association Study
serum albumin
Serum Albumin
Immunoglobulin E
B-lymphocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Osman, Wael ; Okada, Yukinori ; Kamatani, Yoichiro ; Kubo, Michiaki ; Matsuda, Koichi ; Nakamura, Yusuke. / Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. In: PloS one. 2012 ; Vol. 7, No. 4.
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Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. / Osman, Wael; Okada, Yukinori; Kamatani, Yoichiro; Kubo, Michiaki; Matsuda, Koichi; Nakamura, Yusuke.

In: PloS one, Vol. 7, No. 4, e32683, 27.04.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese

AU - Osman, Wael

AU - Okada, Yukinori

AU - Kamatani, Yoichiro

AU - Kubo, Michiaki

AU - Matsuda, Koichi

AU - Nakamura, Yusuke

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