TY - JOUR
T1 - Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia
AU - Shimokata, Keiko
AU - Yamada, Yoshiji
AU - Kondo, Takahisa
AU - Ichihara, Sahoko
AU - Izawa, Hideo
AU - Nagata, Kohzo
AU - Murohara, Toyoaki
AU - Ohno, Miyoshi
AU - Yokota, Mitsuhiro
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to M.Y.), a grant from Mitsui Life Social Welfare Foundation (to M.Y.), a Japan Heart Foundation/Pfizer Grant for Research on Hypertension, Hyperlipidemia, and Vascular Metabolism (to H.I.), and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to Y.Y.).
PY - 2004/1
Y1 - 2004/1
N2 - A substantial proportion of individuals with coronary artery disease (CAD) has concomitant hypercholesterolemia. A large-scale association study was performed to identify separately genes that confer susceptibility to CAD in the absence or presence of nonfamilial hypercholesterolemia. The study population comprised 5248 unrelated Japanese individuals, including 3085 subjects with CAD (2350 men, 735 women) and 2163 controls (1329 men, 834 women). Among all study subjects, 2541 individuals (1688 men, 853 women) had nonfamilial hypercholesterolemia, and 2707 individuals (1991 men, 716 women) did not have this condition. The genotypes for 33 polymorphisms of 27 candidate genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hyperuricemia revealed that three polymorphisms [994G → T (Val279Phe) in the platelet-activating factor acetylhydrolase gene, 242C → T (His72Tyr) in the NADH/NADPH oxidase p22 phox gene, and 1100C → T in the apolipoprotein C-III gene] were significantly associated with CAD in men with hypercholesterolemia. Genotyping of these three polymorphisms may prove informative for prediction of the genetic risk for CAD in men with nonfamilial hypercholesterolemia.
AB - A substantial proportion of individuals with coronary artery disease (CAD) has concomitant hypercholesterolemia. A large-scale association study was performed to identify separately genes that confer susceptibility to CAD in the absence or presence of nonfamilial hypercholesterolemia. The study population comprised 5248 unrelated Japanese individuals, including 3085 subjects with CAD (2350 men, 735 women) and 2163 controls (1329 men, 834 women). Among all study subjects, 2541 individuals (1688 men, 853 women) had nonfamilial hypercholesterolemia, and 2707 individuals (1991 men, 716 women) did not have this condition. The genotypes for 33 polymorphisms of 27 candidate genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hyperuricemia revealed that three polymorphisms [994G → T (Val279Phe) in the platelet-activating factor acetylhydrolase gene, 242C → T (His72Tyr) in the NADH/NADPH oxidase p22 phox gene, and 1100C → T in the apolipoprotein C-III gene] were significantly associated with CAD in men with hypercholesterolemia. Genotyping of these three polymorphisms may prove informative for prediction of the genetic risk for CAD in men with nonfamilial hypercholesterolemia.
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U2 - 10.1016/j.atherosclerosis.2003.09.019
DO - 10.1016/j.atherosclerosis.2003.09.019
M3 - Article
C2 - 14709372
AN - SCOPUS:0346094369
SN - 0021-9150
VL - 172
SP - 167
EP - 173
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -
