Association of genetic risk score and chronic kidney disease in a Japanese population

Ryosuke Fujii, Asahi Hishida, Masahiro Nakatochi, Norihiro Furusyo, Masayuki Murata, Keitaro Tanaka, Chisato Shimanoe, Sadao Suzuki, Miki Watanabe, Nagato Kuriyama, Teruhide Koyama, Toshiro Takezaki, Ippei Shimoshikiryo, Kokichi Arisawa, Sakurako Katsuura-Kamano, Naoyuki Takashima, Tanvir C. Turin, Kiyonori Kuriki, Kaori Endoh, Haruo MikamiYohko Nakamura, Isao Oze, Hidemi Ito, Michiaki Kubo, Yukihide Momozawa, Takaaki Kondo, Mariko Naito, Kenji Wakai

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Abstract

Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR <60 mL/min per 1.73 m 2 was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3%, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95% confidence interval: 1.042–1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P difference = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors.

Original languageEnglish
Pages (from-to)670-673
Number of pages4
JournalNephrology
Volume24
Issue number6
DOIs
Publication statusPublished - 06-2019

All Science Journal Classification (ASJC) codes

  • Nephrology

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    Fujii, R., Hishida, A., Nakatochi, M., Furusyo, N., Murata, M., Tanaka, K., Shimanoe, C., Suzuki, S., Watanabe, M., Kuriyama, N., Koyama, T., Takezaki, T., Shimoshikiryo, I., Arisawa, K., Katsuura-Kamano, S., Takashima, N., Turin, T. C., Kuriki, K., Endoh, K., ... Wakai, K. (2019). Association of genetic risk score and chronic kidney disease in a Japanese population. Nephrology, 24(6), 670-673. https://doi.org/10.1111/nep.13479