Association of lifelong intake of barley diet with healthy aging: Changes in physical and cognitive functions and intestinal microbiome in senescence-accelerated mouse-prone 8 (samp8)

Chikako Shimizu, Yoshihisa Wakita, Makoto Kihara, Naoyuki Kobayashi, Youichi Tsuchiya, Toshitaka Nabeshima

Research output: Contribution to journalArticle

Abstract

Barley intake reportedly reduces the risk of cardiovascular disease, but effects on the systemic phenotypes during healthy aging have not yet been examined. Therefore, we examined the effects of barley on the lifespan; behavioral phenotypes, such as locomotor activity, and cognitive functions, and intestinal microbiome in the senescence-accelerated mouse-prone 8 (SAMP8) mouse. We prepared two mild high-fat diets by adding lard, in which the starch components of AIN-93G were replaced by rice or barley “Motchiriboshi.” SAMP8 (four weeks old, male) mice were fed AIN-93G until eight weeks old, and then rice (rice group) or barley diet (rice: barley = 1:4, barley group) until death. Changes in aging-related phenotypes, object and spatial recognition, locomotor and balancing activities, and the intestinal microbiome were recorded. Moreover, plasma cholesterol levels were analyzed at 16 weeks old. Barley intake prolonged the lifespan by approximately four weeks, delayed locomotor atrophy, and reduced balancing ability and spatial recognition. Barley intake significantly increased the medium and small particle sizes of high-density lipoprotein (HDL) cholesterol, which is associated with a reduced risk of total stroke. The Bacteroidetes to Firmicutes ratio in the barley group was significantly higher than that in the rice group during aging. Thus, lifelong barley intake may have positive effects on healthy aging.

Original languageEnglish
Article number1770
JournalNutrients
Volume11
Issue number8
DOIs
Publication statusPublished - 08-2019

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Hordeum
cognition
Cognition
barley
mice
diet
rice
Locomotion
Phenotype
phenotype
microbiome
Healthy Diet
Gastrointestinal Microbiome
Bacteroidetes
Firmicutes
lard
High Fat Diet
high fat diet
atrophy
stroke

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

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title = "Association of lifelong intake of barley diet with healthy aging: Changes in physical and cognitive functions and intestinal microbiome in senescence-accelerated mouse-prone 8 (samp8)",
abstract = "Barley intake reportedly reduces the risk of cardiovascular disease, but effects on the systemic phenotypes during healthy aging have not yet been examined. Therefore, we examined the effects of barley on the lifespan; behavioral phenotypes, such as locomotor activity, and cognitive functions, and intestinal microbiome in the senescence-accelerated mouse-prone 8 (SAMP8) mouse. We prepared two mild high-fat diets by adding lard, in which the starch components of AIN-93G were replaced by rice or barley “Motchiriboshi.” SAMP8 (four weeks old, male) mice were fed AIN-93G until eight weeks old, and then rice (rice group) or barley diet (rice: barley = 1:4, barley group) until death. Changes in aging-related phenotypes, object and spatial recognition, locomotor and balancing activities, and the intestinal microbiome were recorded. Moreover, plasma cholesterol levels were analyzed at 16 weeks old. Barley intake prolonged the lifespan by approximately four weeks, delayed locomotor atrophy, and reduced balancing ability and spatial recognition. Barley intake significantly increased the medium and small particle sizes of high-density lipoprotein (HDL) cholesterol, which is associated with a reduced risk of total stroke. The Bacteroidetes to Firmicutes ratio in the barley group was significantly higher than that in the rice group during aging. Thus, lifelong barley intake may have positive effects on healthy aging.",
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Association of lifelong intake of barley diet with healthy aging : Changes in physical and cognitive functions and intestinal microbiome in senescence-accelerated mouse-prone 8 (samp8). / Shimizu, Chikako; Wakita, Yoshihisa; Kihara, Makoto; Kobayashi, Naoyuki; Tsuchiya, Youichi; Nabeshima, Toshitaka.

In: Nutrients, Vol. 11, No. 8, 1770, 08.2019.

Research output: Contribution to journalArticle

TY - JOUR

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T2 - Changes in physical and cognitive functions and intestinal microbiome in senescence-accelerated mouse-prone 8 (samp8)

AU - Shimizu, Chikako

AU - Wakita, Yoshihisa

AU - Kihara, Makoto

AU - Kobayashi, Naoyuki

AU - Tsuchiya, Youichi

AU - Nabeshima, Toshitaka

PY - 2019/8

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