Abstract
Barley intake reportedly reduces the risk of cardiovascular disease, but effects on the systemic phenotypes during healthy aging have not yet been examined. Therefore, we examined the effects of barley on the lifespan; behavioral phenotypes, such as locomotor activity, and cognitive functions, and intestinal microbiome in the senescence-accelerated mouse-prone 8 (SAMP8) mouse. We prepared two mild high-fat diets by adding lard, in which the starch components of AIN-93G were replaced by rice or barley “Motchiriboshi.” SAMP8 (four weeks old, male) mice were fed AIN-93G until eight weeks old, and then rice (rice group) or barley diet (rice: barley = 1:4, barley group) until death. Changes in aging-related phenotypes, object and spatial recognition, locomotor and balancing activities, and the intestinal microbiome were recorded. Moreover, plasma cholesterol levels were analyzed at 16 weeks old. Barley intake prolonged the lifespan by approximately four weeks, delayed locomotor atrophy, and reduced balancing ability and spatial recognition. Barley intake significantly increased the medium and small particle sizes of high-density lipoprotein (HDL) cholesterol, which is associated with a reduced risk of total stroke. The Bacteroidetes to Firmicutes ratio in the barley group was significantly higher than that in the rice group during aging. Thus, lifelong barley intake may have positive effects on healthy aging.
| Original language | English |
|---|---|
| Article number | 1770 |
| Journal | Nutrients |
| Volume | 11 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 08-2019 |
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All Science Journal Classification (ASJC) codes
- Food Science
- Nutrition and Dietetics
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Association of lifelong intake of barley diet with healthy aging : Changes in physical and cognitive functions and intestinal microbiome in senescence-accelerated mouse-prone 8 (samp8). / Shimizu, Chikako; Wakita, Yoshihisa; Kihara, Makoto; Kobayashi, Naoyuki; Tsuchiya, Youichi; Nabeshima, Toshitaka.
In: Nutrients, Vol. 11, No. 8, 1770, 08.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association of lifelong intake of barley diet with healthy aging
T2 - Changes in physical and cognitive functions and intestinal microbiome in senescence-accelerated mouse-prone 8 (samp8)
AU - Shimizu, Chikako
AU - Wakita, Yoshihisa
AU - Kihara, Makoto
AU - Kobayashi, Naoyuki
AU - Tsuchiya, Youichi
AU - Nabeshima, Toshitaka
PY - 2019/8
Y1 - 2019/8
N2 - Barley intake reportedly reduces the risk of cardiovascular disease, but effects on the systemic phenotypes during healthy aging have not yet been examined. Therefore, we examined the effects of barley on the lifespan; behavioral phenotypes, such as locomotor activity, and cognitive functions, and intestinal microbiome in the senescence-accelerated mouse-prone 8 (SAMP8) mouse. We prepared two mild high-fat diets by adding lard, in which the starch components of AIN-93G were replaced by rice or barley “Motchiriboshi.” SAMP8 (four weeks old, male) mice were fed AIN-93G until eight weeks old, and then rice (rice group) or barley diet (rice: barley = 1:4, barley group) until death. Changes in aging-related phenotypes, object and spatial recognition, locomotor and balancing activities, and the intestinal microbiome were recorded. Moreover, plasma cholesterol levels were analyzed at 16 weeks old. Barley intake prolonged the lifespan by approximately four weeks, delayed locomotor atrophy, and reduced balancing ability and spatial recognition. Barley intake significantly increased the medium and small particle sizes of high-density lipoprotein (HDL) cholesterol, which is associated with a reduced risk of total stroke. The Bacteroidetes to Firmicutes ratio in the barley group was significantly higher than that in the rice group during aging. Thus, lifelong barley intake may have positive effects on healthy aging.
AB - Barley intake reportedly reduces the risk of cardiovascular disease, but effects on the systemic phenotypes during healthy aging have not yet been examined. Therefore, we examined the effects of barley on the lifespan; behavioral phenotypes, such as locomotor activity, and cognitive functions, and intestinal microbiome in the senescence-accelerated mouse-prone 8 (SAMP8) mouse. We prepared two mild high-fat diets by adding lard, in which the starch components of AIN-93G were replaced by rice or barley “Motchiriboshi.” SAMP8 (four weeks old, male) mice were fed AIN-93G until eight weeks old, and then rice (rice group) or barley diet (rice: barley = 1:4, barley group) until death. Changes in aging-related phenotypes, object and spatial recognition, locomotor and balancing activities, and the intestinal microbiome were recorded. Moreover, plasma cholesterol levels were analyzed at 16 weeks old. Barley intake prolonged the lifespan by approximately four weeks, delayed locomotor atrophy, and reduced balancing ability and spatial recognition. Barley intake significantly increased the medium and small particle sizes of high-density lipoprotein (HDL) cholesterol, which is associated with a reduced risk of total stroke. The Bacteroidetes to Firmicutes ratio in the barley group was significantly higher than that in the rice group during aging. Thus, lifelong barley intake may have positive effects on healthy aging.
UR - http://www.scopus.com/inward/record.url?scp=85071169692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071169692&partnerID=8YFLogxK
U2 - 10.3390/nu11081770
DO - 10.3390/nu11081770
M3 - Article
C2 - 31374892
AN - SCOPUS:85071169692
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 8
M1 - 1770
ER -