Association of mast cells with Warthin's tumor in fine needle aspirates of the salivary gland

Tadao K. Kobayashi, Masami Ueda, Toshihiro Nishino, Ryoji Kushima, Shigemi Nakajima, Chiyuki Kaneko

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


OBJECTIVE: To determine the significance of the presence of mast cells in Warthin's tumor by evaluating the occurrence of these cells in cellular and immunohistochemical preparations. STUDY DESIGN: Specimens derived from five cases of FNAC were examined. A total of four slides from five cases were prepared from each: two air-dried smears were stained with May-Grunwald- Giemsa (MGG) stain and two with Hansel's stain. The other two were alcohol fixed and stained using the Papanicolaou method. The smears were evaluated for the presence of mast cells, especially associated with oxyphilic cells. In order to investigate the location of mast cells, we also counted those cells by means of immunohistochemistry using anti-mast cell monoclonal antibody AA1. RESULTS: The Hansel-stained cellular sample from Warthin's tumor contained numerous mast cells, associated mainly with large, oxyphilic cell sheers. The number of AA1-positive cells (mast cells) stained with immunohistochemistry was greater in epithelial component than in lymphoid stroma. CONCLUSION: Mast cells in a salivary gland aspirate might be indicative of Warthin's tumor; therefore, MGG-stained slides offer the advantage of ease of preparation, particularly when the typical cytologic features are not present.

Original languageEnglish
Pages (from-to)1052-1058
Number of pages7
JournalActa Cytologica
Issue number6
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology


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