Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: A cross-sectional study

Xiaofang Jia, Masahiro Tagawa, Hiroshi Yatsuya, Hisao Naito, Yumi Hayashi, Husna Yetti, Seiko Sasaki, Atsuko Araki, Chihiro Miyashita, Tamiko Ikeno, Reiko Kishi, Tamie Nakajima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions. Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with birth weight, length, and chest or head circumferences by multivariate regression models, using data from 318 mother-newborn pairs of the Hokkaido Study. Results: The absolute and/or relative contents of maternal blood docosahexaenoic acid and arachidonic acid were lowest at 35-41 gestational weeks during pregnancy, as was the essential FA status index. Different from palmitic and stearic acids, palmitoleic and oleic acid contents were higher at 35-41 gestational weeks than those at 23-31 gestational weeks. Three FA components were identified through principal component analysis, and were used in association analysis. Component 3, which was positively and significantly loaded by eicosapentaenoic acid (EPA), was associated with chest circumference [β=0.281, 95% confidence interval (CI): 0.006, 0.556] at 35-41 gestational weeks (P=0.046). No significant associations were observed for Component 1 and 2 loaded by FAs except EPA. Conclusion: Maternal blood EPA content may have an important influence on infant chest circumference.

Original languageEnglish
Pages (from-to)565-575
Number of pages11
JournalJournal of Perinatal Medicine
Volume43
Issue number5
DOIs
Publication statusPublished - 01-09-2015

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Term Birth
Fatty Acids
Cross-Sectional Studies
Mothers
Eicosapentaenoic Acid
Thorax
Pregnancy
Stearic Acids
Essential Fatty Acids
Docosahexaenoic Acids
Third Pregnancy Trimester
Second Pregnancy Trimester
Principal Component Analysis
Arachidonic Acid
Birth Weight
Head
Newborn Infant
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Jia, Xiaofang ; Tagawa, Masahiro ; Yatsuya, Hiroshi ; Naito, Hisao ; Hayashi, Yumi ; Yetti, Husna ; Sasaki, Seiko ; Araki, Atsuko ; Miyashita, Chihiro ; Ikeno, Tamiko ; Kishi, Reiko ; Nakajima, Tamie. / Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions : A cross-sectional study. In: Journal of Perinatal Medicine. 2015 ; Vol. 43, No. 5. pp. 565-575.
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abstract = "To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions. Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with birth weight, length, and chest or head circumferences by multivariate regression models, using data from 318 mother-newborn pairs of the Hokkaido Study. Results: The absolute and/or relative contents of maternal blood docosahexaenoic acid and arachidonic acid were lowest at 35-41 gestational weeks during pregnancy, as was the essential FA status index. Different from palmitic and stearic acids, palmitoleic and oleic acid contents were higher at 35-41 gestational weeks than those at 23-31 gestational weeks. Three FA components were identified through principal component analysis, and were used in association analysis. Component 3, which was positively and significantly loaded by eicosapentaenoic acid (EPA), was associated with chest circumference [β=0.281, 95{\%} confidence interval (CI): 0.006, 0.556] at 35-41 gestational weeks (P=0.046). No significant associations were observed for Component 1 and 2 loaded by FAs except EPA. Conclusion: Maternal blood EPA content may have an important influence on infant chest circumference.",
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Jia, X, Tagawa, M, Yatsuya, H, Naito, H, Hayashi, Y, Yetti, H, Sasaki, S, Araki, A, Miyashita, C, Ikeno, T, Kishi, R & Nakajima, T 2015, 'Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: A cross-sectional study', Journal of Perinatal Medicine, vol. 43, no. 5, pp. 565-575. https://doi.org/10.1515/jpm-2014-0277

Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions : A cross-sectional study. / Jia, Xiaofang; Tagawa, Masahiro; Yatsuya, Hiroshi; Naito, Hisao; Hayashi, Yumi; Yetti, Husna; Sasaki, Seiko; Araki, Atsuko; Miyashita, Chihiro; Ikeno, Tamiko; Kishi, Reiko; Nakajima, Tamie.

In: Journal of Perinatal Medicine, Vol. 43, No. 5, 01.09.2015, p. 565-575.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions

T2 - A cross-sectional study

AU - Jia, Xiaofang

AU - Tagawa, Masahiro

AU - Yatsuya, Hiroshi

AU - Naito, Hisao

AU - Hayashi, Yumi

AU - Yetti, Husna

AU - Sasaki, Seiko

AU - Araki, Atsuko

AU - Miyashita, Chihiro

AU - Ikeno, Tamiko

AU - Kishi, Reiko

AU - Nakajima, Tamie

PY - 2015/9/1

Y1 - 2015/9/1

N2 - To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions. Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with birth weight, length, and chest or head circumferences by multivariate regression models, using data from 318 mother-newborn pairs of the Hokkaido Study. Results: The absolute and/or relative contents of maternal blood docosahexaenoic acid and arachidonic acid were lowest at 35-41 gestational weeks during pregnancy, as was the essential FA status index. Different from palmitic and stearic acids, palmitoleic and oleic acid contents were higher at 35-41 gestational weeks than those at 23-31 gestational weeks. Three FA components were identified through principal component analysis, and were used in association analysis. Component 3, which was positively and significantly loaded by eicosapentaenoic acid (EPA), was associated with chest circumference [β=0.281, 95% confidence interval (CI): 0.006, 0.556] at 35-41 gestational weeks (P=0.046). No significant associations were observed for Component 1 and 2 loaded by FAs except EPA. Conclusion: Maternal blood EPA content may have an important influence on infant chest circumference.

AB - To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions. Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with birth weight, length, and chest or head circumferences by multivariate regression models, using data from 318 mother-newborn pairs of the Hokkaido Study. Results: The absolute and/or relative contents of maternal blood docosahexaenoic acid and arachidonic acid were lowest at 35-41 gestational weeks during pregnancy, as was the essential FA status index. Different from palmitic and stearic acids, palmitoleic and oleic acid contents were higher at 35-41 gestational weeks than those at 23-31 gestational weeks. Three FA components were identified through principal component analysis, and were used in association analysis. Component 3, which was positively and significantly loaded by eicosapentaenoic acid (EPA), was associated with chest circumference [β=0.281, 95% confidence interval (CI): 0.006, 0.556] at 35-41 gestational weeks (P=0.046). No significant associations were observed for Component 1 and 2 loaded by FAs except EPA. Conclusion: Maternal blood EPA content may have an important influence on infant chest circumference.

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