Association of serum carotenoid levels with N-terminal pro-brain-type natriuretic peptide

A cross-sectional study in Japan

Koji Suzuki, Junichi Ishii, Fumihiko Kitagawa, Atsuhiro Kuno, Yasuhiro Kusuhara, Junichi Ochiai, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroya Yamada, Yoshinori Ito, Nobuyuki Hamajima, Takashi Inoue

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population. Methods: In this cross-sectional study,we investigated whether serum carotenoids were associated with serum NTproBNP in 1056 Japanese subjects (390 men, 666 women) who attended a health examination. Serum levels of carotenoids were separately determined by high-performance liquid chromatography. Serum NT-proBNP level was measured by electrochemiluminescence immunoassay. Results: Serum NT-proBNP was elevated (≥55 pg/ml) in 31.8% of men and 48.2% of women. Multivariate logistic regression analyses adjusted for confounding factors showed a significant association between the highest quartile of serum a-carotene and elevated NT-proBNP in men (odds ratio [OR]= 0.40, 95% CI = 0.19-0.82, P for trend = 0.005) and women (OR = 0.62, 95% CI = 0.39-0.99, P for trend = 0.047). In women, moreover, elevated serum NTproBNP was significantly associated with serum canthaxanthin (OR = 0.57, 95% CI = 0.36-0.90 for highest quartile, P for trend = 0.026) and ß-cryptoxanthin (OR = 0.53, 95% CI = 0.32-0.85 for highest quartile, P for trend = 0.026), after adjusting for potential confounders. Conclusions: Higher levels of serum carotenoids were associated with lower risk of elevated serum NT-proBNP levels after adjusting for possible confounders, which suggests that a diet rich in carotenoids could help prevent cardiac overload in the Japanese population.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalJournal of epidemiology
Volume23
Issue number3
DOIs
Publication statusPublished - 18-07-2013

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Brain Natriuretic Peptide
Carotenoids
Japan
Cross-Sectional Studies
Serum
Odds Ratio
peptide A
Canthaxanthin
Immunoassay
Population
Epidemiologic Studies
Cardiovascular Diseases
Logistic Models
High Pressure Liquid Chromatography
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Suzuki, Koji ; Ishii, Junichi ; Kitagawa, Fumihiko ; Kuno, Atsuhiro ; Kusuhara, Yasuhiro ; Ochiai, Junichi ; Ichino, Naohiro ; Osakabe, Keisuke ; Sugimoto, Keiko ; Yamada, Hiroya ; Ito, Yoshinori ; Hamajima, Nobuyuki ; Inoue, Takashi. / Association of serum carotenoid levels with N-terminal pro-brain-type natriuretic peptide : A cross-sectional study in Japan. In: Journal of epidemiology. 2013 ; Vol. 23, No. 3. pp. 163-168.
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title = "Association of serum carotenoid levels with N-terminal pro-brain-type natriuretic peptide: A cross-sectional study in Japan",
abstract = "Background: Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population. Methods: In this cross-sectional study,we investigated whether serum carotenoids were associated with serum NTproBNP in 1056 Japanese subjects (390 men, 666 women) who attended a health examination. Serum levels of carotenoids were separately determined by high-performance liquid chromatography. Serum NT-proBNP level was measured by electrochemiluminescence immunoassay. Results: Serum NT-proBNP was elevated (≥55 pg/ml) in 31.8{\%} of men and 48.2{\%} of women. Multivariate logistic regression analyses adjusted for confounding factors showed a significant association between the highest quartile of serum a-carotene and elevated NT-proBNP in men (odds ratio [OR]= 0.40, 95{\%} CI = 0.19-0.82, P for trend = 0.005) and women (OR = 0.62, 95{\%} CI = 0.39-0.99, P for trend = 0.047). In women, moreover, elevated serum NTproBNP was significantly associated with serum canthaxanthin (OR = 0.57, 95{\%} CI = 0.36-0.90 for highest quartile, P for trend = 0.026) and {\ss}-cryptoxanthin (OR = 0.53, 95{\%} CI = 0.32-0.85 for highest quartile, P for trend = 0.026), after adjusting for potential confounders. Conclusions: Higher levels of serum carotenoids were associated with lower risk of elevated serum NT-proBNP levels after adjusting for possible confounders, which suggests that a diet rich in carotenoids could help prevent cardiac overload in the Japanese population.",
author = "Koji Suzuki and Junichi Ishii and Fumihiko Kitagawa and Atsuhiro Kuno and Yasuhiro Kusuhara and Junichi Ochiai and Naohiro Ichino and Keisuke Osakabe and Keiko Sugimoto and Hiroya Yamada and Yoshinori Ito and Nobuyuki Hamajima and Takashi Inoue",
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Association of serum carotenoid levels with N-terminal pro-brain-type natriuretic peptide : A cross-sectional study in Japan. / Suzuki, Koji; Ishii, Junichi; Kitagawa, Fumihiko; Kuno, Atsuhiro; Kusuhara, Yasuhiro; Ochiai, Junichi; Ichino, Naohiro; Osakabe, Keisuke; Sugimoto, Keiko; Yamada, Hiroya; Ito, Yoshinori; Hamajima, Nobuyuki; Inoue, Takashi.

In: Journal of epidemiology, Vol. 23, No. 3, 18.07.2013, p. 163-168.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of serum carotenoid levels with N-terminal pro-brain-type natriuretic peptide

T2 - A cross-sectional study in Japan

AU - Suzuki, Koji

AU - Ishii, Junichi

AU - Kitagawa, Fumihiko

AU - Kuno, Atsuhiro

AU - Kusuhara, Yasuhiro

AU - Ochiai, Junichi

AU - Ichino, Naohiro

AU - Osakabe, Keisuke

AU - Sugimoto, Keiko

AU - Yamada, Hiroya

AU - Ito, Yoshinori

AU - Hamajima, Nobuyuki

AU - Inoue, Takashi

PY - 2013/7/18

Y1 - 2013/7/18

N2 - Background: Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population. Methods: In this cross-sectional study,we investigated whether serum carotenoids were associated with serum NTproBNP in 1056 Japanese subjects (390 men, 666 women) who attended a health examination. Serum levels of carotenoids were separately determined by high-performance liquid chromatography. Serum NT-proBNP level was measured by electrochemiluminescence immunoassay. Results: Serum NT-proBNP was elevated (≥55 pg/ml) in 31.8% of men and 48.2% of women. Multivariate logistic regression analyses adjusted for confounding factors showed a significant association between the highest quartile of serum a-carotene and elevated NT-proBNP in men (odds ratio [OR]= 0.40, 95% CI = 0.19-0.82, P for trend = 0.005) and women (OR = 0.62, 95% CI = 0.39-0.99, P for trend = 0.047). In women, moreover, elevated serum NTproBNP was significantly associated with serum canthaxanthin (OR = 0.57, 95% CI = 0.36-0.90 for highest quartile, P for trend = 0.026) and ß-cryptoxanthin (OR = 0.53, 95% CI = 0.32-0.85 for highest quartile, P for trend = 0.026), after adjusting for potential confounders. Conclusions: Higher levels of serum carotenoids were associated with lower risk of elevated serum NT-proBNP levels after adjusting for possible confounders, which suggests that a diet rich in carotenoids could help prevent cardiac overload in the Japanese population.

AB - Background: Several epidemiologic studies have reported an inverse association between serum levels of carotenoids and cardiovascular disease risk. However, no studies have reported an association between serum carotenoids and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in the general population. Methods: In this cross-sectional study,we investigated whether serum carotenoids were associated with serum NTproBNP in 1056 Japanese subjects (390 men, 666 women) who attended a health examination. Serum levels of carotenoids were separately determined by high-performance liquid chromatography. Serum NT-proBNP level was measured by electrochemiluminescence immunoassay. Results: Serum NT-proBNP was elevated (≥55 pg/ml) in 31.8% of men and 48.2% of women. Multivariate logistic regression analyses adjusted for confounding factors showed a significant association between the highest quartile of serum a-carotene and elevated NT-proBNP in men (odds ratio [OR]= 0.40, 95% CI = 0.19-0.82, P for trend = 0.005) and women (OR = 0.62, 95% CI = 0.39-0.99, P for trend = 0.047). In women, moreover, elevated serum NTproBNP was significantly associated with serum canthaxanthin (OR = 0.57, 95% CI = 0.36-0.90 for highest quartile, P for trend = 0.026) and ß-cryptoxanthin (OR = 0.53, 95% CI = 0.32-0.85 for highest quartile, P for trend = 0.026), after adjusting for potential confounders. Conclusions: Higher levels of serum carotenoids were associated with lower risk of elevated serum NT-proBNP levels after adjusting for possible confounders, which suggests that a diet rich in carotenoids could help prevent cardiac overload in the Japanese population.

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U2 - 10.2188/jea.JE20120087

DO - 10.2188/jea.JE20120087

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