Association of serum carotenoid levels with urinary albumin excretion in a general Japanese population

The Yakumo study

Koji Suzuki, Hisashi Honjo, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Hiroya Yamada, Yasuhiro Kusuhara, Rika Watarai, Takeshi Hamajima, Nobuyuki Hamajima, Takashi Inoue

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Albuminuria is a risk factor for not only nephropathy progression but also cardiovascular disease. Oxidative stress may have a role in the positive association between albuminuria and cardiovascular disease. Methods: This cross-sectional study investigated the associations of serum levels of carotenoids, which are dietary antioxidants, with albuminuria among 501 Japanese adults (198 men, mean age ± SD: 66.4 ± 10.0 years; 303 women, mean age ± SD: 65.4 ± 9.8 years) who attended a health examination. Serum levels of carotenoids were determined by high-performance liquid chromatography. Logistic regression analysis was used to estimate odds ratios (ORs) with 95% CIs for albuminuria after adjustment for age, body mass index, smoking habits, drinking habits, hypertension, diabetes mellitus, and dyslipidemia. Results: Prevalence of albuminuria was 15.4% among men and 18.1% among women. Among women with albuminuria, geometric mean serum levels of canthaxanthin, lycopene, ß-carotene, total carotenes, and provitamin A were significantly lower than those of normoalbuminuric women. Adjusted ORs for albuminuria among women in the highest tertiles of serum ß-carotene (OR, 0.45; 95% CI, 0.20-0.98) and provitamin A (OR, 0.45; 95% CI, 0.20-0.97) were significantly lower as compared with those for women in the lowest tertile. There were no associations between serum carotenoids and albuminuria in men. Conclusions: An increased level of serum provitamin A, especially serum ß-carotene, was independently associated with lower risk of albuminuria among Japanese women.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalJournal of epidemiology
Volume23
Issue number6
DOIs
Publication statusPublished - 31-08-2013

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Albuminuria
Carotenoids
Albumins
Serum
Population
Odds Ratio
Habits
Cardiovascular Diseases
Canthaxanthin
Dyslipidemias
Drinking
Diabetes Mellitus
Oxidative Stress
Body Mass Index
Cross-Sectional Studies
Antioxidants
Logistic Models
Smoking
High Pressure Liquid Chromatography
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Suzuki, Koji ; Honjo, Hisashi ; Ichino, Naohiro ; Osakabe, Keisuke ; Sugimoto, Keiko ; Yamada, Hiroya ; Kusuhara, Yasuhiro ; Watarai, Rika ; Hamajima, Takeshi ; Hamajima, Nobuyuki ; Inoue, Takashi. / Association of serum carotenoid levels with urinary albumin excretion in a general Japanese population : The Yakumo study. In: Journal of epidemiology. 2013 ; Vol. 23, No. 6. pp. 451-456.
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abstract = "Background: Albuminuria is a risk factor for not only nephropathy progression but also cardiovascular disease. Oxidative stress may have a role in the positive association between albuminuria and cardiovascular disease. Methods: This cross-sectional study investigated the associations of serum levels of carotenoids, which are dietary antioxidants, with albuminuria among 501 Japanese adults (198 men, mean age ± SD: 66.4 ± 10.0 years; 303 women, mean age ± SD: 65.4 ± 9.8 years) who attended a health examination. Serum levels of carotenoids were determined by high-performance liquid chromatography. Logistic regression analysis was used to estimate odds ratios (ORs) with 95{\%} CIs for albuminuria after adjustment for age, body mass index, smoking habits, drinking habits, hypertension, diabetes mellitus, and dyslipidemia. Results: Prevalence of albuminuria was 15.4{\%} among men and 18.1{\%} among women. Among women with albuminuria, geometric mean serum levels of canthaxanthin, lycopene, {\ss}-carotene, total carotenes, and provitamin A were significantly lower than those of normoalbuminuric women. Adjusted ORs for albuminuria among women in the highest tertiles of serum {\ss}-carotene (OR, 0.45; 95{\%} CI, 0.20-0.98) and provitamin A (OR, 0.45; 95{\%} CI, 0.20-0.97) were significantly lower as compared with those for women in the lowest tertile. There were no associations between serum carotenoids and albuminuria in men. Conclusions: An increased level of serum provitamin A, especially serum {\ss}-carotene, was independently associated with lower risk of albuminuria among Japanese women.",
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Association of serum carotenoid levels with urinary albumin excretion in a general Japanese population : The Yakumo study. / Suzuki, Koji; Honjo, Hisashi; Ichino, Naohiro; Osakabe, Keisuke; Sugimoto, Keiko; Yamada, Hiroya; Kusuhara, Yasuhiro; Watarai, Rika; Hamajima, Takeshi; Hamajima, Nobuyuki; Inoue, Takashi.

In: Journal of epidemiology, Vol. 23, No. 6, 31.08.2013, p. 451-456.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of serum carotenoid levels with urinary albumin excretion in a general Japanese population

T2 - The Yakumo study

AU - Suzuki, Koji

AU - Honjo, Hisashi

AU - Ichino, Naohiro

AU - Osakabe, Keisuke

AU - Sugimoto, Keiko

AU - Yamada, Hiroya

AU - Kusuhara, Yasuhiro

AU - Watarai, Rika

AU - Hamajima, Takeshi

AU - Hamajima, Nobuyuki

AU - Inoue, Takashi

PY - 2013/8/31

Y1 - 2013/8/31

N2 - Background: Albuminuria is a risk factor for not only nephropathy progression but also cardiovascular disease. Oxidative stress may have a role in the positive association between albuminuria and cardiovascular disease. Methods: This cross-sectional study investigated the associations of serum levels of carotenoids, which are dietary antioxidants, with albuminuria among 501 Japanese adults (198 men, mean age ± SD: 66.4 ± 10.0 years; 303 women, mean age ± SD: 65.4 ± 9.8 years) who attended a health examination. Serum levels of carotenoids were determined by high-performance liquid chromatography. Logistic regression analysis was used to estimate odds ratios (ORs) with 95% CIs for albuminuria after adjustment for age, body mass index, smoking habits, drinking habits, hypertension, diabetes mellitus, and dyslipidemia. Results: Prevalence of albuminuria was 15.4% among men and 18.1% among women. Among women with albuminuria, geometric mean serum levels of canthaxanthin, lycopene, ß-carotene, total carotenes, and provitamin A were significantly lower than those of normoalbuminuric women. Adjusted ORs for albuminuria among women in the highest tertiles of serum ß-carotene (OR, 0.45; 95% CI, 0.20-0.98) and provitamin A (OR, 0.45; 95% CI, 0.20-0.97) were significantly lower as compared with those for women in the lowest tertile. There were no associations between serum carotenoids and albuminuria in men. Conclusions: An increased level of serum provitamin A, especially serum ß-carotene, was independently associated with lower risk of albuminuria among Japanese women.

AB - Background: Albuminuria is a risk factor for not only nephropathy progression but also cardiovascular disease. Oxidative stress may have a role in the positive association between albuminuria and cardiovascular disease. Methods: This cross-sectional study investigated the associations of serum levels of carotenoids, which are dietary antioxidants, with albuminuria among 501 Japanese adults (198 men, mean age ± SD: 66.4 ± 10.0 years; 303 women, mean age ± SD: 65.4 ± 9.8 years) who attended a health examination. Serum levels of carotenoids were determined by high-performance liquid chromatography. Logistic regression analysis was used to estimate odds ratios (ORs) with 95% CIs for albuminuria after adjustment for age, body mass index, smoking habits, drinking habits, hypertension, diabetes mellitus, and dyslipidemia. Results: Prevalence of albuminuria was 15.4% among men and 18.1% among women. Among women with albuminuria, geometric mean serum levels of canthaxanthin, lycopene, ß-carotene, total carotenes, and provitamin A were significantly lower than those of normoalbuminuric women. Adjusted ORs for albuminuria among women in the highest tertiles of serum ß-carotene (OR, 0.45; 95% CI, 0.20-0.98) and provitamin A (OR, 0.45; 95% CI, 0.20-0.97) were significantly lower as compared with those for women in the lowest tertile. There were no associations between serum carotenoids and albuminuria in men. Conclusions: An increased level of serum provitamin A, especially serum ß-carotene, was independently associated with lower risk of albuminuria among Japanese women.

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