Association of serum carotenoids with high molecular weight adiponectin and inflammation markers among Japanese subjects

Koji Suzuki, Takashi Inoue, Shuji Hashimoto, Junichi Ochiai, Yasuhiro Kusuhara, Yoshinori Ito, Nobuyuki Hamajima

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Several studies have reported that serum concentrations of carotenoids and adiponectin are inversely associated with the risk for cardiovascular disease (CVD). However, no studies have investigated the association between serum concentrations of adiponectin and carotenoids in the general population. Methods: We investigated cross-sectionally whether serum carotenoids are associated with serum high molecular weight (HMW) adiponectin and some inflammatory markers in 437 Japanese subjects (116 men and 321 women) who attended a health examination. Results: In multiple linear regression analysis adjusted for confounding factors, serum β-carotene concentrations were significantly associated with serum HMW adiponectin concentrations in both sexes (standardized β coefficient = 0.197, p= 0.036 for men; standardized β coefficient = 0.146, p=0.012 for women). Serum α-carotene and β-carotene concentrations were significantly associated with serum C-reactive protein (CRP) concentrations in men. In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Additional adjustment for serum concentrations of IL-6 or CRP did not significantly affect the association between carotenoids and HMW adiponectin in non-smoking men as well as in women. Conclusion: Serum β-carotene concentrations were positively associated with serum HMW adiponectin concentrations even after adjustment for possible confounding factors including inflammatory markers.

Original languageEnglish
Pages (from-to)1330-1334
Number of pages5
JournalClinica Chimica Acta
Volume411
Issue number17-18
DOIs
Publication statusPublished - 01-09-2010

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Adiponectin
Carotenoids
Molecular Weight
Molecular weight
Inflammation
Serum
C-Reactive Protein
Interleukin-6
Linear regression
Regression analysis
Health
Blood Proteins
Linear Models
Cardiovascular Diseases
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Suzuki, Koji ; Inoue, Takashi ; Hashimoto, Shuji ; Ochiai, Junichi ; Kusuhara, Yasuhiro ; Ito, Yoshinori ; Hamajima, Nobuyuki. / Association of serum carotenoids with high molecular weight adiponectin and inflammation markers among Japanese subjects. In: Clinica Chimica Acta. 2010 ; Vol. 411, No. 17-18. pp. 1330-1334.
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Association of serum carotenoids with high molecular weight adiponectin and inflammation markers among Japanese subjects. / Suzuki, Koji; Inoue, Takashi; Hashimoto, Shuji; Ochiai, Junichi; Kusuhara, Yasuhiro; Ito, Yoshinori; Hamajima, Nobuyuki.

In: Clinica Chimica Acta, Vol. 411, No. 17-18, 01.09.2010, p. 1330-1334.

Research output: Contribution to journalArticle

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AU - Inoue, Takashi

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AU - Hamajima, Nobuyuki

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