TY - JOUR
T1 - Association of serum carotenoids with high molecular weight adiponectin and inflammation markers among Japanese subjects
AU - Suzuki, Koji
AU - Inoue, Takashi
AU - Hashimoto, Shuji
AU - Ochiai, Junichi
AU - Kusuhara, Yasuhiro
AU - Ito, Yoshinori
AU - Hamajima, Nobuyuki
N1 - Funding Information:
This study was supported in part by a grant from Fujita Health University . We thank the participants and staff of the health examination program for residents of Yakumo Town, Hokkaido, Japan.
PY - 2010/9
Y1 - 2010/9
N2 - Background: Several studies have reported that serum concentrations of carotenoids and adiponectin are inversely associated with the risk for cardiovascular disease (CVD). However, no studies have investigated the association between serum concentrations of adiponectin and carotenoids in the general population. Methods: We investigated cross-sectionally whether serum carotenoids are associated with serum high molecular weight (HMW) adiponectin and some inflammatory markers in 437 Japanese subjects (116 men and 321 women) who attended a health examination. Results: In multiple linear regression analysis adjusted for confounding factors, serum β-carotene concentrations were significantly associated with serum HMW adiponectin concentrations in both sexes (standardized β coefficient = 0.197, p= 0.036 for men; standardized β coefficient = 0.146, p=0.012 for women). Serum α-carotene and β-carotene concentrations were significantly associated with serum C-reactive protein (CRP) concentrations in men. In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Additional adjustment for serum concentrations of IL-6 or CRP did not significantly affect the association between carotenoids and HMW adiponectin in non-smoking men as well as in women. Conclusion: Serum β-carotene concentrations were positively associated with serum HMW adiponectin concentrations even after adjustment for possible confounding factors including inflammatory markers.
AB - Background: Several studies have reported that serum concentrations of carotenoids and adiponectin are inversely associated with the risk for cardiovascular disease (CVD). However, no studies have investigated the association between serum concentrations of adiponectin and carotenoids in the general population. Methods: We investigated cross-sectionally whether serum carotenoids are associated with serum high molecular weight (HMW) adiponectin and some inflammatory markers in 437 Japanese subjects (116 men and 321 women) who attended a health examination. Results: In multiple linear regression analysis adjusted for confounding factors, serum β-carotene concentrations were significantly associated with serum HMW adiponectin concentrations in both sexes (standardized β coefficient = 0.197, p= 0.036 for men; standardized β coefficient = 0.146, p=0.012 for women). Serum α-carotene and β-carotene concentrations were significantly associated with serum C-reactive protein (CRP) concentrations in men. In women, there were significant negative associations between serum carotenoids concentrations and serum interleukin-6 (IL-6) concentrations. Additional adjustment for serum concentrations of IL-6 or CRP did not significantly affect the association between carotenoids and HMW adiponectin in non-smoking men as well as in women. Conclusion: Serum β-carotene concentrations were positively associated with serum HMW adiponectin concentrations even after adjustment for possible confounding factors including inflammatory markers.
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U2 - 10.1016/j.cca.2010.05.029
DO - 10.1016/j.cca.2010.05.029
M3 - Article
C2 - 20580698
AN - SCOPUS:77954141829
SN - 0009-8981
VL - 411
SP - 1330
EP - 1334
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 17-18
ER -
