Association of serum NO x level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan

Jun Ueyama, Takaaki Kondo, Ryota Imai, Akiko Kimata, Kanami Yamamoto, Koji Suzuki, Takashi Inoue, Yoshinori Ito, Ken Ichi Miyamoto, Takaaki Hasegawa, Nobuyuki Hamajima

Research output: Contribution to journalArticle

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Abstract

Objectives: The aim of this study was to determine whether the serum nitrite plus nitrate (NO x ) level correlates with biomarkers that are known components of the metabolic syndrome (MetS). Methods: Serum NO x levels were measured using a commercial kit in 608 Japanese men and women between the ages of 39 and 85 years. Multivariate adjustments for age, smoking status, alcohol consumption and exercise were made in the analysis of covariance (ANCOVA). The components of the metabolic syndrome were defined based on the following criteria: body mass index (BMI) ≥25.0 kg/m 2 , glycated hemoglobin (HbA1c) ≥5.6%, systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg, high-density lipoprotein-cholesterol (HDL-C) ≤1.03 mmol/l for men and ≤1.29 mmol/l for women and triglyceride ≥1.69 mmol/l. Results: The logarithmically transformed age-adjusted serum NO x (lnNO x ) value was significantly higher in the low HDL-C group (1.76 ± 0.05 μmol/l; p < 0.05) than MetS component groups (1.65 ± 0.01 μmol/l) in men, but no difference was found in women. The means of serum lnNO x after multivariate adjustment were 1.64, 1.65, 1.64, 1.66, and 1.81 μmol/l for 0, 1, 2, 3, and 4-5 MetS components for all subjects, respectively. The results of ANCOVA confirmed that the serum lnNO x level was significantly correlated with the clustering of MetS components in both men and women (p < 0.0001 for trend). Conclusion: Our results suggest that an increase in the clustering of MetS components was associated with the increase in serum NO levels in our general population.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalEnvironmental Health and Preventive Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 01-01-2008

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Cluster Analysis
Japan
Serum
Population
Blood Pressure
HDL Cholesterol
Social Adjustment
Glycosylated Hemoglobin A
Nitrites
Alcohol Drinking
Nitrates
LDL Cholesterol
Triglycerides
Body Mass Index
Biomarkers
Smoking
Exercise

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Ueyama, Jun ; Kondo, Takaaki ; Imai, Ryota ; Kimata, Akiko ; Yamamoto, Kanami ; Suzuki, Koji ; Inoue, Takashi ; Ito, Yoshinori ; Miyamoto, Ken Ichi ; Hasegawa, Takaaki ; Hamajima, Nobuyuki. / Association of serum NO x level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan In: Environmental Health and Preventive Medicine. 2008 ; Vol. 13, No. 1. pp. 36-42.
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abstract = "Objectives: The aim of this study was to determine whether the serum nitrite plus nitrate (NO x ) level correlates with biomarkers that are known components of the metabolic syndrome (MetS). Methods: Serum NO x levels were measured using a commercial kit in 608 Japanese men and women between the ages of 39 and 85 years. Multivariate adjustments for age, smoking status, alcohol consumption and exercise were made in the analysis of covariance (ANCOVA). The components of the metabolic syndrome were defined based on the following criteria: body mass index (BMI) ≥25.0 kg/m 2 , glycated hemoglobin (HbA1c) ≥5.6{\%}, systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg, high-density lipoprotein-cholesterol (HDL-C) ≤1.03 mmol/l for men and ≤1.29 mmol/l for women and triglyceride ≥1.69 mmol/l. Results: The logarithmically transformed age-adjusted serum NO x (lnNO x ) value was significantly higher in the low HDL-C group (1.76 ± 0.05 μmol/l; p < 0.05) than MetS component groups (1.65 ± 0.01 μmol/l) in men, but no difference was found in women. The means of serum lnNO x after multivariate adjustment were 1.64, 1.65, 1.64, 1.66, and 1.81 μmol/l for 0, 1, 2, 3, and 4-5 MetS components for all subjects, respectively. The results of ANCOVA confirmed that the serum lnNO x level was significantly correlated with the clustering of MetS components in both men and women (p < 0.0001 for trend). Conclusion: Our results suggest that an increase in the clustering of MetS components was associated with the increase in serum NO levels in our general population.",
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Association of serum NO x level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan . / Ueyama, Jun; Kondo, Takaaki; Imai, Ryota; Kimata, Akiko; Yamamoto, Kanami; Suzuki, Koji; Inoue, Takashi; Ito, Yoshinori; Miyamoto, Ken Ichi; Hasegawa, Takaaki; Hamajima, Nobuyuki.

In: Environmental Health and Preventive Medicine, Vol. 13, No. 1, 01.01.2008, p. 36-42.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of serum NO x level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan

AU - Ueyama, Jun

AU - Kondo, Takaaki

AU - Imai, Ryota

AU - Kimata, Akiko

AU - Yamamoto, Kanami

AU - Suzuki, Koji

AU - Inoue, Takashi

AU - Ito, Yoshinori

AU - Miyamoto, Ken Ichi

AU - Hasegawa, Takaaki

AU - Hamajima, Nobuyuki

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Objectives: The aim of this study was to determine whether the serum nitrite plus nitrate (NO x ) level correlates with biomarkers that are known components of the metabolic syndrome (MetS). Methods: Serum NO x levels were measured using a commercial kit in 608 Japanese men and women between the ages of 39 and 85 years. Multivariate adjustments for age, smoking status, alcohol consumption and exercise were made in the analysis of covariance (ANCOVA). The components of the metabolic syndrome were defined based on the following criteria: body mass index (BMI) ≥25.0 kg/m 2 , glycated hemoglobin (HbA1c) ≥5.6%, systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg, high-density lipoprotein-cholesterol (HDL-C) ≤1.03 mmol/l for men and ≤1.29 mmol/l for women and triglyceride ≥1.69 mmol/l. Results: The logarithmically transformed age-adjusted serum NO x (lnNO x ) value was significantly higher in the low HDL-C group (1.76 ± 0.05 μmol/l; p < 0.05) than MetS component groups (1.65 ± 0.01 μmol/l) in men, but no difference was found in women. The means of serum lnNO x after multivariate adjustment were 1.64, 1.65, 1.64, 1.66, and 1.81 μmol/l for 0, 1, 2, 3, and 4-5 MetS components for all subjects, respectively. The results of ANCOVA confirmed that the serum lnNO x level was significantly correlated with the clustering of MetS components in both men and women (p < 0.0001 for trend). Conclusion: Our results suggest that an increase in the clustering of MetS components was associated with the increase in serum NO levels in our general population.

AB - Objectives: The aim of this study was to determine whether the serum nitrite plus nitrate (NO x ) level correlates with biomarkers that are known components of the metabolic syndrome (MetS). Methods: Serum NO x levels were measured using a commercial kit in 608 Japanese men and women between the ages of 39 and 85 years. Multivariate adjustments for age, smoking status, alcohol consumption and exercise were made in the analysis of covariance (ANCOVA). The components of the metabolic syndrome were defined based on the following criteria: body mass index (BMI) ≥25.0 kg/m 2 , glycated hemoglobin (HbA1c) ≥5.6%, systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg, high-density lipoprotein-cholesterol (HDL-C) ≤1.03 mmol/l for men and ≤1.29 mmol/l for women and triglyceride ≥1.69 mmol/l. Results: The logarithmically transformed age-adjusted serum NO x (lnNO x ) value was significantly higher in the low HDL-C group (1.76 ± 0.05 μmol/l; p < 0.05) than MetS component groups (1.65 ± 0.01 μmol/l) in men, but no difference was found in women. The means of serum lnNO x after multivariate adjustment were 1.64, 1.65, 1.64, 1.66, and 1.81 μmol/l for 0, 1, 2, 3, and 4-5 MetS components for all subjects, respectively. The results of ANCOVA confirmed that the serum lnNO x level was significantly correlated with the clustering of MetS components in both men and women (p < 0.0001 for trend). Conclusion: Our results suggest that an increase in the clustering of MetS components was associated with the increase in serum NO levels in our general population.

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