Association of serum oxidized lipoprotein(a) concentration with coronary artery disease: Potential role of oxidized lipoprotein(a) in the vasucular wall

Ryuichi Morishita, Junichi Ishii, Yoshiaki Kusumi, Shingo Yamada, Norio Komai, Minoru Ohishi, Masanori Nomura, Hitoshi Hishida, Mari Niihashi, Masako Mitsumata

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Abstract

Aim: A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. Methods: We measured serum levels of oxidized Lp(a), Lp(a), LDL-cholesterol and HDL-cholesterol in 122 consecutive patients who underwent routine coronary angiography and had significant coronary artery stenosis (>75%), and 164 age-matched healthy volunteers. Moreover, serum native Lp(a), oxidized Lp(a) concentration, and pulse wave velocity (PWV) were determined in 181 hypertensive patients. Results: Oxidized Lp(a) level in CAD patients with DM was significantly higher than in healthy volunteers (p < 0.01). Moreover, serum oxidized Lp(a) concentration showed a significant positive correlation with pulse wave velocity, an index of arteriosclerosis (r = 0.431, p < 0.01). Of importance, the deposition of oxidized Lp(a) was readily detected in calcified areas of coronary arteries in patients with myocardial infarction. Conclusion: The present study demonstrated that oxidized Lp(a) may be a new risk factor for coronary artery disease. As the deposition of oxidized Lp(a) was detected in calcified areas of coronary arteries, oxidized Lp(a) might be implicated in endothelial dysfunction.

Original languageEnglish
Pages (from-to)410-418
Number of pages9
JournalJournal of Atherosclerosis and Thrombosis
Volume16
Issue number4
DOIs
Publication statusPublished - 01-01-2009

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Lipoprotein(a)
Coronary Artery Disease
Medical problems
Serum
Healthy Volunteers
Pulse Wave Analysis
Angiography
Coronary Vessels
Diabetes Mellitus
LDL Cholesterol
HDL Cholesterol
Epitopes
Arteriosclerosis
Coronary Stenosis
Oxidation
Coronary Angiography
Antibodies
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Morishita, Ryuichi ; Ishii, Junichi ; Kusumi, Yoshiaki ; Yamada, Shingo ; Komai, Norio ; Ohishi, Minoru ; Nomura, Masanori ; Hishida, Hitoshi ; Niihashi, Mari ; Mitsumata, Masako. / Association of serum oxidized lipoprotein(a) concentration with coronary artery disease : Potential role of oxidized lipoprotein(a) in the vasucular wall. In: Journal of Atherosclerosis and Thrombosis. 2009 ; Vol. 16, No. 4. pp. 410-418.
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abstract = "Aim: A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. Methods: We measured serum levels of oxidized Lp(a), Lp(a), LDL-cholesterol and HDL-cholesterol in 122 consecutive patients who underwent routine coronary angiography and had significant coronary artery stenosis (>75{\%}), and 164 age-matched healthy volunteers. Moreover, serum native Lp(a), oxidized Lp(a) concentration, and pulse wave velocity (PWV) were determined in 181 hypertensive patients. Results: Oxidized Lp(a) level in CAD patients with DM was significantly higher than in healthy volunteers (p < 0.01). Moreover, serum oxidized Lp(a) concentration showed a significant positive correlation with pulse wave velocity, an index of arteriosclerosis (r = 0.431, p < 0.01). Of importance, the deposition of oxidized Lp(a) was readily detected in calcified areas of coronary arteries in patients with myocardial infarction. Conclusion: The present study demonstrated that oxidized Lp(a) may be a new risk factor for coronary artery disease. As the deposition of oxidized Lp(a) was detected in calcified areas of coronary arteries, oxidized Lp(a) might be implicated in endothelial dysfunction.",
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Association of serum oxidized lipoprotein(a) concentration with coronary artery disease : Potential role of oxidized lipoprotein(a) in the vasucular wall. / Morishita, Ryuichi; Ishii, Junichi; Kusumi, Yoshiaki; Yamada, Shingo; Komai, Norio; Ohishi, Minoru; Nomura, Masanori; Hishida, Hitoshi; Niihashi, Mari; Mitsumata, Masako.

In: Journal of Atherosclerosis and Thrombosis, Vol. 16, No. 4, 01.01.2009, p. 410-418.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of serum oxidized lipoprotein(a) concentration with coronary artery disease

T2 - Potential role of oxidized lipoprotein(a) in the vasucular wall

AU - Morishita, Ryuichi

AU - Ishii, Junichi

AU - Kusumi, Yoshiaki

AU - Yamada, Shingo

AU - Komai, Norio

AU - Ohishi, Minoru

AU - Nomura, Masanori

AU - Hishida, Hitoshi

AU - Niihashi, Mari

AU - Mitsumata, Masako

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Aim: A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. Methods: We measured serum levels of oxidized Lp(a), Lp(a), LDL-cholesterol and HDL-cholesterol in 122 consecutive patients who underwent routine coronary angiography and had significant coronary artery stenosis (>75%), and 164 age-matched healthy volunteers. Moreover, serum native Lp(a), oxidized Lp(a) concentration, and pulse wave velocity (PWV) were determined in 181 hypertensive patients. Results: Oxidized Lp(a) level in CAD patients with DM was significantly higher than in healthy volunteers (p < 0.01). Moreover, serum oxidized Lp(a) concentration showed a significant positive correlation with pulse wave velocity, an index of arteriosclerosis (r = 0.431, p < 0.01). Of importance, the deposition of oxidized Lp(a) was readily detected in calcified areas of coronary arteries in patients with myocardial infarction. Conclusion: The present study demonstrated that oxidized Lp(a) may be a new risk factor for coronary artery disease. As the deposition of oxidized Lp(a) was detected in calcified areas of coronary arteries, oxidized Lp(a) might be implicated in endothelial dysfunction.

AB - Aim: A new antibody reacted with an epitope in Lp(a) that has undergone oxidation treatment, but is not present in native Lp(a), was developed. Thus, we determined serum oxidized Lp(a) concentration in healthy volunteers, and coronary artery disease (CAD), diabetes mellitus (DM), and hypertensive patients. Methods: We measured serum levels of oxidized Lp(a), Lp(a), LDL-cholesterol and HDL-cholesterol in 122 consecutive patients who underwent routine coronary angiography and had significant coronary artery stenosis (>75%), and 164 age-matched healthy volunteers. Moreover, serum native Lp(a), oxidized Lp(a) concentration, and pulse wave velocity (PWV) were determined in 181 hypertensive patients. Results: Oxidized Lp(a) level in CAD patients with DM was significantly higher than in healthy volunteers (p < 0.01). Moreover, serum oxidized Lp(a) concentration showed a significant positive correlation with pulse wave velocity, an index of arteriosclerosis (r = 0.431, p < 0.01). Of importance, the deposition of oxidized Lp(a) was readily detected in calcified areas of coronary arteries in patients with myocardial infarction. Conclusion: The present study demonstrated that oxidized Lp(a) may be a new risk factor for coronary artery disease. As the deposition of oxidized Lp(a) was detected in calcified areas of coronary arteries, oxidized Lp(a) might be implicated in endothelial dysfunction.

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