Association of Serum Retinol and Carotenoids with Insulinlike Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC study

Koji Suzuki, Yoshinori Ito, Shuji Hashimoto, Miyuki Kawado, Takashi Inoue, Masahiko Ando, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu HoshiyamaNaohito Tanabe, Koji Tamakoshi, Kenji Wakai, Shinkan Tokudome, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival, and thus are thought to be important for tumor development. Carotenoids and retinol have been linked to the prevention of several cancers. We here evaluated associations of serum levels of carotenoids and retinol with IGF-I, IGF-II, and IGFBP-3 within the context of the JACC Study. The study subjects were 924 controls (578 men and 346 women) of a nested case-control study of lung and colorectal cancer risk. Using frozen-stored sera, serum levels of α-carotene, β-carotene, lycopene, β-cryptoxanthin, zeaxanthin/lutein, and retinol were separately determined using high-performance liquid chromatography. Serum levels of IGF-I, IGF-II, and IGFBP-3 were measured by immuno-radiometric assay. Confounding factors-adjusted least squares mean levels of serum IGFI, IGF-II, and IGFBP-3 for each quartile of serum levels of carotenoids and retinol were estimated. Serum IGFI, IGF-II, and IGFBP-3 levels increased with increasing serum retinol levels. Moreover, serum IGF-I levels were significantly higher in highest quartile of serum provitamin A, such as α-carotene, β-carotene, and β-cryptoxanthin, among women. Serum IGFBP-3 levels decreased with increasing serum lycopene levels in women and with increasing serum zeaxanthin/lutein levels in men. The current study indicates that positive associations exist for serum retinol levels with serum levels of IGF-I, IGF-II, and IGFBP-3 independent of age, BMI, smoking habits, drinking habits, and intake of energy and protein among Japanese healthy men and women.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 12-2009

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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    Suzuki, K., Ito, Y., Hashimoto, S., Kawado, M., Inoue, T., Ando, M., Watanabe, Y., Inaba, Y., Tajima, K., Nakachi, K., Tamakoshi, A., Mori, M., Sakauchi, F., Motohashi, Y., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Kurosawa, M., ... Shio, H. (2009). Association of Serum Retinol and Carotenoids with Insulinlike Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC study. Asian Pacific Journal of Cancer Prevention, 10(SUPPL.1), 29-36.