Association of Serum Retinol and Carotenoids with Insulinlike Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC study

Koji Suzuki, Yoshinori Ito, Shuji Hashimoto, Miyuki Kawado, Takashi Inoue, Masahiko Ando, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu HoshiyamaNaohito Tanabe, Koji Tamakoshi, Kenji Wakai, Shinkan Tokudome, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival, and thus are thought to be important for tumor development. Carotenoids and retinol have been linked to the prevention of several cancers. We here evaluated associations of serum levels of carotenoids and retinol with IGF-I, IGF-II, and IGFBP-3 within the context of the JACC Study. The study subjects were 924 controls (578 men and 346 women) of a nested case-control study of lung and colorectal cancer risk. Using frozen-stored sera, serum levels of α-carotene, β-carotene, lycopene, β-cryptoxanthin, zeaxanthin/lutein, and retinol were separately determined using high-performance liquid chromatography. Serum levels of IGF-I, IGF-II, and IGFBP-3 were measured by immuno-radiometric assay. Confounding factors-adjusted least squares mean levels of serum IGFI, IGF-II, and IGFBP-3 for each quartile of serum levels of carotenoids and retinol were estimated. Serum IGFI, IGF-II, and IGFBP-3 levels increased with increasing serum retinol levels. Moreover, serum IGF-I levels were significantly higher in highest quartile of serum provitamin A, such as α-carotene, β-carotene, and β-cryptoxanthin, among women. Serum IGFBP-3 levels decreased with increasing serum lycopene levels in women and with increasing serum zeaxanthin/lutein levels in men. The current study indicates that positive associations exist for serum retinol levels with serum levels of IGF-I, IGF-II, and IGFBP-3 independent of age, BMI, smoking habits, drinking habits, and intake of energy and protein among Japanese healthy men and women.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 01-01-2009

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Insulin-Like Growth Factor Binding Protein 3
Carotenoids
Vitamin A
Case-Control Studies
Intercellular Signaling Peptides and Proteins
Serum
Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Lutein
Habits
Energy Intake
Least-Squares Analysis

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Suzuki, Koji ; Ito, Yoshinori ; Hashimoto, Shuji ; Kawado, Miyuki ; Inoue, Takashi ; Ando, Masahiko ; Watanabe, Yoshiyuki ; Inaba, Yutaka ; Tajima, Kazuo ; Nakachi, Kei ; Tamakoshi, Akiko ; Mori, Mitsuru ; Sakauchi, Fumio ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Tamakoshi, Koji ; Wakai, Kenji ; Tokudome, Shinkan ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Yoshimura, Takesumi ; Fujino, Yoshihisa ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo. / Association of Serum Retinol and Carotenoids with Insulinlike Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC study. In: Asian Pacific Journal of Cancer Prevention. 2009 ; Vol. 10, No. SUPPL.1. pp. 29-36.
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title = "Association of Serum Retinol and Carotenoids with Insulinlike Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC study",
abstract = "Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival, and thus are thought to be important for tumor development. Carotenoids and retinol have been linked to the prevention of several cancers. We here evaluated associations of serum levels of carotenoids and retinol with IGF-I, IGF-II, and IGFBP-3 within the context of the JACC Study. The study subjects were 924 controls (578 men and 346 women) of a nested case-control study of lung and colorectal cancer risk. Using frozen-stored sera, serum levels of α-carotene, β-carotene, lycopene, β-cryptoxanthin, zeaxanthin/lutein, and retinol were separately determined using high-performance liquid chromatography. Serum levels of IGF-I, IGF-II, and IGFBP-3 were measured by immuno-radiometric assay. Confounding factors-adjusted least squares mean levels of serum IGFI, IGF-II, and IGFBP-3 for each quartile of serum levels of carotenoids and retinol were estimated. Serum IGFI, IGF-II, and IGFBP-3 levels increased with increasing serum retinol levels. Moreover, serum IGF-I levels were significantly higher in highest quartile of serum provitamin A, such as α-carotene, β-carotene, and β-cryptoxanthin, among women. Serum IGFBP-3 levels decreased with increasing serum lycopene levels in women and with increasing serum zeaxanthin/lutein levels in men. The current study indicates that positive associations exist for serum retinol levels with serum levels of IGF-I, IGF-II, and IGFBP-3 independent of age, BMI, smoking habits, drinking habits, and intake of energy and protein among Japanese healthy men and women.",
author = "Koji Suzuki and Yoshinori Ito and Shuji Hashimoto and Miyuki Kawado and Takashi Inoue and Masahiko Ando and Yoshiyuki Watanabe and Yutaka Inaba and Kazuo Tajima and Kei Nakachi and Akiko Tamakoshi and Mitsuru Mori and Fumio Sakauchi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Kenji Wakai and Shinkan Tokudome and Shogo Kikuchi and Yasuhiko Wada and Takashi Kawamura and Yoshiyuki Watanabe and Kotaro Ozasa and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Takesumi Yoshimura and Yoshihisa Fujino and Akira Shibata and Naoyuki Okamoto and Hideo Shio",
year = "2009",
month = "1",
day = "1",
language = "English",
volume = "10",
pages = "29--36",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "SUPPL.1",

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Suzuki, K, Ito, Y, Hashimoto, S, Kawado, M, Inoue, T, Ando, M, Watanabe, Y, Inaba, Y, Tajima, K, Nakachi, K, Tamakoshi, A, Mori, M, Sakauchi, F, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Tamakoshi, K, Wakai, K, Tokudome, S, Kikuchi, S, Wada, Y, Kawamura, T, Watanabe, Y, Ozasa, K, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Yoshimura, T, Fujino, Y, Shibata, A, Okamoto, N & Shio, H 2009, 'Association of Serum Retinol and Carotenoids with Insulinlike Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC study', Asian Pacific Journal of Cancer Prevention, vol. 10, no. SUPPL.1, pp. 29-36.

Association of Serum Retinol and Carotenoids with Insulinlike Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC study. / Suzuki, Koji; Ito, Yoshinori; Hashimoto, Shuji; Kawado, Miyuki; Inoue, Takashi; Ando, Masahiko; Watanabe, Yoshiyuki; Inaba, Yutaka; Tajima, Kazuo; Nakachi, Kei; Tamakoshi, Akiko; Mori, Mitsuru; Sakauchi, Fumio; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Tamakoshi, Koji; Wakai, Kenji; Tokudome, Shinkan; Kikuchi, Shogo; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Yoshimura, Takesumi; Fujino, Yoshihisa; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo.

In: Asian Pacific Journal of Cancer Prevention, Vol. 10, No. SUPPL.1, 01.01.2009, p. 29-36.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of Serum Retinol and Carotenoids with Insulinlike Growth Factors and Insulin-like Growth Factor Binding Protein-3 among Control Subjects of a Nested Case-control Study in the JACC study

AU - Suzuki, Koji

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Kawado, Miyuki

AU - Inoue, Takashi

AU - Ando, Masahiko

AU - Watanabe, Yoshiyuki

AU - Inaba, Yutaka

AU - Tajima, Kazuo

AU - Nakachi, Kei

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival, and thus are thought to be important for tumor development. Carotenoids and retinol have been linked to the prevention of several cancers. We here evaluated associations of serum levels of carotenoids and retinol with IGF-I, IGF-II, and IGFBP-3 within the context of the JACC Study. The study subjects were 924 controls (578 men and 346 women) of a nested case-control study of lung and colorectal cancer risk. Using frozen-stored sera, serum levels of α-carotene, β-carotene, lycopene, β-cryptoxanthin, zeaxanthin/lutein, and retinol were separately determined using high-performance liquid chromatography. Serum levels of IGF-I, IGF-II, and IGFBP-3 were measured by immuno-radiometric assay. Confounding factors-adjusted least squares mean levels of serum IGFI, IGF-II, and IGFBP-3 for each quartile of serum levels of carotenoids and retinol were estimated. Serum IGFI, IGF-II, and IGFBP-3 levels increased with increasing serum retinol levels. Moreover, serum IGF-I levels were significantly higher in highest quartile of serum provitamin A, such as α-carotene, β-carotene, and β-cryptoxanthin, among women. Serum IGFBP-3 levels decreased with increasing serum lycopene levels in women and with increasing serum zeaxanthin/lutein levels in men. The current study indicates that positive associations exist for serum retinol levels with serum levels of IGF-I, IGF-II, and IGFBP-3 independent of age, BMI, smoking habits, drinking habits, and intake of energy and protein among Japanese healthy men and women.

AB - Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival, and thus are thought to be important for tumor development. Carotenoids and retinol have been linked to the prevention of several cancers. We here evaluated associations of serum levels of carotenoids and retinol with IGF-I, IGF-II, and IGFBP-3 within the context of the JACC Study. The study subjects were 924 controls (578 men and 346 women) of a nested case-control study of lung and colorectal cancer risk. Using frozen-stored sera, serum levels of α-carotene, β-carotene, lycopene, β-cryptoxanthin, zeaxanthin/lutein, and retinol were separately determined using high-performance liquid chromatography. Serum levels of IGF-I, IGF-II, and IGFBP-3 were measured by immuno-radiometric assay. Confounding factors-adjusted least squares mean levels of serum IGFI, IGF-II, and IGFBP-3 for each quartile of serum levels of carotenoids and retinol were estimated. Serum IGFI, IGF-II, and IGFBP-3 levels increased with increasing serum retinol levels. Moreover, serum IGF-I levels were significantly higher in highest quartile of serum provitamin A, such as α-carotene, β-carotene, and β-cryptoxanthin, among women. Serum IGFBP-3 levels decreased with increasing serum lycopene levels in women and with increasing serum zeaxanthin/lutein levels in men. The current study indicates that positive associations exist for serum retinol levels with serum levels of IGF-I, IGF-II, and IGFBP-3 independent of age, BMI, smoking habits, drinking habits, and intake of energy and protein among Japanese healthy men and women.

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