Association of SOX10 with schizophrenia in the Japanese population

Nobuhisa Maeno, Nagahide Takahashi, Shinichi Saito, Xiaofei Ji, Ryoko Ishihara, Nagisa Aoyama, Aleksic Branko, Hideki Miura, Masashi Ikeda, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Nakao Iwata, Toshiya Inada, Norio Ozaki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

BACKGROUND: Microarray studies of schizophrenic brains revealed decreases in the expression of myelin and oligodendrocyte-related genes. Of these genes, sex-determining region Y-box 10 (SOX10) is a major transcription factor modulating the expression of proteins involved in neurogenesis and myelination. The SOX10 gene is located on chromosome 22q13.1, a region repeatedly reported to show positive signals in linkage studies on schizophrenia. OBJECTIVE: This study was conducted to clarify the exact role of SOX10 in the pathophysiology of schizophrenia. METHODS: We performed an association analysis of SOX10 in a Japanese population of 915 schizophrenic patients and 927 controls. Genotyping was carried out using polymerase chain reaction restriction fragment length polymorphism. MAIN RESULTS: One single nucleotide polymorphism of the SOX10 gene (rs139887) was selected as a haplotype tag single nucleotide polymorphism using 96 controls. A significant association was observed in the genotype and allelic frequency of this single nucleotide polymorphism between schizophrenic patients and controls (P=0.025 and P=0.009, respectively). Especially, a significant association was found in male patients, but not female patients. We also performed a mutational search of the whole coding region, branch site, and promoter region of SOX10 in 96 schizophrenic patients, but no potential functional polymorphisms were detected. CONCLUSION: This study suggests that the SOX10 gene is related to the development of schizophrenia in the Japanese population.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalPsychiatric Genetics
Volume17
Issue number4
DOIs
Publication statusPublished - 01-08-2007

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Schizophrenia
Single Nucleotide Polymorphism
Population
Genes
sry Genes
Neurogenesis
Oligodendroglia
Myelin Sheath
Genetic Promoter Regions
Restriction Fragment Length Polymorphisms
Haplotypes
Transcription Factors
Chromosomes
Genotype
Polymerase Chain Reaction
Brain
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Maeno, N., Takahashi, N., Saito, S., Ji, X., Ishihara, R., Aoyama, N., ... Ozaki, N. (2007). Association of SOX10 with schizophrenia in the Japanese population. Psychiatric Genetics, 17(4), 227-231. https://doi.org/10.1097/YPG.0b013e3280ae6cd8
Maeno, Nobuhisa ; Takahashi, Nagahide ; Saito, Shinichi ; Ji, Xiaofei ; Ishihara, Ryoko ; Aoyama, Nagisa ; Branko, Aleksic ; Miura, Hideki ; Ikeda, Masashi ; Suzuki, Tatsuyo ; Kitajima, Tsuyoshi ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Iwata, Nakao ; Inada, Toshiya ; Ozaki, Norio. / Association of SOX10 with schizophrenia in the Japanese population. In: Psychiatric Genetics. 2007 ; Vol. 17, No. 4. pp. 227-231.
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Maeno, N, Takahashi, N, Saito, S, Ji, X, Ishihara, R, Aoyama, N, Branko, A, Miura, H, Ikeda, M, Suzuki, T, Kitajima, T, Yamanouchi, Y, Kinoshita, Y, Iwata, N, Inada, T & Ozaki, N 2007, 'Association of SOX10 with schizophrenia in the Japanese population', Psychiatric Genetics, vol. 17, no. 4, pp. 227-231. https://doi.org/10.1097/YPG.0b013e3280ae6cd8

Association of SOX10 with schizophrenia in the Japanese population. / Maeno, Nobuhisa; Takahashi, Nagahide; Saito, Shinichi; Ji, Xiaofei; Ishihara, Ryoko; Aoyama, Nagisa; Branko, Aleksic; Miura, Hideki; Ikeda, Masashi; Suzuki, Tatsuyo; Kitajima, Tsuyoshi; Yamanouchi, Yoshio; Kinoshita, Yoko; Iwata, Nakao; Inada, Toshiya; Ozaki, Norio.

In: Psychiatric Genetics, Vol. 17, No. 4, 01.08.2007, p. 227-231.

Research output: Contribution to journalArticle

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T1 - Association of SOX10 with schizophrenia in the Japanese population

AU - Maeno, Nobuhisa

AU - Takahashi, Nagahide

AU - Saito, Shinichi

AU - Ji, Xiaofei

AU - Ishihara, Ryoko

AU - Aoyama, Nagisa

AU - Branko, Aleksic

AU - Miura, Hideki

AU - Ikeda, Masashi

AU - Suzuki, Tatsuyo

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Iwata, Nakao

AU - Inada, Toshiya

AU - Ozaki, Norio

PY - 2007/8/1

Y1 - 2007/8/1

N2 - BACKGROUND: Microarray studies of schizophrenic brains revealed decreases in the expression of myelin and oligodendrocyte-related genes. Of these genes, sex-determining region Y-box 10 (SOX10) is a major transcription factor modulating the expression of proteins involved in neurogenesis and myelination. The SOX10 gene is located on chromosome 22q13.1, a region repeatedly reported to show positive signals in linkage studies on schizophrenia. OBJECTIVE: This study was conducted to clarify the exact role of SOX10 in the pathophysiology of schizophrenia. METHODS: We performed an association analysis of SOX10 in a Japanese population of 915 schizophrenic patients and 927 controls. Genotyping was carried out using polymerase chain reaction restriction fragment length polymorphism. MAIN RESULTS: One single nucleotide polymorphism of the SOX10 gene (rs139887) was selected as a haplotype tag single nucleotide polymorphism using 96 controls. A significant association was observed in the genotype and allelic frequency of this single nucleotide polymorphism between schizophrenic patients and controls (P=0.025 and P=0.009, respectively). Especially, a significant association was found in male patients, but not female patients. We also performed a mutational search of the whole coding region, branch site, and promoter region of SOX10 in 96 schizophrenic patients, but no potential functional polymorphisms were detected. CONCLUSION: This study suggests that the SOX10 gene is related to the development of schizophrenia in the Japanese population.

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Maeno N, Takahashi N, Saito S, Ji X, Ishihara R, Aoyama N et al. Association of SOX10 with schizophrenia in the Japanese population. Psychiatric Genetics. 2007 Aug 1;17(4):227-231. https://doi.org/10.1097/YPG.0b013e3280ae6cd8