Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy

Taro Matsui; Yukihiro Hamada; Motoi Kuwahara; Jyoji Morise; Shogo Oka; Kenichi Kaida; Susumu Kusunoki

doi:10.1016/j.jneuroim.2019.577127

Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy

Taro Matsui, Yukihiro Hamada, Motoi Kuwahara, Jyoji Morise, Shogo Oka, Kenichi Kaida, Susumu Kusunoki

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Anti-myelin-associated glycoprotein (MAG) neuropathy is mediated by the binding of IgM M-proteins to the human natural killer-1 epitope of several glycoconjugates, including MAG and phosphacan. We recently reported that IgM M-proteins with a higher ratio of anti-phosphacan titer to anti-MAG titer (P/M ratio) were associated with a progressive clinical course. Herein, we investigated the temporal variability of the P/M ratio. The results showed that P/M ratios in worsened cases were significantly increased relative to stable or improved cases. Thus, temporal variability in the specificity of IgM M-proteins may be related to the disease course of anti-MAG neuropathy.

Original language	English
Article number	577127
Journal	Journal of Neuroimmunology
Volume	339
DOIs	https://doi.org/10.1016/j.jneuroim.2019.577127
Publication status	Published - 15-02-2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jneuroim.2019.577127

Cite this

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title = "Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy",

abstract = "Anti-myelin-associated glycoprotein (MAG) neuropathy is mediated by the binding of IgM M-proteins to the human natural killer-1 epitope of several glycoconjugates, including MAG and phosphacan. We recently reported that IgM M-proteins with a higher ratio of anti-phosphacan titer to anti-MAG titer (P/M ratio) were associated with a progressive clinical course. Herein, we investigated the temporal variability of the P/M ratio. The results showed that P/M ratios in worsened cases were significantly increased relative to stable or improved cases. Thus, temporal variability in the specificity of IgM M-proteins may be related to the disease course of anti-MAG neuropathy.",

keywords = "Anti-MAG neuropathy, MAG, P/M ratio, Phosphacan, Prognosis",

author = "Taro Matsui and Yukihiro Hamada and Motoi Kuwahara and Jyoji Morise and Shogo Oka and Kenichi Kaida and Susumu Kusunoki",

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doi = "10.1016/j.jneuroim.2019.577127",

language = "English",

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T1 - Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy

AU - Matsui, Taro

AU - Hamada, Yukihiro

AU - Kuwahara, Motoi

AU - Morise, Jyoji

AU - Oka, Shogo

AU - Kaida, Kenichi

AU - Kusunoki, Susumu

PY - 2020/2/15

Y1 - 2020/2/15

N2 - Anti-myelin-associated glycoprotein (MAG) neuropathy is mediated by the binding of IgM M-proteins to the human natural killer-1 epitope of several glycoconjugates, including MAG and phosphacan. We recently reported that IgM M-proteins with a higher ratio of anti-phosphacan titer to anti-MAG titer (P/M ratio) were associated with a progressive clinical course. Herein, we investigated the temporal variability of the P/M ratio. The results showed that P/M ratios in worsened cases were significantly increased relative to stable or improved cases. Thus, temporal variability in the specificity of IgM M-proteins may be related to the disease course of anti-MAG neuropathy.

AB - Anti-myelin-associated glycoprotein (MAG) neuropathy is mediated by the binding of IgM M-proteins to the human natural killer-1 epitope of several glycoconjugates, including MAG and phosphacan. We recently reported that IgM M-proteins with a higher ratio of anti-phosphacan titer to anti-MAG titer (P/M ratio) were associated with a progressive clinical course. Herein, we investigated the temporal variability of the P/M ratio. The results showed that P/M ratios in worsened cases were significantly increased relative to stable or improved cases. Thus, temporal variability in the specificity of IgM M-proteins may be related to the disease course of anti-MAG neuropathy.

KW - Anti-MAG neuropathy

KW - MAG

KW - P/M ratio

KW - Phosphacan

KW - Prognosis

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Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy

Abstract

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UN SDGs

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