TY - JOUR
T1 - Association of vegetable, fruit, and okinawan vegetable consumption with incident stroke and coronary heart disease
AU - JPHC Study Group
AU - Yoshizaki, Takahiro
AU - Ishihara, Junko
AU - Kotemori, Ayaka
AU - Yamamoto, Junpei
AU - Kokubo, Yoshihiro
AU - Saito, Isao
AU - Yatsuya, Hiroshi
AU - Yamagishi, Kazumasa
AU - Sawada, Norie
AU - Iwasaki, Motoki
AU - Iso, Hiroyasu
AU - Tsugane, Shoichiro
N1 - Funding Information:
Funding: This study was supported by a grant from the National Cancer Center Research and Development Fund (since 2011; the principal investigator is ST), a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (1989–2010; the principal investigator from 1997 to 2010 was ST), and a Grant-in-Aid from the Ministry of Agriculture, Forestry and Fisheries (MAFF-CPS-2016-1-1). Conflicts of interest: None declared.
PY - 2020
Y1 - 2020
N2 - Background: Few studies have investigated the effects of Okinawan vegetable consumption on the risk of incident stroke and coronary heart disease. This study aimed to examine associations of vegetable, fruit, and Okinawan vegetable consumption with risk of incident stroke and coronary heart disease in the Japanese population of Okinawa. Methods: The study design was a prospective cohort study. During 1995–1998, a validated food frequency questionnaire was administered in two study areas to 16,498 participants aged 45–74 years. In 217,467 person-years of follow-up until the end of 2012, a total of 839 stroke cases and 197 coronary heart disease cases were identified. Results: No statistically significant association between total Okinawan vegetable consumption and risk of stroke and coronary heart disease was obtained: the multivariable adjusted hazard ratios for the highest versus lowest tertile of consumption were 1.09 (95% confidence interval, 0.93–1.29; P for trend = 0.289) in model 2. Total vegetable and fruit and specific Okinawan vegetable consumption were also not statistically significantly associated with risk of cardiovascular outcomes. Conclusions: This study demonstrated that consumption of total vegetable and fruit, total Okinawan vegetables, and specific Okinawan vegetables in Japanese residents of Okinawa was not associated with risk of incident stroke and coronary heart disease.
AB - Background: Few studies have investigated the effects of Okinawan vegetable consumption on the risk of incident stroke and coronary heart disease. This study aimed to examine associations of vegetable, fruit, and Okinawan vegetable consumption with risk of incident stroke and coronary heart disease in the Japanese population of Okinawa. Methods: The study design was a prospective cohort study. During 1995–1998, a validated food frequency questionnaire was administered in two study areas to 16,498 participants aged 45–74 years. In 217,467 person-years of follow-up until the end of 2012, a total of 839 stroke cases and 197 coronary heart disease cases were identified. Results: No statistically significant association between total Okinawan vegetable consumption and risk of stroke and coronary heart disease was obtained: the multivariable adjusted hazard ratios for the highest versus lowest tertile of consumption were 1.09 (95% confidence interval, 0.93–1.29; P for trend = 0.289) in model 2. Total vegetable and fruit and specific Okinawan vegetable consumption were also not statistically significantly associated with risk of cardiovascular outcomes. Conclusions: This study demonstrated that consumption of total vegetable and fruit, total Okinawan vegetables, and specific Okinawan vegetables in Japanese residents of Okinawa was not associated with risk of incident stroke and coronary heart disease.
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U2 - 10.2188/jea.JE20180130
DO - 10.2188/jea.JE20180130
M3 - Article
C2 - 30643101
AN - SCOPUS:85078245670
VL - 30
SP - 37
EP - 45
JO - Journal of Epidemiology
JF - Journal of Epidemiology
SN - 0917-5040
IS - 1
ER -