Association of white blood cell count and clustered components of metabolic syndrome in Japanese men

Nobue Nagasawa, Koji Tamakoshi, Hiroshi Yatsuya, Yoko Hori, Miyuki Ishikawa, Chiyoe Murata, Huiming Zhang, Keiko Wada, Rei Otsuka, Tomoko Mabuchi, Takaaki Kondo, Hideaki Toyoshima

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background: The role of inflammation in the genesis of cardiovascular disease has attracted attention and in the present study the association among metabolic syndrome (MS), white blood cell (WBC) count, and insulin concentration was investigated. Methods and Results: A cross-sectional study of 3,594 Japanese men aged 34-69 years evaluated the MS components (high blood pressure, hypo-high density lipoprotein (HDL)-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults, except for obesity [body mass index (BMI) ≥25 kg/m2]. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucose and insulin, and a negative correlation with HDL-cholesterol. The multi-adjusted means of WBC count and insulin concentration were significantly higher in MS subjects defined as having 3 or more of the components than in non-MS subjects with no more than 2 components. Both means also increased with the number of MS components (p<0.001 for trend). In the multiple linear regression analysis, BMI, HDL-cholesterol, systolic blood pressure, glucose and triglyceride had a significant and independent association with WBC count, but the insulin concentration did not. Conclusions: The cluster of MS components based on insulin resistance may cause low-grade inflammation.

Original languageEnglish
Pages (from-to)892-897
Number of pages6
JournalCirculation Journal
Volume68
Issue number10
DOIs
Publication statusPublished - 01-10-2004

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Leukocyte Count
Insulin
Body Mass Index
Blood Pressure
HDL Cholesterol
Triglycerides
Cholesterol
Inflammation
Hypertriglyceridemia
HDL Lipoproteins
Hyperglycemia
Insulin Resistance
Blood Glucose
Linear Models
Cardiovascular Diseases
Obesity
Cross-Sectional Studies
Regression Analysis
Hypertension
Education

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Nagasawa, N., Tamakoshi, K., Yatsuya, H., Hori, Y., Ishikawa, M., Murata, C., ... Toyoshima, H. (2004). Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. Circulation Journal, 68(10), 892-897. https://doi.org/10.1253/circj.68.892
Nagasawa, Nobue ; Tamakoshi, Koji ; Yatsuya, Hiroshi ; Hori, Yoko ; Ishikawa, Miyuki ; Murata, Chiyoe ; Zhang, Huiming ; Wada, Keiko ; Otsuka, Rei ; Mabuchi, Tomoko ; Kondo, Takaaki ; Toyoshima, Hideaki. / Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. In: Circulation Journal. 2004 ; Vol. 68, No. 10. pp. 892-897.
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Nagasawa, N, Tamakoshi, K, Yatsuya, H, Hori, Y, Ishikawa, M, Murata, C, Zhang, H, Wada, K, Otsuka, R, Mabuchi, T, Kondo, T & Toyoshima, H 2004, 'Association of white blood cell count and clustered components of metabolic syndrome in Japanese men', Circulation Journal, vol. 68, no. 10, pp. 892-897. https://doi.org/10.1253/circj.68.892

Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. / Nagasawa, Nobue; Tamakoshi, Koji; Yatsuya, Hiroshi; Hori, Yoko; Ishikawa, Miyuki; Murata, Chiyoe; Zhang, Huiming; Wada, Keiko; Otsuka, Rei; Mabuchi, Tomoko; Kondo, Takaaki; Toyoshima, Hideaki.

In: Circulation Journal, Vol. 68, No. 10, 01.10.2004, p. 892-897.

Research output: Contribution to journalArticle

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T1 - Association of white blood cell count and clustered components of metabolic syndrome in Japanese men

AU - Nagasawa, Nobue

AU - Tamakoshi, Koji

AU - Yatsuya, Hiroshi

AU - Hori, Yoko

AU - Ishikawa, Miyuki

AU - Murata, Chiyoe

AU - Zhang, Huiming

AU - Wada, Keiko

AU - Otsuka, Rei

AU - Mabuchi, Tomoko

AU - Kondo, Takaaki

AU - Toyoshima, Hideaki

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Background: The role of inflammation in the genesis of cardiovascular disease has attracted attention and in the present study the association among metabolic syndrome (MS), white blood cell (WBC) count, and insulin concentration was investigated. Methods and Results: A cross-sectional study of 3,594 Japanese men aged 34-69 years evaluated the MS components (high blood pressure, hypo-high density lipoprotein (HDL)-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults, except for obesity [body mass index (BMI) ≥25 kg/m2]. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucose and insulin, and a negative correlation with HDL-cholesterol. The multi-adjusted means of WBC count and insulin concentration were significantly higher in MS subjects defined as having 3 or more of the components than in non-MS subjects with no more than 2 components. Both means also increased with the number of MS components (p<0.001 for trend). In the multiple linear regression analysis, BMI, HDL-cholesterol, systolic blood pressure, glucose and triglyceride had a significant and independent association with WBC count, but the insulin concentration did not. Conclusions: The cluster of MS components based on insulin resistance may cause low-grade inflammation.

AB - Background: The role of inflammation in the genesis of cardiovascular disease has attracted attention and in the present study the association among metabolic syndrome (MS), white blood cell (WBC) count, and insulin concentration was investigated. Methods and Results: A cross-sectional study of 3,594 Japanese men aged 34-69 years evaluated the MS components (high blood pressure, hypo-high density lipoprotein (HDL)-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults, except for obesity [body mass index (BMI) ≥25 kg/m2]. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucose and insulin, and a negative correlation with HDL-cholesterol. The multi-adjusted means of WBC count and insulin concentration were significantly higher in MS subjects defined as having 3 or more of the components than in non-MS subjects with no more than 2 components. Both means also increased with the number of MS components (p<0.001 for trend). In the multiple linear regression analysis, BMI, HDL-cholesterol, systolic blood pressure, glucose and triglyceride had a significant and independent association with WBC count, but the insulin concentration did not. Conclusions: The cluster of MS components based on insulin resistance may cause low-grade inflammation.

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