Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan

Kanako Itoh, Kenji Hashimoto, Eiji Shimizu, Yoshimoto Sekine, Norio Ozaki, Toshiya Inada, Mutsuo Harano, Nakao Iwata, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Kenji Nakata, Hiroshi Ujike, Masaomi Iyo

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Abstract

Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (C270T named formerly) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C > T in exon V: genotype, P = 0.586, allele, P = 0.594; 196G > A (val66met) in exon XIIIA: genotype, P = 0.889, allele, P = 0.713). Furthermore, there was no difference between clinical parameters (e.g., prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C > T in exon V and 196G > A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume132 B
Issue number1
DOIs
Publication statusPublished - 05-01-2005

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Itoh, K., Hashimoto, K., Shimizu, E., Sekine, Y., Ozaki, N., Inada, T., Harano, M., Iwata, N., Komiyama, T., Yamada, M., Sora, I., Nakata, K., Ujike, H., & Iyo, M. (2005). Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan. American Journal of Medical Genetics - Neuropsychiatric Genetics, 132 B(1), 70-73. https://doi.org/10.1002/ajmg.b.30097