TY - JOUR
T1 - Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population
AU - Aoyama, N.
AU - Takahashi, N.
AU - Saito, S.
AU - Maeno, N.
AU - Ishihara, R.
AU - Ji, X.
AU - Miura, H.
AU - Ikeda, M.
AU - Suzuki, T.
AU - Kitajima, T.
AU - Yamanouchi, Y.
AU - Kinoshita, Y.
AU - Yoshida, K.
AU - Iwata, N.
AU - Inada, T.
AU - Ozaki, N.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/6
Y1 - 2006/6
N2 - Several lines of evidence suggest that metabolic changes in the kynurenic acid (KYNA) pathway are related to the etiology of schizophrenia. The inhibitor of kynurenine 3-monooxygenase (KMO) is known to increase KYNA levels, and the KMO gene is located in the chromosome region associated with schizophrenia, 1q42-q44. Single-marker and haplotype analyses for 6-tag single nucleotide polymorphisms (SNPs) of KMO were performed (cases = 465, controls = 440). Significant association of rs2275163 with schizophrenia was observed by single-marker comparisons (P = 0.032) and haplotype analysis including this SNP (P = 0.0049). Significant association of rs2275163 and haplotype was not replicated using a second, independent set of samples (cases = 480, controls = 448) (P = 0.706 and P = 0.689, respectively). These results suggest that the KMO is unlikely to be related to the development of schizophrenia in Japanese.
AB - Several lines of evidence suggest that metabolic changes in the kynurenic acid (KYNA) pathway are related to the etiology of schizophrenia. The inhibitor of kynurenine 3-monooxygenase (KMO) is known to increase KYNA levels, and the KMO gene is located in the chromosome region associated with schizophrenia, 1q42-q44. Single-marker and haplotype analyses for 6-tag single nucleotide polymorphisms (SNPs) of KMO were performed (cases = 465, controls = 440). Significant association of rs2275163 with schizophrenia was observed by single-marker comparisons (P = 0.032) and haplotype analysis including this SNP (P = 0.0049). Significant association of rs2275163 and haplotype was not replicated using a second, independent set of samples (cases = 480, controls = 448) (P = 0.706 and P = 0.689, respectively). These results suggest that the KMO is unlikely to be related to the development of schizophrenia in Japanese.
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U2 - 10.1111/j.1601-183X.2006.00231.x
DO - 10.1111/j.1601-183X.2006.00231.x
M3 - Article
C2 - 16716206
AN - SCOPUS:33646925826
SN - 1601-1848
VL - 5
SP - 364
EP - 368
JO - Genes, Brain and Behavior
JF - Genes, Brain and Behavior
IS - 4
ER -