Abstract
Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH). A recent large-scale gene-association study in a Dutch population demonstrated that the PIK4CA gene was closely linked to schizophrenia [Jungerius et al. (2007); Mol Psychiatry]. Here, we conducted a case (N = 232)-control (N = 233) study of the PIK4CA gene on Japanese METH abusers, which can manifest severe psychosis similar to schizophrenia. The genotype and allelic distributions of all four single nucleotide polymorphisms (SNPs) did not differ significantly between the METH abusers and the controls. The comparisons based on the classification of the psychosis as transient or prolonged and on the presence or absence of spontaneous relapse revealed no significant distribution of the four SNPs compared to the controls. Furthermore, haplotype analyses showed almost the same frequencies between the METH abusers and the controls. The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population.
| Original language | English |
|---|---|
| Pages (from-to) | 233-238 |
| Number of pages | 6 |
| Journal | American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics |
| Volume | 150 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 05-03-2009 |
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All Science Journal Classification (ASJC) codes
- Genetics(clinical)
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
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Association study between the PIK4CA gene and methamphetamine use disorder in a japanese population. / Kanahara, Nobuhisa; Miyatake, Ryosuke; Sekine, Yoshimoto; Inada, Toshiya; Ozaki, Norio; Iwata, Nakao; Harano, Mutsuo; Komiyama, Tokutaro; Yamada, Mitsuhiko; Sora, Ichiro; Ujike, Hiroshi; Iyo, Masaomi; Hashimoto, Kenji.
In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 150, No. 2, 05.03.2009, p. 233-238.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association study between the PIK4CA gene and methamphetamine use disorder in a japanese population
AU - Kanahara, Nobuhisa
AU - Miyatake, Ryosuke
AU - Sekine, Yoshimoto
AU - Inada, Toshiya
AU - Ozaki, Norio
AU - Iwata, Nakao
AU - Harano, Mutsuo
AU - Komiyama, Tokutaro
AU - Yamada, Mitsuhiko
AU - Sora, Ichiro
AU - Ujike, Hiroshi
AU - Iyo, Masaomi
AU - Hashimoto, Kenji
PY - 2009/3/5
Y1 - 2009/3/5
N2 - Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH). A recent large-scale gene-association study in a Dutch population demonstrated that the PIK4CA gene was closely linked to schizophrenia [Jungerius et al. (2007); Mol Psychiatry]. Here, we conducted a case (N = 232)-control (N = 233) study of the PIK4CA gene on Japanese METH abusers, which can manifest severe psychosis similar to schizophrenia. The genotype and allelic distributions of all four single nucleotide polymorphisms (SNPs) did not differ significantly between the METH abusers and the controls. The comparisons based on the classification of the psychosis as transient or prolonged and on the presence or absence of spontaneous relapse revealed no significant distribution of the four SNPs compared to the controls. Furthermore, haplotype analyses showed almost the same frequencies between the METH abusers and the controls. The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population.
AB - Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH). A recent large-scale gene-association study in a Dutch population demonstrated that the PIK4CA gene was closely linked to schizophrenia [Jungerius et al. (2007); Mol Psychiatry]. Here, we conducted a case (N = 232)-control (N = 233) study of the PIK4CA gene on Japanese METH abusers, which can manifest severe psychosis similar to schizophrenia. The genotype and allelic distributions of all four single nucleotide polymorphisms (SNPs) did not differ significantly between the METH abusers and the controls. The comparisons based on the classification of the psychosis as transient or prolonged and on the presence or absence of spontaneous relapse revealed no significant distribution of the four SNPs compared to the controls. Furthermore, haplotype analyses showed almost the same frequencies between the METH abusers and the controls. The present study suggests that the PIK4CA gene does not play a significant role in the vulnerability to METH use disorder in the Japanese population.
UR - http://www.scopus.com/inward/record.url?scp=61449245571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61449245571&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.30797
DO - 10.1002/ajmg.b.30797
M3 - Article
C2 - 18521859
AN - SCOPUS:61449245571
VL - 150
SP - 233
EP - 238
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 2
ER -