@article{6a693a2881f24932a2adc9c4b269ba0f,
title = "Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population",
abstract = "B-cell CLL/lymphoma 9 (BCL9) is located within the schizophrenia (SCZ) suspected locus chr1q21.1. A recent study reported that a single nucleotide polyphormism (SNP) within BCL9 (rs583583) is associated with negative symptoms of Schizophrenia, as measured by the Positive and Negative Syndrome Scale (PANSS), in the Caucasian population. We therefore investigated genetic association of rs583583, and its effect on negative symptoms in the Japanese patients. For association analysis, we used a Japanese sample set comprising 1089 SCZ and 950 controls (CON). Analysis of the effect of rs586586 on negative symptoms as examined by PANSS was investigated using 280 SCZ. Furthermore, for analysis of cognitive performance, we investigated 90 SCZ and 51 CON using the Continuous Performance Test (CPT-IP) and the Wisconsin Card Sorting Test (WCST) Keio version. We did not detect association between rs583583 and SCZ. Furthermore, rs583583 was not associated with PANSS negative scores or with CPT-IT or WCST cognitive tests. Considering the results of our previous study, combined with the results of the current study of rs583583, we argue that BCL9 most likely does not harbor a common genetic variant that can increase the risk for SCZ in the Japanese population.",
author = "Hiroki Kimura and Satoshi Tanaka and Itaru Kushima and Takayoshi Koide and Masahiro Banno and Tsutomu Kikuchi and Yukako Nakamura and Tomoko Shiino and Akira Yoshimi and Tomoko Oya-Ito and Jingrui Xing and Chenyao Wang and Yuto Takasaki and Branko Aleksic and Takashi Okada and Masashi Ikeda and Toshiya Inada and Tetsuya Iidaka and Nakao Iwata and Norio Ozaki",
note = "Funding Information: We sincerely thank the patients and healthy volunteers for their participation in this study. We would like to express our gratitude to Yukari Mitsui, Mami Yoshida, and Hiromi Noma for their technical assistance, discussion, and contributions to creating and managing the database. This work was supported by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Ministry of Health, Labor and Welfare of Japan; a Grant-in-Aid for “Integrated research on neuropsychiatric disorders” carried out under the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED and the Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from Japan Agency for Medical Research and development, AMED; The Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes, Meijo University and the Core Research for Evolutional Science and Technology. The funding bodies had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Grant-in-Aid for Scientific Research on Innovative Areas, “Glial assembly: a new regulatory machinery of brain function and disorders”",
year = "2015",
month = oct,
day = "23",
doi = "10.1038/srep15705",
language = "English",
volume = "5",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}