Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population

Hiroki Kimura, Satoshi Tanaka, Itaru Kushima, Takayoshi Koide, Masahiro Banno, Tsutomu Kikuchi, Yukako Nakamura, Tomoko Shiino, Akira Yoshimi, Tomoko Oya-Ito, Jingrui Xing, Chenyao Wang, Yuto Takasaki, Branko Aleksic, Takashi Okada, Masashi Ikeda, Toshiya Inada, Tetsuya Iidaka, Nakao Iwata, Norio Ozaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

B-cell CLL/lymphoma 9 (BCL9) is located within the schizophrenia (SCZ) suspected locus chr1q21.1. A recent study reported that a single nucleotide polyphormism (SNP) within BCL9 (rs583583) is associated with negative symptoms of Schizophrenia, as measured by the Positive and Negative Syndrome Scale (PANSS), in the Caucasian population. We therefore investigated genetic association of rs583583, and its effect on negative symptoms in the Japanese patients. For association analysis, we used a Japanese sample set comprising 1089 SCZ and 950 controls (CON). Analysis of the effect of rs586586 on negative symptoms as examined by PANSS was investigated using 280 SCZ. Furthermore, for analysis of cognitive performance, we investigated 90 SCZ and 51 CON using the Continuous Performance Test (CPT-IP) and the Wisconsin Card Sorting Test (WCST) Keio version. We did not detect association between rs583583 and SCZ. Furthermore, rs583583 was not associated with PANSS negative scores or with CPT-IT or WCST cognitive tests. Considering the results of our previous study, combined with the results of the current study of rs583583, we argue that BCL9 most likely does not harbor a common genetic variant that can increase the risk for SCZ in the Japanese population.

Original languageEnglish
Article number15705
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 23-10-2015

Fingerprint

B-Cell Lymphoma
Schizophrenia
Population
Genes
Nucleotides

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kimura, Hiroki ; Tanaka, Satoshi ; Kushima, Itaru ; Koide, Takayoshi ; Banno, Masahiro ; Kikuchi, Tsutomu ; Nakamura, Yukako ; Shiino, Tomoko ; Yoshimi, Akira ; Oya-Ito, Tomoko ; Xing, Jingrui ; Wang, Chenyao ; Takasaki, Yuto ; Aleksic, Branko ; Okada, Takashi ; Ikeda, Masashi ; Inada, Toshiya ; Iidaka, Tetsuya ; Iwata, Nakao ; Ozaki, Norio. / Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population. In: Scientific Reports. 2015 ; Vol. 5.
@article{6a693a2881f24932a2adc9c4b269ba0f,
title = "Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population",
abstract = "B-cell CLL/lymphoma 9 (BCL9) is located within the schizophrenia (SCZ) suspected locus chr1q21.1. A recent study reported that a single nucleotide polyphormism (SNP) within BCL9 (rs583583) is associated with negative symptoms of Schizophrenia, as measured by the Positive and Negative Syndrome Scale (PANSS), in the Caucasian population. We therefore investigated genetic association of rs583583, and its effect on negative symptoms in the Japanese patients. For association analysis, we used a Japanese sample set comprising 1089 SCZ and 950 controls (CON). Analysis of the effect of rs586586 on negative symptoms as examined by PANSS was investigated using 280 SCZ. Furthermore, for analysis of cognitive performance, we investigated 90 SCZ and 51 CON using the Continuous Performance Test (CPT-IP) and the Wisconsin Card Sorting Test (WCST) Keio version. We did not detect association between rs583583 and SCZ. Furthermore, rs583583 was not associated with PANSS negative scores or with CPT-IT or WCST cognitive tests. Considering the results of our previous study, combined with the results of the current study of rs583583, we argue that BCL9 most likely does not harbor a common genetic variant that can increase the risk for SCZ in the Japanese population.",
author = "Hiroki Kimura and Satoshi Tanaka and Itaru Kushima and Takayoshi Koide and Masahiro Banno and Tsutomu Kikuchi and Yukako Nakamura and Tomoko Shiino and Akira Yoshimi and Tomoko Oya-Ito and Jingrui Xing and Chenyao Wang and Yuto Takasaki and Branko Aleksic and Takashi Okada and Masashi Ikeda and Toshiya Inada and Tetsuya Iidaka and Nakao Iwata and Norio Ozaki",
year = "2015",
month = "10",
day = "23",
doi = "10.1038/srep15705",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

Kimura, H, Tanaka, S, Kushima, I, Koide, T, Banno, M, Kikuchi, T, Nakamura, Y, Shiino, T, Yoshimi, A, Oya-Ito, T, Xing, J, Wang, C, Takasaki, Y, Aleksic, B, Okada, T, Ikeda, M, Inada, T, Iidaka, T, Iwata, N & Ozaki, N 2015, 'Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population', Scientific Reports, vol. 5, 15705. https://doi.org/10.1038/srep15705

Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population. / Kimura, Hiroki; Tanaka, Satoshi; Kushima, Itaru; Koide, Takayoshi; Banno, Masahiro; Kikuchi, Tsutomu; Nakamura, Yukako; Shiino, Tomoko; Yoshimi, Akira; Oya-Ito, Tomoko; Xing, Jingrui; Wang, Chenyao; Takasaki, Yuto; Aleksic, Branko; Okada, Takashi; Ikeda, Masashi; Inada, Toshiya; Iidaka, Tetsuya; Iwata, Nakao; Ozaki, Norio.

In: Scientific Reports, Vol. 5, 15705, 23.10.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association study of BCL9 gene polymorphism rs583583 with schizophrenia and negative symptoms in Japanese population

AU - Kimura, Hiroki

AU - Tanaka, Satoshi

AU - Kushima, Itaru

AU - Koide, Takayoshi

AU - Banno, Masahiro

AU - Kikuchi, Tsutomu

AU - Nakamura, Yukako

AU - Shiino, Tomoko

AU - Yoshimi, Akira

AU - Oya-Ito, Tomoko

AU - Xing, Jingrui

AU - Wang, Chenyao

AU - Takasaki, Yuto

AU - Aleksic, Branko

AU - Okada, Takashi

AU - Ikeda, Masashi

AU - Inada, Toshiya

AU - Iidaka, Tetsuya

AU - Iwata, Nakao

AU - Ozaki, Norio

PY - 2015/10/23

Y1 - 2015/10/23

N2 - B-cell CLL/lymphoma 9 (BCL9) is located within the schizophrenia (SCZ) suspected locus chr1q21.1. A recent study reported that a single nucleotide polyphormism (SNP) within BCL9 (rs583583) is associated with negative symptoms of Schizophrenia, as measured by the Positive and Negative Syndrome Scale (PANSS), in the Caucasian population. We therefore investigated genetic association of rs583583, and its effect on negative symptoms in the Japanese patients. For association analysis, we used a Japanese sample set comprising 1089 SCZ and 950 controls (CON). Analysis of the effect of rs586586 on negative symptoms as examined by PANSS was investigated using 280 SCZ. Furthermore, for analysis of cognitive performance, we investigated 90 SCZ and 51 CON using the Continuous Performance Test (CPT-IP) and the Wisconsin Card Sorting Test (WCST) Keio version. We did not detect association between rs583583 and SCZ. Furthermore, rs583583 was not associated with PANSS negative scores or with CPT-IT or WCST cognitive tests. Considering the results of our previous study, combined with the results of the current study of rs583583, we argue that BCL9 most likely does not harbor a common genetic variant that can increase the risk for SCZ in the Japanese population.

AB - B-cell CLL/lymphoma 9 (BCL9) is located within the schizophrenia (SCZ) suspected locus chr1q21.1. A recent study reported that a single nucleotide polyphormism (SNP) within BCL9 (rs583583) is associated with negative symptoms of Schizophrenia, as measured by the Positive and Negative Syndrome Scale (PANSS), in the Caucasian population. We therefore investigated genetic association of rs583583, and its effect on negative symptoms in the Japanese patients. For association analysis, we used a Japanese sample set comprising 1089 SCZ and 950 controls (CON). Analysis of the effect of rs586586 on negative symptoms as examined by PANSS was investigated using 280 SCZ. Furthermore, for analysis of cognitive performance, we investigated 90 SCZ and 51 CON using the Continuous Performance Test (CPT-IP) and the Wisconsin Card Sorting Test (WCST) Keio version. We did not detect association between rs583583 and SCZ. Furthermore, rs583583 was not associated with PANSS negative scores or with CPT-IT or WCST cognitive tests. Considering the results of our previous study, combined with the results of the current study of rs583583, we argue that BCL9 most likely does not harbor a common genetic variant that can increase the risk for SCZ in the Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=84945291997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945291997&partnerID=8YFLogxK

U2 - 10.1038/srep15705

DO - 10.1038/srep15705

M3 - Article

C2 - 26494551

AN - SCOPUS:84945291997

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 15705

ER -