Abstract
Recently the clock genes have been reported to play some roles in neural transmitter systems, including the dopamine system, as well as to regulate circadian rhythms. Abnormalities in both of these mechanisms are thought to be involved in the pathophysiology of major mental illness such as schizophrenia and mood disorders including bipolar disorder (BP) and major depressive disorder (MDD). Recent genetic studies have reported that CLOCK, one of the clock genes, is associated with these psychiatric disorders. Therefore, we investigated the association between the six tagging SNPs in CLOCK and the risk of these psychiatric disorders in Japanese patients diagnosed with schizophrenia (733 patients), BP (149) and MDD (324), plus 795 Japanese controls. Only one association, with schizophrenia in females, was detected in the haplotype analysis (P = 0.0362). However, this significance did not remain after Bonferroni correction (P = 0.0724). No significant association was found with BP and MDD. In conclusion, we suggest that CLOCK may not play a major role in the pathophysiology of Japanese schizophrenia, BP and MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.
| Original language | English |
|---|---|
| Pages (from-to) | 293-297 |
| Number of pages | 5 |
| Journal | European Archives of Psychiatry and Clinical Neuroscience |
| Volume | 259 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 01-08-2009 |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry
- Pharmacology (medical)
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Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population. / Kishi, Taro; Kitajima, Tsuyoshi; Ikeda, Masashi; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Okochi, Tomo; Okumura, Takenori; Tsunoka, Tomoko; Inada, Toshiya; Ozaki, Norio; Iwata, Nakao.
In: European Archives of Psychiatry and Clinical Neuroscience, Vol. 259, No. 5, 01.08.2009, p. 293-297.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population
AU - Kishi, Taro
AU - Kitajima, Tsuyoshi
AU - Ikeda, Masashi
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Kawashima, Kunihiro
AU - Okochi, Tomo
AU - Okumura, Takenori
AU - Tsunoka, Tomoko
AU - Inada, Toshiya
AU - Ozaki, Norio
AU - Iwata, Nakao
PY - 2009/8/1
Y1 - 2009/8/1
N2 - Recently the clock genes have been reported to play some roles in neural transmitter systems, including the dopamine system, as well as to regulate circadian rhythms. Abnormalities in both of these mechanisms are thought to be involved in the pathophysiology of major mental illness such as schizophrenia and mood disorders including bipolar disorder (BP) and major depressive disorder (MDD). Recent genetic studies have reported that CLOCK, one of the clock genes, is associated with these psychiatric disorders. Therefore, we investigated the association between the six tagging SNPs in CLOCK and the risk of these psychiatric disorders in Japanese patients diagnosed with schizophrenia (733 patients), BP (149) and MDD (324), plus 795 Japanese controls. Only one association, with schizophrenia in females, was detected in the haplotype analysis (P = 0.0362). However, this significance did not remain after Bonferroni correction (P = 0.0724). No significant association was found with BP and MDD. In conclusion, we suggest that CLOCK may not play a major role in the pathophysiology of Japanese schizophrenia, BP and MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.
AB - Recently the clock genes have been reported to play some roles in neural transmitter systems, including the dopamine system, as well as to regulate circadian rhythms. Abnormalities in both of these mechanisms are thought to be involved in the pathophysiology of major mental illness such as schizophrenia and mood disorders including bipolar disorder (BP) and major depressive disorder (MDD). Recent genetic studies have reported that CLOCK, one of the clock genes, is associated with these psychiatric disorders. Therefore, we investigated the association between the six tagging SNPs in CLOCK and the risk of these psychiatric disorders in Japanese patients diagnosed with schizophrenia (733 patients), BP (149) and MDD (324), plus 795 Japanese controls. Only one association, with schizophrenia in females, was detected in the haplotype analysis (P = 0.0362). However, this significance did not remain after Bonferroni correction (P = 0.0724). No significant association was found with BP and MDD. In conclusion, we suggest that CLOCK may not play a major role in the pathophysiology of Japanese schizophrenia, BP and MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.
UR - http://www.scopus.com/inward/record.url?scp=67349233890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349233890&partnerID=8YFLogxK
U2 - 10.1007/s00406-009-0869-4
DO - 10.1007/s00406-009-0869-4
M3 - Article
C2 - 19224106
AN - SCOPUS:67349233890
VL - 259
SP - 293
EP - 297
JO - Archiv fur Psychiatrie und Nervenkrankheiten
JF - Archiv fur Psychiatrie und Nervenkrankheiten
SN - 0003-9373
IS - 5
ER -