Association study of susceptibility genes for late-onset Alzheimer's disease in the Japanese population

Tomoyuki Ohara, Toshiharu Ninomiya, Yoichiro Hirakawa, Kyota Ashikawa, Akira Monji, Yutaka Kiyohara, Shigenobu Kanba, Michiaki Kubo

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

APOE is an established susceptibility gene for late-onset Alzheimer's disease (LOAD). Recent genome-wide association studies have identified many additional susceptibility genes for LOAD in populations of European descent. However, there is little information on whether or not genetic variants in these genes are associated with other ethnicities. To investigate the association of seven genes identified by genome-wide association studies, we carried out a case-control study using 825 LOAD cases and 2934 controls in the Japanese population. For the APOE gene, APOE-ε4 carriers had a 4.54-fold higher risk than APOE-ε4 noncarriers after adjusting for age and sex (P=4.6×10-27). For other genes, the single-nucleotide polymorphism in the PICALM gene was significantly associated with LOAD (P=0.02, odds ratio=1.23). There was no significant interaction between PICALM and APOE-ε4 carrier status (P for interaction=0.68). Our data indicate that PICALM is also a susceptibility gene for LOAD in the Japanese population.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalPsychiatric Genetics
Volume22
Issue number6
DOIs
Publication statusPublished - 01-12-2012
Externally publishedYes

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Alzheimer Disease
Population
Genes
Genome-Wide Association Study
Single Nucleotide Polymorphism
Case-Control Studies
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Ohara, Tomoyuki ; Ninomiya, Toshiharu ; Hirakawa, Yoichiro ; Ashikawa, Kyota ; Monji, Akira ; Kiyohara, Yutaka ; Kanba, Shigenobu ; Kubo, Michiaki. / Association study of susceptibility genes for late-onset Alzheimer's disease in the Japanese population. In: Psychiatric Genetics. 2012 ; Vol. 22, No. 6. pp. 290-293.
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Ohara, T, Ninomiya, T, Hirakawa, Y, Ashikawa, K, Monji, A, Kiyohara, Y, Kanba, S & Kubo, M 2012, 'Association study of susceptibility genes for late-onset Alzheimer's disease in the Japanese population', Psychiatric Genetics, vol. 22, no. 6, pp. 290-293. https://doi.org/10.1097/YPG.0b013e3283586215

Association study of susceptibility genes for late-onset Alzheimer's disease in the Japanese population. / Ohara, Tomoyuki; Ninomiya, Toshiharu; Hirakawa, Yoichiro; Ashikawa, Kyota; Monji, Akira; Kiyohara, Yutaka; Kanba, Shigenobu; Kubo, Michiaki.

In: Psychiatric Genetics, Vol. 22, No. 6, 01.12.2012, p. 290-293.

Research output: Contribution to journalArticle

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