Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse

Y. Kinoshita; M. Ikeda; H. Ujike; T. Kitajima; Y. Yamanouchi; B. Aleksic; T. Kishi; K. Kawashima; T. Ohkouchi; N. Ozaki; T. Inada; M. Harano; T. Komiyama; T. Hori; M. Yamada; Y. Sekine; M. Iyo; I. Sora; N. Iwata

doi:10.1196/annals.1432.021

Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse

Y. Kinoshita, M. Ikeda, H. Ujike, T. Kitajima, Y. Yamanouchi, B. Aleksic, T. Kishi, K. Kawashima, T. Ohkouchi, N. Ozaki, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, M. Iyo, I. Sora, N. Iwata

visiting faculty

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Citations (Scopus)

Abstract

Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

Original language	English
Title of host publication	Drug Addiction
Subtitle of host publication	Research Frontiers and Treatment Advances
Publisher	Blackwell Publishing Inc.
Pages	57-62
Number of pages	6
ISBN (Print)	9781573317184
DOIs	https://doi.org/10.1196/annals.1432.021
Publication status	Published - 10-2008

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1139
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1196/annals.1432.021

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Kinoshita, Y., Ikeda, M., Ujike, H., Kitajima, T., Yamanouchi, Y., Aleksic, B., Kishi, T., Kawashima, K., Ohkouchi, T., Ozaki, N., Inada, T., Harano, M., Komiyama, T., Hori, T., Yamada, M., Sekine, Y., Iyo, M., Sora, I., & Iwata, N. (2008). Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. In Drug Addiction: Research Frontiers and Treatment Advances (pp. 57-62). (Annals of the New York Academy of Sciences; Vol. 1139). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1432.021

Kinoshita, Y. ; Ikeda, M. ; Ujike, H. et al. / Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population : A collaborative study by the Japanese genetics initiative for drug abuse. Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc., 2008. pp. 57-62 (Annals of the New York Academy of Sciences).

@inproceedings{118539b4f7ea4545be8468d2d371a8e9,

title = "Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse",

abstract = "Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.",

keywords = "Association study, Calcineurin, Methamphetamine psychosis, PPP3C, Polymorphism, Substance abuse",

author = "Y. Kinoshita and M. Ikeda and H. Ujike and T. Kitajima and Y. Yamanouchi and B. Aleksic and T. Kishi and K. Kawashima and T. Ohkouchi and N. Ozaki and T. Inada and M. Harano and T. Komiyama and T. Hori and M. Yamada and Y. Sekine and M. Iyo and I. Sora and N. Iwata",

year = "2008",

month = oct,

doi = "10.1196/annals.1432.021",

language = "English",

isbn = "9781573317184",

series = "Annals of the New York Academy of Sciences",

publisher = "Blackwell Publishing Inc.",

pages = "57--62",

booktitle = "Drug Addiction",

}

Kinoshita, Y, Ikeda, M, Ujike, H, Kitajima, T, Yamanouchi, Y, Aleksic, B, Kishi, T, Kawashima, K, Ohkouchi, T, Ozaki, N, Inada, T, Harano, M, Komiyama, T, Hori, T, Yamada, M, Sekine, Y, Iyo, M, Sora, I & Iwata, N 2008, Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. in Drug Addiction: Research Frontiers and Treatment Advances. Annals of the New York Academy of Sciences, vol. 1139, Blackwell Publishing Inc., pp. 57-62. https://doi.org/10.1196/annals.1432.021

Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. / Kinoshita, Y.; Ikeda, M.; Ujike, H. et al.
Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc., 2008. p. 57-62 (Annals of the New York Academy of Sciences; Vol. 1139).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population

T2 - A collaborative study by the Japanese genetics initiative for drug abuse

AU - Kinoshita, Y.

AU - Ikeda, M.

AU - Ujike, H.

AU - Kitajima, T.

AU - Yamanouchi, Y.

AU - Aleksic, B.

AU - Kishi, T.

AU - Kawashima, K.

AU - Ohkouchi, T.

AU - Ozaki, N.

AU - Inada, T.

AU - Harano, M.

AU - Komiyama, T.

AU - Hori, T.

AU - Yamada, M.

AU - Sekine, Y.

AU - Iyo, M.

AU - Sora, I.

AU - Iwata, N.

PY - 2008/10

Y1 - 2008/10

N2 - Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

AB - Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

KW - Association study

KW - Calcineurin

KW - Methamphetamine psychosis

KW - PPP3C

KW - Polymorphism

KW - Substance abuse

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UR - http://www.scopus.com/inward/citedby.url?scp=53549087813&partnerID=8YFLogxK

U2 - 10.1196/annals.1432.021

DO - 10.1196/annals.1432.021

M3 - Conference contribution

C2 - 18991849

AN - SCOPUS:53549087813

SN - 9781573317184

T3 - Annals of the New York Academy of Sciences

SP - 57

EP - 62

BT - Drug Addiction

PB - Blackwell Publishing Inc.

ER -

Kinoshita Y, Ikeda M, Ujike H, Kitajima T, Yamanouchi Y, Aleksic B et al. Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. In Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc. 2008. p. 57-62. (Annals of the New York Academy of Sciences). doi: 10.1196/annals.1432.021

Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse

Abstract

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UN SDGs

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