Abstract
Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.
| Original language | English |
|---|---|
| Title of host publication | Drug Addiction |
| Subtitle of host publication | Research Frontiers and Treatment Advances |
| Publisher | Blackwell Publishing Inc. |
| Pages | 57-62 |
| Number of pages | 6 |
| ISBN (Print) | 9781573317184 |
| DOIs | |
| Publication status | Published - 01-01-2008 |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1139 |
| ISSN (Print) | 0077-8923 |
| ISSN (Electronic) | 1749-6632 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
}
Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population : A collaborative study by the Japanese genetics initiative for drug abuse. / Kinoshita, Y.; Ikeda, Masashi; Ujike, H.; Kitajima, Tsuyoshi; Yamanouchi, Y.; Aleksic, B.; Kishi, T.; Kawashima, K.; Ohkouchi, T.; Ozaki, N.; Inada, T.; Harano, M.; Komiyama, T.; Hori, T.; Yamada, M.; Sekine, Y.; Iyo, M.; Sora, I.; Iwata, Nakao.
Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc., 2008. p. 57-62 (Annals of the New York Academy of Sciences; Vol. 1139).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population
T2 - A collaborative study by the Japanese genetics initiative for drug abuse
AU - Kinoshita, Y.
AU - Ikeda, Masashi
AU - Ujike, H.
AU - Kitajima, Tsuyoshi
AU - Yamanouchi, Y.
AU - Aleksic, B.
AU - Kishi, T.
AU - Kawashima, K.
AU - Ohkouchi, T.
AU - Ozaki, N.
AU - Inada, T.
AU - Harano, M.
AU - Komiyama, T.
AU - Hori, T.
AU - Yamada, M.
AU - Sekine, Y.
AU - Iyo, M.
AU - Sora, I.
AU - Iwata, Nakao
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.
AB - Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.
UR - http://www.scopus.com/inward/record.url?scp=53549087813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53549087813&partnerID=8YFLogxK
U2 - 10.1196/annals.1432.021
DO - 10.1196/annals.1432.021
M3 - Conference contribution
C2 - 18991849
AN - SCOPUS:53549087813
SN - 9781573317184
T3 - Annals of the New York Academy of Sciences
SP - 57
EP - 62
BT - Drug Addiction
PB - Blackwell Publishing Inc.
ER -