TY - GEN
T1 - Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population
T2 - A collaborative study by the Japanese genetics initiative for drug abuse
AU - Kinoshita, Y.
AU - Ikeda, M.
AU - Ujike, H.
AU - Kitajima, T.
AU - Yamanouchi, Y.
AU - Aleksic, B.
AU - Kishi, T.
AU - Kawashima, K.
AU - Ohkouchi, T.
AU - Ozaki, N.
AU - Inada, T.
AU - Harano, M.
AU - Komiyama, T.
AU - Hori, T.
AU - Yamada, M.
AU - Sekine, Y.
AU - Iyo, M.
AU - Sora, I.
AU - Iwata, N.
PY - 2008/10
Y1 - 2008/10
N2 - Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.
AB - Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.
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U2 - 10.1196/annals.1432.021
DO - 10.1196/annals.1432.021
M3 - Conference contribution
C2 - 18991849
AN - SCOPUS:53549087813
SN - 9781573317184
T3 - Annals of the New York Academy of Sciences
SP - 57
EP - 62
BT - Drug Addiction
PB - Blackwell Publishing Inc.
ER -