Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse

Y. Kinoshita, Masashi Ikeda, H. Ujike, Tsuyoshi Kitajima, Y. Yamanouchi, B. Aleksic, T. Kishi, K. Kawashima, T. Ohkouchi, N. Ozaki, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, M. Iyo, I. Sora, Nakao Iwata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

Original languageEnglish
Title of host publicationDrug Addiction
Subtitle of host publicationResearch Frontiers and Treatment Advances
PublisherBlackwell Publishing Inc.
Pages57-62
Number of pages6
ISBN (Print)9781573317184
DOIs
Publication statusPublished - 01-01-2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1139
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Methamphetamine
Calcineurin
Substance-Related Disorders
Schizophrenia
Genes
Pharmaceutical Preparations
Population
Single Nucleotide Polymorphism
Genetic Association Studies
Psychotic Disorders
Haplotypes
Case-Control Studies
Animals
Genetics
Gene
Abuse
Drugs
Tagging

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Kinoshita, Y., Ikeda, M., Ujike, H., Kitajima, T., Yamanouchi, Y., Aleksic, B., ... Iwata, N. (2008). Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. In Drug Addiction: Research Frontiers and Treatment Advances (pp. 57-62). (Annals of the New York Academy of Sciences; Vol. 1139). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1432.021
Kinoshita, Y. ; Ikeda, Masashi ; Ujike, H. ; Kitajima, Tsuyoshi ; Yamanouchi, Y. ; Aleksic, B. ; Kishi, T. ; Kawashima, K. ; Ohkouchi, T. ; Ozaki, N. ; Inada, T. ; Harano, M. ; Komiyama, T. ; Hori, T. ; Yamada, M. ; Sekine, Y. ; Iyo, M. ; Sora, I. ; Iwata, Nakao. / Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population : A collaborative study by the Japanese genetics initiative for drug abuse. Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc., 2008. pp. 57-62 (Annals of the New York Academy of Sciences).
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title = "Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse",
abstract = "Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.",
author = "Y. Kinoshita and Masashi Ikeda and H. Ujike and Tsuyoshi Kitajima and Y. Yamanouchi and B. Aleksic and T. Kishi and K. Kawashima and T. Ohkouchi and N. Ozaki and T. Inada and M. Harano and T. Komiyama and T. Hori and M. Yamada and Y. Sekine and M. Iyo and I. Sora and Nakao Iwata",
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Kinoshita, Y, Ikeda, M, Ujike, H, Kitajima, T, Yamanouchi, Y, Aleksic, B, Kishi, T, Kawashima, K, Ohkouchi, T, Ozaki, N, Inada, T, Harano, M, Komiyama, T, Hori, T, Yamada, M, Sekine, Y, Iyo, M, Sora, I & Iwata, N 2008, Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. in Drug Addiction: Research Frontiers and Treatment Advances. Annals of the New York Academy of Sciences, vol. 1139, Blackwell Publishing Inc., pp. 57-62. https://doi.org/10.1196/annals.1432.021

Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population : A collaborative study by the Japanese genetics initiative for drug abuse. / Kinoshita, Y.; Ikeda, Masashi; Ujike, H.; Kitajima, Tsuyoshi; Yamanouchi, Y.; Aleksic, B.; Kishi, T.; Kawashima, K.; Ohkouchi, T.; Ozaki, N.; Inada, T.; Harano, M.; Komiyama, T.; Hori, T.; Yamada, M.; Sekine, Y.; Iyo, M.; Sora, I.; Iwata, Nakao.

Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc., 2008. p. 57-62 (Annals of the New York Academy of Sciences; Vol. 1139).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population

T2 - A collaborative study by the Japanese genetics initiative for drug abuse

AU - Kinoshita, Y.

AU - Ikeda, Masashi

AU - Ujike, H.

AU - Kitajima, Tsuyoshi

AU - Yamanouchi, Y.

AU - Aleksic, B.

AU - Kishi, T.

AU - Kawashima, K.

AU - Ohkouchi, T.

AU - Ozaki, N.

AU - Inada, T.

AU - Harano, M.

AU - Komiyama, T.

AU - Hori, T.

AU - Yamada, M.

AU - Sekine, Y.

AU - Iyo, M.

AU - Sora, I.

AU - Iwata, Nakao

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

AB - Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

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U2 - 10.1196/annals.1432.021

DO - 10.1196/annals.1432.021

M3 - Conference contribution

C2 - 18991849

AN - SCOPUS:53549087813

SN - 9781573317184

T3 - Annals of the New York Academy of Sciences

SP - 57

EP - 62

BT - Drug Addiction

PB - Blackwell Publishing Inc.

ER -

Kinoshita Y, Ikeda M, Ujike H, Kitajima T, Yamanouchi Y, Aleksic B et al. Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. In Drug Addiction: Research Frontiers and Treatment Advances. Blackwell Publishing Inc. 2008. p. 57-62. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1432.021