Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse

Y. Kinoshita, M. Ikeda, H. Ujike, T. Kitajima, Y. Yamanouchi, B. Aleksic, T. Kishi, K. Kawashima, T. Ohkouchi, N. Ozaki, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, M. Iyo, I. Sora, N. Iwata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population.

Original languageEnglish
Title of host publicationDrug Addiction
Subtitle of host publicationResearch Frontiers and Treatment Advances
PublisherBlackwell Publishing Inc.
Pages57-62
Number of pages6
ISBN (Print)9781573317184
DOIs
Publication statusPublished - 10-2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1139
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Kinoshita, Y., Ikeda, M., Ujike, H., Kitajima, T., Yamanouchi, Y., Aleksic, B., Kishi, T., Kawashima, K., Ohkouchi, T., Ozaki, N., Inada, T., Harano, M., Komiyama, T., Hori, T., Yamada, M., Sekine, Y., Iyo, M., Sora, I., & Iwata, N. (2008). Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population: A collaborative study by the Japanese genetics initiative for drug abuse. In Drug Addiction: Research Frontiers and Treatment Advances (pp. 57-62). (Annals of the New York Academy of Sciences; Vol. 1139). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1432.021