Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders

R. Hashimoto, T. Suzuki, Nakao Iwata, Y. Yamanouchi, Tsuyoshi Kitajima, A. Kosuga, M. Tatsumi, N. Ozaki, K. Kamijima, H. Kunugi

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Abstract

Two research groups have recently reported a significant association between schizophrenia and genetic variants of Frizzled-3 (FZD3) gene. We examined a possible association in a Japanese sample of schizophrenia, bipolar disorder, unipolar depression and controls with four single nucleotide polymorphisms (SNPs), tested in previous reports. We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalJournal of Neural Transmission
Volume112
Issue number2
DOIs
Publication statusPublished - 01-02-2005

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hashimoto, R., Suzuki, T., Iwata, N., Yamanouchi, Y., Kitajima, T., Kosuga, A., Tatsumi, M., Ozaki, N., Kamijima, K., & Kunugi, H. (2005). Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. Journal of Neural Transmission, 112(2), 303-307. https://doi.org/10.1007/s00702-004-0264-2