Association study of the G72 gene with schizophrenia in a Japanese population

A multicenter study

Kazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, Tetsuhiko Yoshida, Hidetoshi Takahashi, Naomi Iike, Motoyuki Fukumoto, Hironori Takamura, Masao Iwase, Kouzin Kamino, Ryouhei Ishii, Hiroaki Kazui, Ryuji Sekiyama, Yuri Kitamura, Michiyo Azechi, Koji Ikezawa, Ryu Kurimoto, Eiichiro Kamagata, Hitoshi Tanimukai, Shinji Tagami & 16 others Takashi Morihara, Masayuki Ogasawara, Masayasu Okochi, Hiromasa Tokunaga, Shusuke Numata, Masashi Ikeda, Tohru Ohnuma, Shu ichi Ueno, Tomoko Fukunaga, Toshihisa Tanaka, Takashi Kudo, Heii Arai, Tetsuro Ohmori, Nakao Iwata, Norio Ozaki, Masatoshi Takeda

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA). The aim of this study is to investigate the association between G72 and schizophrenia in a Japanese population, using the largest sample size to date (1774 patients with schizophrenia and 2092 healthy controls). We examined eight single nucleotide polymorphisms (SNPs), which had been associated with schizophrenia in previous studies. We found nominal evidence for association of alleles, M22/rs778293, M23/rs3918342 and M24/rs1421292, and the genotype of M22/rs778293 with schizophrenia, although there was no association of allele or genotype in the other five SNPs. We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population.

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalSchizophrenia Research
Volume109
Issue number1-3
DOIs
Publication statusPublished - 01-04-2009

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Multicenter Studies
Schizophrenia
Population
Genes
D-Amino-Acid Oxidase
Single Nucleotide Polymorphism
Alleles
Genotype
Sample Size

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Ohi, K., Hashimoto, R., Yasuda, Y., Yoshida, T., Takahashi, H., Iike, N., ... Takeda, M. (2009). Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study. Schizophrenia Research, 109(1-3), 80-85. https://doi.org/10.1016/j.schres.2009.01.019
Ohi, Kazutaka ; Hashimoto, Ryota ; Yasuda, Yuka ; Yoshida, Tetsuhiko ; Takahashi, Hidetoshi ; Iike, Naomi ; Fukumoto, Motoyuki ; Takamura, Hironori ; Iwase, Masao ; Kamino, Kouzin ; Ishii, Ryouhei ; Kazui, Hiroaki ; Sekiyama, Ryuji ; Kitamura, Yuri ; Azechi, Michiyo ; Ikezawa, Koji ; Kurimoto, Ryu ; Kamagata, Eiichiro ; Tanimukai, Hitoshi ; Tagami, Shinji ; Morihara, Takashi ; Ogasawara, Masayuki ; Okochi, Masayasu ; Tokunaga, Hiromasa ; Numata, Shusuke ; Ikeda, Masashi ; Ohnuma, Tohru ; Ueno, Shu ichi ; Fukunaga, Tomoko ; Tanaka, Toshihisa ; Kudo, Takashi ; Arai, Heii ; Ohmori, Tetsuro ; Iwata, Nakao ; Ozaki, Norio ; Takeda, Masatoshi. / Association study of the G72 gene with schizophrenia in a Japanese population : A multicenter study. In: Schizophrenia Research. 2009 ; Vol. 109, No. 1-3. pp. 80-85.
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Ohi, K, Hashimoto, R, Yasuda, Y, Yoshida, T, Takahashi, H, Iike, N, Fukumoto, M, Takamura, H, Iwase, M, Kamino, K, Ishii, R, Kazui, H, Sekiyama, R, Kitamura, Y, Azechi, M, Ikezawa, K, Kurimoto, R, Kamagata, E, Tanimukai, H, Tagami, S, Morihara, T, Ogasawara, M, Okochi, M, Tokunaga, H, Numata, S, Ikeda, M, Ohnuma, T, Ueno, SI, Fukunaga, T, Tanaka, T, Kudo, T, Arai, H, Ohmori, T, Iwata, N, Ozaki, N & Takeda, M 2009, 'Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study', Schizophrenia Research, vol. 109, no. 1-3, pp. 80-85. https://doi.org/10.1016/j.schres.2009.01.019

Association study of the G72 gene with schizophrenia in a Japanese population : A multicenter study. / Ohi, Kazutaka; Hashimoto, Ryota; Yasuda, Yuka; Yoshida, Tetsuhiko; Takahashi, Hidetoshi; Iike, Naomi; Fukumoto, Motoyuki; Takamura, Hironori; Iwase, Masao; Kamino, Kouzin; Ishii, Ryouhei; Kazui, Hiroaki; Sekiyama, Ryuji; Kitamura, Yuri; Azechi, Michiyo; Ikezawa, Koji; Kurimoto, Ryu; Kamagata, Eiichiro; Tanimukai, Hitoshi; Tagami, Shinji; Morihara, Takashi; Ogasawara, Masayuki; Okochi, Masayasu; Tokunaga, Hiromasa; Numata, Shusuke; Ikeda, Masashi; Ohnuma, Tohru; Ueno, Shu ichi; Fukunaga, Tomoko; Tanaka, Toshihisa; Kudo, Takashi; Arai, Heii; Ohmori, Tetsuro; Iwata, Nakao; Ozaki, Norio; Takeda, Masatoshi.

In: Schizophrenia Research, Vol. 109, No. 1-3, 01.04.2009, p. 80-85.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association study of the G72 gene with schizophrenia in a Japanese population

T2 - A multicenter study

AU - Ohi, Kazutaka

AU - Hashimoto, Ryota

AU - Yasuda, Yuka

AU - Yoshida, Tetsuhiko

AU - Takahashi, Hidetoshi

AU - Iike, Naomi

AU - Fukumoto, Motoyuki

AU - Takamura, Hironori

AU - Iwase, Masao

AU - Kamino, Kouzin

AU - Ishii, Ryouhei

AU - Kazui, Hiroaki

AU - Sekiyama, Ryuji

AU - Kitamura, Yuri

AU - Azechi, Michiyo

AU - Ikezawa, Koji

AU - Kurimoto, Ryu

AU - Kamagata, Eiichiro

AU - Tanimukai, Hitoshi

AU - Tagami, Shinji

AU - Morihara, Takashi

AU - Ogasawara, Masayuki

AU - Okochi, Masayasu

AU - Tokunaga, Hiromasa

AU - Numata, Shusuke

AU - Ikeda, Masashi

AU - Ohnuma, Tohru

AU - Ueno, Shu ichi

AU - Fukunaga, Tomoko

AU - Tanaka, Toshihisa

AU - Kudo, Takashi

AU - Arai, Heii

AU - Ohmori, Tetsuro

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Takeda, Masatoshi

PY - 2009/4/1

Y1 - 2009/4/1

N2 - G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA). The aim of this study is to investigate the association between G72 and schizophrenia in a Japanese population, using the largest sample size to date (1774 patients with schizophrenia and 2092 healthy controls). We examined eight single nucleotide polymorphisms (SNPs), which had been associated with schizophrenia in previous studies. We found nominal evidence for association of alleles, M22/rs778293, M23/rs3918342 and M24/rs1421292, and the genotype of M22/rs778293 with schizophrenia, although there was no association of allele or genotype in the other five SNPs. We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population.

AB - G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA). The aim of this study is to investigate the association between G72 and schizophrenia in a Japanese population, using the largest sample size to date (1774 patients with schizophrenia and 2092 healthy controls). We examined eight single nucleotide polymorphisms (SNPs), which had been associated with schizophrenia in previous studies. We found nominal evidence for association of alleles, M22/rs778293, M23/rs3918342 and M24/rs1421292, and the genotype of M22/rs778293 with schizophrenia, although there was no association of allele or genotype in the other five SNPs. We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population.

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DO - 10.1016/j.schres.2009.01.019

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JO - Schizophrenia Research

JF - Schizophrenia Research

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