Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population

Tomonaga Matsushita, Junji Umeno, Yoichiro Hirakawa, Koji Yonemoto, Kyota Ashikawa, Hanae Amitani, Toshiharu Ninomiya, Jun Hata, Yasufumi Doi, Takanari Kitazono, Mitsuo Iida, Yusuke Nakamura, Yutaka Kiyohara, Michiaki Kubo

Research output: Contribution to journalArticle

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Abstract

Recent genome-wide association study using four prospective population-based cohorts identified two single-nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579, to be significantly associated with the incidence of atherothrombotic stroke. To examine the association of these SNPs with atherothrombotic stroke in the Japanese population, we carried out a case-control association study using a total of 3784 cases and 3102 controls. We also examined the effect of these SNPs on the subtypes of ischemic stroke. Association analysis was carried out using logistic regression model after adjustment of age, sex and cardiovascular risk factors. Rs12425791 was significantly associated with atherothrombotic stroke (P=0.0084, odds ratio (OR)=1.15). When we analyzed effects of rs12425791 on ischemic stroke subtypes, rs12425791 was significantly associated with both small-artery occlusion (P=0.015, OR=1.15) and large-artery atherosclerosis (P=0.024, OR=1.19). Rs11833579 showed no association with atherothrombotic stroke or its subtypes in our population. Our data suggest that rs12425791 on chromosome 12p13 is a genetic marker for atherothrombotic stroke in multiethnic population.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalJournal of Human Genetics
Volume55
Issue number7
DOIs
Publication statusPublished - 01-07-2010

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Chromosomes
Stroke
Population
Single Nucleotide Polymorphism
Odds Ratio
Arteries
Logistic Models
Genome-Wide Association Study
Genetic Markers
Case-Control Studies
Atherosclerosis
Incidence

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Matsushita, Tomonaga ; Umeno, Junji ; Hirakawa, Yoichiro ; Yonemoto, Koji ; Ashikawa, Kyota ; Amitani, Hanae ; Ninomiya, Toshiharu ; Hata, Jun ; Doi, Yasufumi ; Kitazono, Takanari ; Iida, Mitsuo ; Nakamura, Yusuke ; Kiyohara, Yutaka ; Kubo, Michiaki. / Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population. In: Journal of Human Genetics. 2010 ; Vol. 55, No. 7. pp. 473-476.
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abstract = "Recent genome-wide association study using four prospective population-based cohorts identified two single-nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579, to be significantly associated with the incidence of atherothrombotic stroke. To examine the association of these SNPs with atherothrombotic stroke in the Japanese population, we carried out a case-control association study using a total of 3784 cases and 3102 controls. We also examined the effect of these SNPs on the subtypes of ischemic stroke. Association analysis was carried out using logistic regression model after adjustment of age, sex and cardiovascular risk factors. Rs12425791 was significantly associated with atherothrombotic stroke (P=0.0084, odds ratio (OR)=1.15). When we analyzed effects of rs12425791 on ischemic stroke subtypes, rs12425791 was significantly associated with both small-artery occlusion (P=0.015, OR=1.15) and large-artery atherosclerosis (P=0.024, OR=1.19). Rs11833579 showed no association with atherothrombotic stroke or its subtypes in our population. Our data suggest that rs12425791 on chromosome 12p13 is a genetic marker for atherothrombotic stroke in multiethnic population.",
author = "Tomonaga Matsushita and Junji Umeno and Yoichiro Hirakawa and Koji Yonemoto and Kyota Ashikawa and Hanae Amitani and Toshiharu Ninomiya and Jun Hata and Yasufumi Doi and Takanari Kitazono and Mitsuo Iida and Yusuke Nakamura and Yutaka Kiyohara and Michiaki Kubo",
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Matsushita, T, Umeno, J, Hirakawa, Y, Yonemoto, K, Ashikawa, K, Amitani, H, Ninomiya, T, Hata, J, Doi, Y, Kitazono, T, Iida, M, Nakamura, Y, Kiyohara, Y & Kubo, M 2010, 'Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population', Journal of Human Genetics, vol. 55, no. 7, pp. 473-476. https://doi.org/10.1038/jhg.2010.45

Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population. / Matsushita, Tomonaga; Umeno, Junji; Hirakawa, Yoichiro; Yonemoto, Koji; Ashikawa, Kyota; Amitani, Hanae; Ninomiya, Toshiharu; Hata, Jun; Doi, Yasufumi; Kitazono, Takanari; Iida, Mitsuo; Nakamura, Yusuke; Kiyohara, Yutaka; Kubo, Michiaki.

In: Journal of Human Genetics, Vol. 55, No. 7, 01.07.2010, p. 473-476.

Research output: Contribution to journalArticle

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T1 - Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population

AU - Matsushita, Tomonaga

AU - Umeno, Junji

AU - Hirakawa, Yoichiro

AU - Yonemoto, Koji

AU - Ashikawa, Kyota

AU - Amitani, Hanae

AU - Ninomiya, Toshiharu

AU - Hata, Jun

AU - Doi, Yasufumi

AU - Kitazono, Takanari

AU - Iida, Mitsuo

AU - Nakamura, Yusuke

AU - Kiyohara, Yutaka

AU - Kubo, Michiaki

PY - 2010/7/1

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N2 - Recent genome-wide association study using four prospective population-based cohorts identified two single-nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579, to be significantly associated with the incidence of atherothrombotic stroke. To examine the association of these SNPs with atherothrombotic stroke in the Japanese population, we carried out a case-control association study using a total of 3784 cases and 3102 controls. We also examined the effect of these SNPs on the subtypes of ischemic stroke. Association analysis was carried out using logistic regression model after adjustment of age, sex and cardiovascular risk factors. Rs12425791 was significantly associated with atherothrombotic stroke (P=0.0084, odds ratio (OR)=1.15). When we analyzed effects of rs12425791 on ischemic stroke subtypes, rs12425791 was significantly associated with both small-artery occlusion (P=0.015, OR=1.15) and large-artery atherosclerosis (P=0.024, OR=1.19). Rs11833579 showed no association with atherothrombotic stroke or its subtypes in our population. Our data suggest that rs12425791 on chromosome 12p13 is a genetic marker for atherothrombotic stroke in multiethnic population.

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