Abstract
Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.
Original language | English |
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Title of host publication | Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity |
Subtitle of host publication | Cocaine, GHB, and Substituted Amphetamines |
Pages | 116-124 |
Number of pages | 9 |
Volume | 1074 |
DOIs | |
Publication status | Published - 08-2006 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Neuroscience
- General Biochemistry,Genetics and Molecular Biology
- History and Philosophy of Science