Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence

A. Nomura, Hiroshi Ujike, Y. Tanaka, M. Kishimoto, K. Otani, Y. Morita, A. Morio, M. Harano, T. Inada, M. Yamada, T. Komiyama, T. Hori, Y. Sekine, N. Iwata, I. Sora, M. Iyo, N. Ozaki, S. Kuroda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.

Original languageEnglish
Title of host publicationCellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity
Subtitle of host publicationCocaine, GHB, and Substituted Amphetamines
PublisherBlackwell Publishing Inc.
Pages116-124
Number of pages9
ISBN (Print)1573316296, 9781573316293
DOIs
Publication statusPublished - 01-01-2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1074
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Methamphetamine
Tumor Necrosis Factor-alpha
Genes
Gene
Tumor Necrosis Factor Receptors
Genetic Polymorphisms
Polymorphism
Genetic Promoter Regions
Haplotypes
Exons
Brain
Alleles
Cytokines
Phenotype
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Nomura, A., Ujike, H., Tanaka, Y., Kishimoto, M., Otani, K., Morita, Y., ... Kuroda, S. (2006). Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence. In Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines (pp. 116-124). (Annals of the New York Academy of Sciences; Vol. 1074). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1369.011
Nomura, A. ; Ujike, Hiroshi ; Tanaka, Y. ; Kishimoto, M. ; Otani, K. ; Morita, Y. ; Morio, A. ; Harano, M. ; Inada, T. ; Yamada, M. ; Komiyama, T. ; Hori, T. ; Sekine, Y. ; Iwata, N. ; Sora, I. ; Iyo, M. ; Ozaki, N. ; Kuroda, S. / Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence. Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines. Blackwell Publishing Inc., 2006. pp. 116-124 (Annals of the New York Academy of Sciences).
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title = "Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence",
abstract = "Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.",
author = "A. Nomura and Hiroshi Ujike and Y. Tanaka and M. Kishimoto and K. Otani and Y. Morita and A. Morio and M. Harano and T. Inada and M. Yamada and T. Komiyama and T. Hori and Y. Sekine and N. Iwata and I. Sora and M. Iyo and N. Ozaki and S. Kuroda",
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Nomura, A, Ujike, H, Tanaka, Y, Kishimoto, M, Otani, K, Morita, Y, Morio, A, Harano, M, Inada, T, Yamada, M, Komiyama, T, Hori, T, Sekine, Y, Iwata, N, Sora, I, Iyo, M, Ozaki, N & Kuroda, S 2006, Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence. in Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines. Annals of the New York Academy of Sciences, vol. 1074, Blackwell Publishing Inc., pp. 116-124. https://doi.org/10.1196/annals.1369.011

Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence. / Nomura, A.; Ujike, Hiroshi; Tanaka, Y.; Kishimoto, M.; Otani, K.; Morita, Y.; Morio, A.; Harano, M.; Inada, T.; Yamada, M.; Komiyama, T.; Hori, T.; Sekine, Y.; Iwata, N.; Sora, I.; Iyo, M.; Ozaki, N.; Kuroda, S.

Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines. Blackwell Publishing Inc., 2006. p. 116-124 (Annals of the New York Academy of Sciences; Vol. 1074).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence

AU - Nomura, A.

AU - Ujike, Hiroshi

AU - Tanaka, Y.

AU - Kishimoto, M.

AU - Otani, K.

AU - Morita, Y.

AU - Morio, A.

AU - Harano, M.

AU - Inada, T.

AU - Yamada, M.

AU - Komiyama, T.

AU - Hori, T.

AU - Sekine, Y.

AU - Iwata, N.

AU - Sora, I.

AU - Iyo, M.

AU - Ozaki, N.

AU - Kuroda, S.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.

AB - Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.

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U2 - 10.1196/annals.1369.011

DO - 10.1196/annals.1369.011

M3 - Conference contribution

SN - 1573316296

SN - 9781573316293

T3 - Annals of the New York Academy of Sciences

SP - 116

EP - 124

BT - Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity

PB - Blackwell Publishing Inc.

ER -

Nomura A, Ujike H, Tanaka Y, Kishimoto M, Otani K, Morita Y et al. Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence. In Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines. Blackwell Publishing Inc. 2006. p. 116-124. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1369.011