Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence

A. Nomura; Hiroshi Ujike; Y. Tanaka; M. Kishimoto; K. Otani; Y. Morita; A. Morio; M. Harano; T. Inada; M. Yamada; T. Komiyama; T. Hori; Y. Sekine; N. Iwata; I. Sora; M. Iyo; N. Ozaki; S. Kuroda

doi:10.1196/annals.1369.011

Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence

A. Nomura, Hiroshi Ujike, Y. Tanaka, M. Kishimoto, K. Otani, Y. Morita, A. Morio, M. Harano, T. Inada, M. Yamada, T. Komiyama, T. Hori, Y. Sekine, N. Iwata, I. Sora, M. Iyo, N. Ozaki, S. Kuroda

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Citations (Scopus)

Abstract

Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.

Original language	English
Title of host publication	Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity
Subtitle of host publication	Cocaine, GHB, and Substituted Amphetamines
Pages	116-124
Number of pages	9
Volume	1074
DOIs	https://doi.org/10.1196/annals.1369.011
Publication status	Published - 08-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

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Nomura, A., Ujike, H., Tanaka, Y., Kishimoto, M., Otani, K., Morita, Y., Morio, A., Harano, M., Inada, T., Yamada, M., Komiyama, T., Hori, T., Sekine, Y., Iwata, N., Sora, I., Iyo, M., Ozaki, N., & Kuroda, S. (2006). Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence. In Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines (Vol. 1074, pp. 116-124) https://doi.org/10.1196/annals.1369.011

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title = "Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence",

abstract = "Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.",

keywords = "Case-control association study, Substance dependence, Tumor necrosis factor-α",

author = "A. Nomura and Hiroshi Ujike and Y. Tanaka and M. Kishimoto and K. Otani and Y. Morita and A. Morio and M. Harano and T. Inada and M. Yamada and T. Komiyama and T. Hori and Y. Sekine and N. Iwata and I. Sora and M. Iyo and N. Ozaki and S. Kuroda",

year = "2006",

month = aug,

doi = "10.1196/annals.1369.011",

language = "English",

isbn = "1573316296",

volume = "1074",

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booktitle = "Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity",

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Nomura, A, Ujike, H, Tanaka, Y, Kishimoto, M, Otani, K, Morita, Y, Morio, A, Harano, M, Inada, T, Yamada, M, Komiyama, T, Hori, T, Sekine, Y, Iwata, N, Sora, I, Iyo, M, Ozaki, N & Kuroda, S 2006, Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence. in Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines. vol. 1074, pp. 116-124. https://doi.org/10.1196/annals.1369.011

Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence. / Nomura, A.; Ujike, Hiroshi; Tanaka, Y. et al.
Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, GHB, and Substituted Amphetamines. Vol. 1074 2006. p. 116-124.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence

AU - Nomura, A.

AU - Ujike, Hiroshi

AU - Tanaka, Y.

AU - Kishimoto, M.

AU - Otani, K.

AU - Morita, Y.

AU - Morio, A.

AU - Harano, M.

AU - Inada, T.

AU - Yamada, M.

AU - Komiyama, T.

AU - Hori, T.

AU - Sekine, Y.

AU - Iwata, N.

AU - Sora, I.

AU - Iyo, M.

AU - Ozaki, N.

AU - Kuroda, S.

PY - 2006/8

Y1 - 2006/8

N2 - Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.

AB - Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence (n = 185) and healthy controls (n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.

KW - Case-control association study

KW - Substance dependence

KW - Tumor necrosis factor-α

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U2 - 10.1196/annals.1369.011

DO - 10.1196/annals.1369.011

M3 - Conference contribution

C2 - 17105909

AN - SCOPUS:33749573646

SN - 1573316296

SN - 9781573316293

VL - 1074

SP - 116

EP - 124

BT - Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity

ER -

Association study of the tumor necrosis factor-α gene and its 1A receptor gene with methamphetamine dependence

Abstract

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