Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population

Itaru Kushima, Branko Aleksic, Yoshihito Ito, Yukako Nakamura, Kazuhiko Nakamura, Norio Mori, Mitsuru Kikuchi, Toshiya Inada, Hiroshi Kunugi, Shinichiro Nanko, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Michio Suzuki, Nakao Iwata, Norio Ozaki

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Recently, ubiquitin-specific peptidase 46 (Usp46) has been identified as a quantitative trait gene responsible for immobility in the tail suspension test and forced swimming test in mice. Mice with 3-bp deletion in Usp46 exhibited loss of behavioral despair under inescapable stresses in addition to abnormalities in circadian behavioral rhythms and the GABAergic system. Considering the face and construct validity as an animal model for bipolar disorder, we explored an association of USP46 and bipolar disorder in a Japanese population. We also examined an association of USP46 and schizophrenia. We found nominal evidence for an association of rs12646800 and schizophrenia. This association was not significant after correction for multiple testing. No significant association was detected for bipolar disorder. In conclusion, our data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalJournal of Human Genetics
Volume55
Issue number3
DOIs
Publication statusPublished - 03-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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