Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population

Itaru Kushima, Branko Aleksic, Yoshihito Ito, Yukako Nakamura, Kazuhiko Nakamura, Norio Mori, Mitsuru Kikuchi, Toshiya Inada, Hiroshi Kunugi, Shinichiro Nanko, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Michio Suzuki, Nakao Iwata, Norio Ozaki

Research output: Contribution to journalArticle

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Abstract

Recently, ubiquitin-specific peptidase 46 (Usp46) has been identified as a quantitative trait gene responsible for immobility in the tail suspension test and forced swimming test in mice. Mice with 3-bp deletion in Usp46 exhibited loss of behavioral despair under inescapable stresses in addition to abnormalities in circadian behavioral rhythms and the GABAergic system. Considering the face and construct validity as an animal model for bipolar disorder, we explored an association of USP46 and bipolar disorder in a Japanese population. We also examined an association of USP46 and schizophrenia. We found nominal evidence for an association of rs12646800 and schizophrenia. This association was not significant after correction for multiple testing. No significant association was detected for bipolar disorder. In conclusion, our data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalJournal of Human Genetics
Volume55
Issue number3
DOIs
Publication statusPublished - 01-01-2010

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Ubiquitin
Bipolar Disorder
Schizophrenia
Peptide Hydrolases
Population
Hindlimb Suspension
Genetic Predisposition to Disease
Circadian Rhythm
Reproducibility of Results
Animal Models
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Kushima, Itaru ; Aleksic, Branko ; Ito, Yoshihito ; Nakamura, Yukako ; Nakamura, Kazuhiko ; Mori, Norio ; Kikuchi, Mitsuru ; Inada, Toshiya ; Kunugi, Hiroshi ; Nanko, Shinichiro ; Kato, Tadafumi ; Yoshikawa, Takeo ; Ujike, Hiroshi ; Suzuki, Michio ; Iwata, Nakao ; Ozaki, Norio. / Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population. In: Journal of Human Genetics. 2010 ; Vol. 55, No. 3. pp. 133-136.
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abstract = "Recently, ubiquitin-specific peptidase 46 (Usp46) has been identified as a quantitative trait gene responsible for immobility in the tail suspension test and forced swimming test in mice. Mice with 3-bp deletion in Usp46 exhibited loss of behavioral despair under inescapable stresses in addition to abnormalities in circadian behavioral rhythms and the GABAergic system. Considering the face and construct validity as an animal model for bipolar disorder, we explored an association of USP46 and bipolar disorder in a Japanese population. We also examined an association of USP46 and schizophrenia. We found nominal evidence for an association of rs12646800 and schizophrenia. This association was not significant after correction for multiple testing. No significant association was detected for bipolar disorder. In conclusion, our data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46.",
author = "Itaru Kushima and Branko Aleksic and Yoshihito Ito and Yukako Nakamura and Kazuhiko Nakamura and Norio Mori and Mitsuru Kikuchi and Toshiya Inada and Hiroshi Kunugi and Shinichiro Nanko and Tadafumi Kato and Takeo Yoshikawa and Hiroshi Ujike and Michio Suzuki and Nakao Iwata and Norio Ozaki",
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Kushima, I, Aleksic, B, Ito, Y, Nakamura, Y, Nakamura, K, Mori, N, Kikuchi, M, Inada, T, Kunugi, H, Nanko, S, Kato, T, Yoshikawa, T, Ujike, H, Suzuki, M, Iwata, N & Ozaki, N 2010, 'Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population', Journal of Human Genetics, vol. 55, no. 3, pp. 133-136. https://doi.org/10.1038/jhg.2009.139

Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population. / Kushima, Itaru; Aleksic, Branko; Ito, Yoshihito; Nakamura, Yukako; Nakamura, Kazuhiko; Mori, Norio; Kikuchi, Mitsuru; Inada, Toshiya; Kunugi, Hiroshi; Nanko, Shinichiro; Kato, Tadafumi; Yoshikawa, Takeo; Ujike, Hiroshi; Suzuki, Michio; Iwata, Nakao; Ozaki, Norio.

In: Journal of Human Genetics, Vol. 55, No. 3, 01.01.2010, p. 133-136.

Research output: Contribution to journalArticle

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T1 - Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population

AU - Kushima, Itaru

AU - Aleksic, Branko

AU - Ito, Yoshihito

AU - Nakamura, Yukako

AU - Nakamura, Kazuhiko

AU - Mori, Norio

AU - Kikuchi, Mitsuru

AU - Inada, Toshiya

AU - Kunugi, Hiroshi

AU - Nanko, Shinichiro

AU - Kato, Tadafumi

AU - Yoshikawa, Takeo

AU - Ujike, Hiroshi

AU - Suzuki, Michio

AU - Iwata, Nakao

AU - Ozaki, Norio

PY - 2010/1/1

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