Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population

Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the hOGG1 genotype and body mass index (BMI) and fasting blood glucose (FBG) levels. Methods: Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40-69 years. The hOGG1 polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables. Results: The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (>27.5 kg/m2). However, the impact of genotype decreased and significance disappeared after adjusting for the study area. Conclusions: The present results suggest that the study area being inside Japan confounds the association between hOGG1 genotype and obesity.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalJournal of epidemiology
Volume24
Issue number5
DOIs
Publication statusPublished - 01-01-2014

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Fasting
Body Mass Index
Genotype
Glucose
Blood Glucose
Population
Japan
Obesity
Cholesterol
Confounding Factors (Epidemiology)
Multiplex Polymerase Chain Reaction
Genetic Polymorphisms
Energy Intake
Type 2 Diabetes Mellitus
Insulin Resistance
Linear Models
Cohort Studies
Cross-Sectional Studies
Logistic Models
Smoking

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group. / Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population. In: Journal of epidemiology. 2014 ; Vol. 24, No. 5. pp. 379-384.
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title = "Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population",
abstract = "Background: Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the hOGG1 genotype and body mass index (BMI) and fasting blood glucose (FBG) levels. Methods: Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40-69 years. The hOGG1 polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables. Results: The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (>27.5 kg/m2). However, the impact of genotype decreased and significance disappeared after adjusting for the study area. Conclusions: The present results suggest that the study area being inside Japan confounds the association between hOGG1 genotype and obesity.",
author = "{Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group} and Megumi Hara and Kazuyo Nakamura and Hinako Nanri and Yuichiro Nishida and Asahi Hishida and Sayo Kawai and Nobuyuki Hamajima and Yoshikuni Kita and Sadao Suzuki and Mantjoro, {Eva Mariane} and Keizo Ohnaka and Hirokazu Uemura and Daisuke Matsui and Isao Oze and Haruo Mikami and Michiaki Kubo and Michiaki Kubo",
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Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population. / Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.

In: Journal of epidemiology, Vol. 24, No. 5, 01.01.2014, p. 379-384.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population

AU - Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group

AU - Hara, Megumi

AU - Nakamura, Kazuyo

AU - Nanri, Hinako

AU - Nishida, Yuichiro

AU - Hishida, Asahi

AU - Kawai, Sayo

AU - Hamajima, Nobuyuki

AU - Kita, Yoshikuni

AU - Suzuki, Sadao

AU - Mantjoro, Eva Mariane

AU - Ohnaka, Keizo

AU - Uemura, Hirokazu

AU - Matsui, Daisuke

AU - Oze, Isao

AU - Mikami, Haruo

AU - Kubo, Michiaki

AU - Kubo, Michiaki

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the hOGG1 genotype and body mass index (BMI) and fasting blood glucose (FBG) levels. Methods: Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40-69 years. The hOGG1 polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables. Results: The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (>27.5 kg/m2). However, the impact of genotype decreased and significance disappeared after adjusting for the study area. Conclusions: The present results suggest that the study area being inside Japan confounds the association between hOGG1 genotype and obesity.

AB - Background: Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the hOGG1 genotype and body mass index (BMI) and fasting blood glucose (FBG) levels. Methods: Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40-69 years. The hOGG1 polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables. Results: The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (>27.5 kg/m2). However, the impact of genotype decreased and significance disappeared after adjusting for the study area. Conclusions: The present results suggest that the study area being inside Japan confounds the association between hOGG1 genotype and obesity.

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DO - 10.2188/jea.JE20140002

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