Associations of Food and Nutrient Intakes with Serum IGF-I, IGF-II, IGFBP-3, TGF-β1, Total SOD Activity and sfas Levels among Middle-aged Japanese

The JACC Study

Koutatsu Maruyama, Hiroyasu Iso, Yoshinori Ito, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi, Akiko Tamakoshi, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito Tanabe, Koji Tamakoshi, Kenji Wakai & 16 others Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Yoshihisa Fujino, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

No observational study has examined whether cancer-related biomarkers are associated with diet in Japanese. We therefore assessed sex-specific food and nutrient intakes according to serum IGF-I, IGF-II, IGFBP-3, TGF-β1, total SOD activity and sFas levels, under a cross-sectional study of 10,350 control subjects who answered the food frequency questionnaire in the first-wave nested case-control study within the Japan Collaborative Cohort Study. For both men and women, IGF-I levels were associated with higher intakes of milk, fruits, green tea, calcium and vitamin C. IGF-II levels were associated with higher intakes of milk, yogurt, fruits and miso soup, and lower intakes of rice, coffee and carbohydrate. IGFBP-3 levels were associated with higher intakes of milk, yogurt, fruits and vitamin C, and lower intakes of rice, energy, protein, carbohydrate, sodium and polyunsaturated fatty acids. TGF-β1 levels were associated with lower intakes of coffee intakes, and higher intakes of miso soup and sodium. Total SOD activity levels were associated with lower intakes of most nutrients other than energy, carbohydrate, iron, copper, manganese, retinol equivalents, vitamin A, B2, B12, niacin, folic acid, vitamin C and fish fat. sFas levels were associated with higher intakes of manganese and folic acids. The results of the present study should help to account for findings on those biomarkers regarding risks of cancer and other lifestylerelated diseases in terms of dietary confounding as causality.

Original languageEnglish
Pages (from-to)7-22
Number of pages16
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 01-01-2009

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Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor II
Insulin-Like Growth Factor I
Ascorbic Acid
Soy Foods
Fruit
Yogurt
Milk
Eating
Coffee
Carbohydrates
Manganese
Vitamin A
Folic Acid
Food
Sodium
Serum
Riboflavin
Niacin
Tea

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Maruyama, Koutatsu ; Iso, Hiroyasu ; Ito, Yoshinori ; Watanabe, Yoshiyuki ; Inaba, Yutaka ; Tajima, Kazuo ; Nakachi, Kei ; Tamakoshi, Akiko ; Mori, Mitsuru ; Sakauchi, Fumio ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Tamakoshi, Koji ; Wakai, Kenji ; Tokudome, Shinkan ; Hashimoto, Shuji ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Yoshimura, Takesumi ; Fujino, Yoshihisa ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo. / Associations of Food and Nutrient Intakes with Serum IGF-I, IGF-II, IGFBP-3, TGF-β1, Total SOD Activity and sfas Levels among Middle-aged Japanese : The JACC Study. In: Asian Pacific Journal of Cancer Prevention. 2009 ; Vol. 10, No. SUPPL.1. pp. 7-22.
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title = "Associations of Food and Nutrient Intakes with Serum IGF-I, IGF-II, IGFBP-3, TGF-β1, Total SOD Activity and sfas Levels among Middle-aged Japanese: The JACC Study",
abstract = "No observational study has examined whether cancer-related biomarkers are associated with diet in Japanese. We therefore assessed sex-specific food and nutrient intakes according to serum IGF-I, IGF-II, IGFBP-3, TGF-β1, total SOD activity and sFas levels, under a cross-sectional study of 10,350 control subjects who answered the food frequency questionnaire in the first-wave nested case-control study within the Japan Collaborative Cohort Study. For both men and women, IGF-I levels were associated with higher intakes of milk, fruits, green tea, calcium and vitamin C. IGF-II levels were associated with higher intakes of milk, yogurt, fruits and miso soup, and lower intakes of rice, coffee and carbohydrate. IGFBP-3 levels were associated with higher intakes of milk, yogurt, fruits and vitamin C, and lower intakes of rice, energy, protein, carbohydrate, sodium and polyunsaturated fatty acids. TGF-β1 levels were associated with lower intakes of coffee intakes, and higher intakes of miso soup and sodium. Total SOD activity levels were associated with lower intakes of most nutrients other than energy, carbohydrate, iron, copper, manganese, retinol equivalents, vitamin A, B2, B12, niacin, folic acid, vitamin C and fish fat. sFas levels were associated with higher intakes of manganese and folic acids. The results of the present study should help to account for findings on those biomarkers regarding risks of cancer and other lifestylerelated diseases in terms of dietary confounding as causality.",
author = "Koutatsu Maruyama and Hiroyasu Iso and Yoshinori Ito and Yoshiyuki Watanabe and Yutaka Inaba and Kazuo Tajima and Kei Nakachi and Akiko Tamakoshi and Mitsuru Mori and Fumio Sakauchi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Kenji Wakai and Shinkan Tokudome and Shuji Hashimoto and Shogo Kikuchi and Yasuhiko Wada and Takashi Kawamura and Yoshiyuki Watanabe and Kotaro Ozasa and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Takesumi Yoshimura and Yoshihisa Fujino and Akira Shibata and Naoyuki Okamoto and Hideo Shio",
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Maruyama, K, Iso, H, Ito, Y, Watanabe, Y, Inaba, Y, Tajima, K, Nakachi, K, Tamakoshi, A, Mori, M, Sakauchi, F, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Tamakoshi, K, Wakai, K, Tokudome, S, Hashimoto, S, Kikuchi, S, Wada, Y, Kawamura, T, Watanabe, Y, Ozasa, K, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Yoshimura, T, Fujino, Y, Shibata, A, Okamoto, N & Shio, H 2009, 'Associations of Food and Nutrient Intakes with Serum IGF-I, IGF-II, IGFBP-3, TGF-β1, Total SOD Activity and sfas Levels among Middle-aged Japanese: The JACC Study', Asian Pacific Journal of Cancer Prevention, vol. 10, no. SUPPL.1, pp. 7-22.

Associations of Food and Nutrient Intakes with Serum IGF-I, IGF-II, IGFBP-3, TGF-β1, Total SOD Activity and sfas Levels among Middle-aged Japanese : The JACC Study. / Maruyama, Koutatsu; Iso, Hiroyasu; Ito, Yoshinori; Watanabe, Yoshiyuki; Inaba, Yutaka; Tajima, Kazuo; Nakachi, Kei; Tamakoshi, Akiko; Mori, Mitsuru; Sakauchi, Fumio; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Tamakoshi, Koji; Wakai, Kenji; Tokudome, Shinkan; Hashimoto, Shuji; Kikuchi, Shogo; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Yoshimura, Takesumi; Fujino, Yoshihisa; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo.

In: Asian Pacific Journal of Cancer Prevention, Vol. 10, No. SUPPL.1, 01.01.2009, p. 7-22.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations of Food and Nutrient Intakes with Serum IGF-I, IGF-II, IGFBP-3, TGF-β1, Total SOD Activity and sfas Levels among Middle-aged Japanese

T2 - The JACC Study

AU - Maruyama, Koutatsu

AU - Iso, Hiroyasu

AU - Ito, Yoshinori

AU - Watanabe, Yoshiyuki

AU - Inaba, Yutaka

AU - Tajima, Kazuo

AU - Nakachi, Kei

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Fujino, Yoshihisa

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2009/1/1

Y1 - 2009/1/1

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