TY - JOUR
T1 - Associations of Food and Nutrient Intakes with Serum IGF-I, IGF-II, IGFBP-3, TGF-β1, Total SOD Activity and sfas Levels among Middle-aged Japanese
T2 - The JACC Study
AU - Maruyama, Koutatsu
AU - Iso, Hiroyasu
AU - Ito, Yoshinori
AU - Watanabe, Yoshiyuki
AU - Inaba, Yutaka
AU - Tajima, Kazuo
AU - Nakachi, Kei
AU - Tamakoshi, Akiko
AU - Mori, Mitsuru
AU - Sakauchi, Fumio
AU - Motohashi, Yutaka
AU - Tsuji, Ichiro
AU - Nakamura, Yosikazu
AU - Mikami, Haruo
AU - Kurosawa, Michiko
AU - Hoshiyama, Yoshiharu
AU - Tanabe, Naohito
AU - Tamakoshi, Koji
AU - Wakai, Kenji
AU - Tokudome, Shinkan
AU - Hashimoto, Shuji
AU - Kikuchi, Shogo
AU - Wada, Yasuhiko
AU - Kawamura, Takashi
AU - Watanabe, Yoshiyuki
AU - Ozasa, Kotaro
AU - Miki, Tsuneharu
AU - Date, Chigusa
AU - Sakata, Kiyomi
AU - Kurozawa, Yoichi
AU - Yoshimura, Takesumi
AU - Fujino, Yoshihisa
AU - Shibata, Akira
AU - Okamoto, Naoyuki
AU - Shio, Hideo
PY - 2009/12
Y1 - 2009/12
N2 - No observational study has examined whether cancer-related biomarkers are associated with diet in Japanese. We therefore assessed sex-specific food and nutrient intakes according to serum IGF-I, IGF-II, IGFBP-3, TGF-β1, total SOD activity and sFas levels, under a cross-sectional study of 10,350 control subjects who answered the food frequency questionnaire in the first-wave nested case-control study within the Japan Collaborative Cohort Study. For both men and women, IGF-I levels were associated with higher intakes of milk, fruits, green tea, calcium and vitamin C. IGF-II levels were associated with higher intakes of milk, yogurt, fruits and miso soup, and lower intakes of rice, coffee and carbohydrate. IGFBP-3 levels were associated with higher intakes of milk, yogurt, fruits and vitamin C, and lower intakes of rice, energy, protein, carbohydrate, sodium and polyunsaturated fatty acids. TGF-β1 levels were associated with lower intakes of coffee intakes, and higher intakes of miso soup and sodium. Total SOD activity levels were associated with lower intakes of most nutrients other than energy, carbohydrate, iron, copper, manganese, retinol equivalents, vitamin A, B2, B12, niacin, folic acid, vitamin C and fish fat. sFas levels were associated with higher intakes of manganese and folic acids. The results of the present study should help to account for findings on those biomarkers regarding risks of cancer and other lifestylerelated diseases in terms of dietary confounding as causality.
AB - No observational study has examined whether cancer-related biomarkers are associated with diet in Japanese. We therefore assessed sex-specific food and nutrient intakes according to serum IGF-I, IGF-II, IGFBP-3, TGF-β1, total SOD activity and sFas levels, under a cross-sectional study of 10,350 control subjects who answered the food frequency questionnaire in the first-wave nested case-control study within the Japan Collaborative Cohort Study. For both men and women, IGF-I levels were associated with higher intakes of milk, fruits, green tea, calcium and vitamin C. IGF-II levels were associated with higher intakes of milk, yogurt, fruits and miso soup, and lower intakes of rice, coffee and carbohydrate. IGFBP-3 levels were associated with higher intakes of milk, yogurt, fruits and vitamin C, and lower intakes of rice, energy, protein, carbohydrate, sodium and polyunsaturated fatty acids. TGF-β1 levels were associated with lower intakes of coffee intakes, and higher intakes of miso soup and sodium. Total SOD activity levels were associated with lower intakes of most nutrients other than energy, carbohydrate, iron, copper, manganese, retinol equivalents, vitamin A, B2, B12, niacin, folic acid, vitamin C and fish fat. sFas levels were associated with higher intakes of manganese and folic acids. The results of the present study should help to account for findings on those biomarkers regarding risks of cancer and other lifestylerelated diseases in terms of dietary confounding as causality.
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M3 - Article
C2 - 20553076
AN - SCOPUS:77957340617
SN - 1513-7368
VL - 10
SP - 7
EP - 22
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - SUPPL.1
ER -
