Asthma: Comparison of dynamic oxygen-Enhanced mr imaging and quantitative thin-Section ct for evaluation of clinical treatment

Yoshiharu Ohno; Mizuho Nishio; Hisanobu Koyama; Shinichiro Seki; Takeshi Yoshikawa; Sumiaki Matsumoto; Makoto Obara; Marc Van Cauteren; Kazuro Sugimura

doi:10.1148/radiol.14132660

Asthma: Comparison of dynamic oxygen-Enhanced mr imaging and quantitative thin-Section ct for evaluation of clinical treatment

Yoshiharu Ohno, Mizuho Nishio, Hisanobu Koyama, Shinichiro Seki, Takeshi Yoshikawa, Sumiaki Matsumoto, Makoto Obara, Marc Van Cauteren, Kazuro Sugimura

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29 Citations (Scopus)

Abstract

Purpose: To compare the use of dynamic oxygen-enhanced magnetic resonance (MR) imaging with the use of quantitatively assessed computed tomography (CT) for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.

Materials and Methods: The institutional review board of Kobe University Hospital approved this study, and written informed consent was obtained from each subject. Thirty consecutive patients with asthma (17 men and 13 women; age range, 27-78 years) underwent dynamic oxygen-enhanced MR imaging, multidetector CT, and assessment of forced expiratory volume in 1 second. All patients were classified as having one of four stages of asthma according to the guidelines of the National Asthma Education and Prevention Program. Relative enhancement ratio (RER) and wash-in time maps were generated by means of pixel-by-pixel analyses. Regions of interest were placed on images of the lung in all sections, and all measurements were averaged to determine mean RER and mean wash-in time for each subject. Percentage of airway wall area and mean lung density were determined at quantitative CT. For comparison of the modalities for assessment of clinical stage, indexes of subjects at all clinical stages were compared by means of the Tukey honestly significant difference test. Evaluation of pulmonary functional improvement was assessed by correlating improvement of each index with that of forced expiratory volume.

Results: Mean wash-in time was significantly different among patients with asthma of different clinical stages (P ≤ .05), but significant differences between mean RER and percentage of airway wall area were observed for a limited number of clinical stages (P ≤ .05). Improvement of mean RER (r = 0.63, P = .0002) and mean wash-in time (r = 20.75, P ≤ .0001) was significantly correlated with forced expiratory volume.

Conclusion: Dynamic oxygen-enhanced MR imaging has potential as a tool for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.

Original language	English
Pages (from-to)	907-916
Number of pages	10
Journal	Radiology
Volume	273
Issue number	3
DOIs	https://doi.org/10.1148/radiol.14132660
Publication status	Published - 01-12-2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1148/radiol.14132660

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title = "Asthma: Comparison of dynamic oxygen-Enhanced mr imaging and quantitative thin-Section ct for evaluation of clinical treatment",

abstract = "Purpose: To compare the use of dynamic oxygen-enhanced magnetic resonance (MR) imaging with the use of quantitatively assessed computed tomography (CT) for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.Materials and Methods: The institutional review board of Kobe University Hospital approved this study, and written informed consent was obtained from each subject. Thirty consecutive patients with asthma (17 men and 13 women; age range, 27-78 years) underwent dynamic oxygen-enhanced MR imaging, multidetector CT, and assessment of forced expiratory volume in 1 second. All patients were classified as having one of four stages of asthma according to the guidelines of the National Asthma Education and Prevention Program. Relative enhancement ratio (RER) and wash-in time maps were generated by means of pixel-by-pixel analyses. Regions of interest were placed on images of the lung in all sections, and all measurements were averaged to determine mean RER and mean wash-in time for each subject. Percentage of airway wall area and mean lung density were determined at quantitative CT. For comparison of the modalities for assessment of clinical stage, indexes of subjects at all clinical stages were compared by means of the Tukey honestly significant difference test. Evaluation of pulmonary functional improvement was assessed by correlating improvement of each index with that of forced expiratory volume.Results: Mean wash-in time was significantly different among patients with asthma of different clinical stages (P ≤ .05), but significant differences between mean RER and percentage of airway wall area were observed for a limited number of clinical stages (P ≤ .05). Improvement of mean RER (r = 0.63, P = .0002) and mean wash-in time (r = 20.75, P ≤ .0001) was significantly correlated with forced expiratory volume.Conclusion: Dynamic oxygen-enhanced MR imaging has potential as a tool for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.",

author = "Yoshiharu Ohno and Mizuho Nishio and Hisanobu Koyama and Shinichiro Seki and Takeshi Yoshikawa and Sumiaki Matsumoto and Makoto Obara and {Van Cauteren}, Marc and Kazuro Sugimura",

note = "Publisher Copyright: {\textcopyright} RSNA, 2014.",

year = "2014",

month = dec,

day = "1",

doi = "10.1148/radiol.14132660",

language = "English",

volume = "273",

pages = "907--916",

journal = "Radiology",

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TY - JOUR

T1 - Asthma

T2 - Comparison of dynamic oxygen-Enhanced mr imaging and quantitative thin-Section ct for evaluation of clinical treatment

AU - Ohno, Yoshiharu

AU - Nishio, Mizuho

AU - Koyama, Hisanobu

AU - Seki, Shinichiro

AU - Yoshikawa, Takeshi

AU - Matsumoto, Sumiaki

AU - Obara, Makoto

AU - Van Cauteren, Marc

AU - Sugimura, Kazuro

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Purpose: To compare the use of dynamic oxygen-enhanced magnetic resonance (MR) imaging with the use of quantitatively assessed computed tomography (CT) for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.Materials and Methods: The institutional review board of Kobe University Hospital approved this study, and written informed consent was obtained from each subject. Thirty consecutive patients with asthma (17 men and 13 women; age range, 27-78 years) underwent dynamic oxygen-enhanced MR imaging, multidetector CT, and assessment of forced expiratory volume in 1 second. All patients were classified as having one of four stages of asthma according to the guidelines of the National Asthma Education and Prevention Program. Relative enhancement ratio (RER) and wash-in time maps were generated by means of pixel-by-pixel analyses. Regions of interest were placed on images of the lung in all sections, and all measurements were averaged to determine mean RER and mean wash-in time for each subject. Percentage of airway wall area and mean lung density were determined at quantitative CT. For comparison of the modalities for assessment of clinical stage, indexes of subjects at all clinical stages were compared by means of the Tukey honestly significant difference test. Evaluation of pulmonary functional improvement was assessed by correlating improvement of each index with that of forced expiratory volume.Results: Mean wash-in time was significantly different among patients with asthma of different clinical stages (P ≤ .05), but significant differences between mean RER and percentage of airway wall area were observed for a limited number of clinical stages (P ≤ .05). Improvement of mean RER (r = 0.63, P = .0002) and mean wash-in time (r = 20.75, P ≤ .0001) was significantly correlated with forced expiratory volume.Conclusion: Dynamic oxygen-enhanced MR imaging has potential as a tool for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.

AB - Purpose: To compare the use of dynamic oxygen-enhanced magnetic resonance (MR) imaging with the use of quantitatively assessed computed tomography (CT) for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.Materials and Methods: The institutional review board of Kobe University Hospital approved this study, and written informed consent was obtained from each subject. Thirty consecutive patients with asthma (17 men and 13 women; age range, 27-78 years) underwent dynamic oxygen-enhanced MR imaging, multidetector CT, and assessment of forced expiratory volume in 1 second. All patients were classified as having one of four stages of asthma according to the guidelines of the National Asthma Education and Prevention Program. Relative enhancement ratio (RER) and wash-in time maps were generated by means of pixel-by-pixel analyses. Regions of interest were placed on images of the lung in all sections, and all measurements were averaged to determine mean RER and mean wash-in time for each subject. Percentage of airway wall area and mean lung density were determined at quantitative CT. For comparison of the modalities for assessment of clinical stage, indexes of subjects at all clinical stages were compared by means of the Tukey honestly significant difference test. Evaluation of pulmonary functional improvement was assessed by correlating improvement of each index with that of forced expiratory volume.Results: Mean wash-in time was significantly different among patients with asthma of different clinical stages (P ≤ .05), but significant differences between mean RER and percentage of airway wall area were observed for a limited number of clinical stages (P ≤ .05). Improvement of mean RER (r = 0.63, P = .0002) and mean wash-in time (r = 20.75, P ≤ .0001) was significantly correlated with forced expiratory volume.Conclusion: Dynamic oxygen-enhanced MR imaging has potential as a tool for assessment of clinical stage and evaluation of pulmonary functional change due to treatment in patients with asthma.

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Asthma: Comparison of dynamic oxygen-Enhanced mr imaging and quantitative thin-Section ct for evaluation of clinical treatment

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