TY - JOUR
T1 - Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling
AU - Khuda, Imtiaz I.E.
AU - Koide, Naoki
AU - Noman, Abu S.M.
AU - Dagvadorj, Jargalsaikhan
AU - Tumurkhuu, Gantsetseg
AU - Naiki, Yoshikazu
AU - Komatsu, Takayuki
AU - Yoshida, Tomoaki
AU - Yokochi, Takashi
PY - 2009/9
Y1 - 2009/9
N2 - Astrocyte elevated gene-1 (AEG-1) is induced by human immunodeficiency virus 1 (HIV-1) infection and involved in tumour progression, migration and invasion as a nuclear factor-κB (NF-κB) -dependent gene. The involvement of AEG-1 on lipopolysaccharide (LPS) -induced proinflammatory cytokine production was examined. AEG-1 was induced via NF-κB activation in LPS-stimulated U937 human promonocytic cells. AEG-1 induced by LPS subsequently regulated NF-κB activation. The prevention of AEG-1 expression inhibited LPS-induced tumour necrosis factor-α and prostaglandin E2 production. The AEG-1 activation was not induced by toll-like receptor ligands other than LPS. Therefore, AEG-1 was suggested to be a LPS-responsive gene and involved in LPS-induced inflammatory response.
AB - Astrocyte elevated gene-1 (AEG-1) is induced by human immunodeficiency virus 1 (HIV-1) infection and involved in tumour progression, migration and invasion as a nuclear factor-κB (NF-κB) -dependent gene. The involvement of AEG-1 on lipopolysaccharide (LPS) -induced proinflammatory cytokine production was examined. AEG-1 was induced via NF-κB activation in LPS-stimulated U937 human promonocytic cells. AEG-1 induced by LPS subsequently regulated NF-κB activation. The prevention of AEG-1 expression inhibited LPS-induced tumour necrosis factor-α and prostaglandin E2 production. The AEG-1 activation was not induced by toll-like receptor ligands other than LPS. Therefore, AEG-1 was suggested to be a LPS-responsive gene and involved in LPS-induced inflammatory response.
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U2 - 10.1111/j.1365-2567.2009.03063.x
DO - 10.1111/j.1365-2567.2009.03063.x
M3 - Article
C2 - 19740331
AN - SCOPUS:68249158094
SN - 0019-2805
VL - 128
SP - e700-e706
JO - Immunology
JF - Immunology
IS - 1 PART 2
ER -
