Atazanavir-induced urine crystals demonstrated by infrared spectroscopic analysis

Isao Inagaki; Mariko Adachi; Hiroyasu Ito; Mitsuru Yasuda; Hisashi Tsurumi; Takashi Deguchi; Mitsuru Seishima

doi:10.1159/000354735

Atazanavir-induced urine crystals demonstrated by infrared spectroscopic analysis

Isao Inagaki, Mariko Adachi, Hiroyasu Ito, Mitsuru Yasuda, Hisashi Tsurumi, Takashi Deguchi, Mitsuru Seishima

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Atazanavir sulfate, an azapeptide inhibitor of HIV protease, has been associated with urolithiasis. A 60-year-old man with atazanavir-induced urinary sediment crystals verified by infrared spectroscopic analysis is described. He had been receiving highly active antiretroviral therapy (HAART) for HIV infection and also had a history of urinary lithiasis and been undergoing urinalysis once every month. Needle-shaped crystals were seen in his urine sediment and infrared spectroscopic analysis revealed that these were atazanavir crystals. Because the presence of the crystals in urine do not always reveal an abnormality in the urinary test strip analysis, the urinary sediment needed to be observed microscopically in order to prevent future urolithiasis and renal failure in this HIV patient receiving atazanavir.

Original language	English
Pages (from-to)	121-124
Number of pages	4
Journal	Urologia Internationalis
Volume	94
Issue number	1
DOIs	https://doi.org/10.1159/000354735
Publication status	Published - 24-02-2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Urology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Atazanavir sulfate, an azapeptide inhibitor of HIV protease, has been associated with urolithiasis. A 60-year-old man with atazanavir-induced urinary sediment crystals verified by infrared spectroscopic analysis is described. He had been receiving highly active antiretroviral therapy (HAART) for HIV infection and also had a history of urinary lithiasis and been undergoing urinalysis once every month. Needle-shaped crystals were seen in his urine sediment and infrared spectroscopic analysis revealed that these were atazanavir crystals. Because the presence of the crystals in urine do not always reveal an abnormality in the urinary test strip analysis, the urinary sediment needed to be observed microscopically in order to prevent future urolithiasis and renal failure in this HIV patient receiving atazanavir.",

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T1 - Atazanavir-induced urine crystals demonstrated by infrared spectroscopic analysis

AU - Inagaki, Isao

AU - Adachi, Mariko

AU - Ito, Hiroyasu

AU - Yasuda, Mitsuru

AU - Tsurumi, Hisashi

AU - Deguchi, Takashi

AU - Seishima, Mitsuru

PY - 2015/2/24

Y1 - 2015/2/24

N2 - Atazanavir sulfate, an azapeptide inhibitor of HIV protease, has been associated with urolithiasis. A 60-year-old man with atazanavir-induced urinary sediment crystals verified by infrared spectroscopic analysis is described. He had been receiving highly active antiretroviral therapy (HAART) for HIV infection and also had a history of urinary lithiasis and been undergoing urinalysis once every month. Needle-shaped crystals were seen in his urine sediment and infrared spectroscopic analysis revealed that these were atazanavir crystals. Because the presence of the crystals in urine do not always reveal an abnormality in the urinary test strip analysis, the urinary sediment needed to be observed microscopically in order to prevent future urolithiasis and renal failure in this HIV patient receiving atazanavir.

AB - Atazanavir sulfate, an azapeptide inhibitor of HIV protease, has been associated with urolithiasis. A 60-year-old man with atazanavir-induced urinary sediment crystals verified by infrared spectroscopic analysis is described. He had been receiving highly active antiretroviral therapy (HAART) for HIV infection and also had a history of urinary lithiasis and been undergoing urinalysis once every month. Needle-shaped crystals were seen in his urine sediment and infrared spectroscopic analysis revealed that these were atazanavir crystals. Because the presence of the crystals in urine do not always reveal an abnormality in the urinary test strip analysis, the urinary sediment needed to be observed microscopically in order to prevent future urolithiasis and renal failure in this HIV patient receiving atazanavir.

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Atazanavir-induced urine crystals demonstrated by infrared spectroscopic analysis

Abstract

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