Atherosclerotic plaque characterization by 0.5-mm-slice multislice computed tomographic imaging - Comparison with intravascular ultrasound

Sadako Motoyama, Takeshi Kondo, Hirofumi Anno, Atsushi Sugiura, Yoshihiro Ito, Kazumasa Mori, Junichi Ishii, Takahisa Sato, Kaori Inoue, Masayoshi Sarai, Hitoshi Hishida, Jagat Narula

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Abstract

Background: It has been proposed that 0.5-mm-slice multislice computed tomography (MSCT) is a noninvasive tool for the detection of atherosclerotic plaque, but the validity of such an assessment has not been demonstrated by an invasive investigation. The present study was performed to compare the 0.5-mm-slice MSCT density of plaques with intravascular ultrasound (IVUS) findings. Methods and Results: Atherosclerotic plaques were characterized in 37 consecutive patients undergoing percutaneous interventions. Based on the IVUS echogenecity, the plaques were classified as soft (n=18), fibrous (n=40) or calcified (n=40). In these 98 plaques, 0.5-mm-slice MSCT plaque density was calculated in 443 regions-of-interest, including 331 lesional foci and 112 luminal cross-sections, and represented as Hounsfield units (HU). MSCT density of the 3 types of plaque was 11±12 HU, 78±21 HU, and 516±198 HU respectively. Computed tomography density of the (contrast-filled) lumen was 258±43 HU. There were statistically highly significant differences in the densitometric characteristics among the 4 groups (soft, fibrous, calcified plaque and lumen) by nonparametric Kruskal-Wallis test (p<0.0001). Conclusions: The IVUS-based coronary plaque configuration can be accurately identified by 0.5-mm slice MSCT. Noninvasive assessment of plaque characterization will ensure emphasis on the vessel wall beyond the vascular lumen.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalCirculation Journal
Volume71
Issue number3
DOIs
Publication statusPublished - 19-03-2007

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Multidetector Computed Tomography
Atherosclerotic Plaques
Blood Vessels
Tomography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Motoyama, Sadako ; Kondo, Takeshi ; Anno, Hirofumi ; Sugiura, Atsushi ; Ito, Yoshihiro ; Mori, Kazumasa ; Ishii, Junichi ; Sato, Takahisa ; Inoue, Kaori ; Sarai, Masayoshi ; Hishida, Hitoshi ; Narula, Jagat. / Atherosclerotic plaque characterization by 0.5-mm-slice multislice computed tomographic imaging - Comparison with intravascular ultrasound. In: Circulation Journal. 2007 ; Vol. 71, No. 3. pp. 363-366.
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abstract = "Background: It has been proposed that 0.5-mm-slice multislice computed tomography (MSCT) is a noninvasive tool for the detection of atherosclerotic plaque, but the validity of such an assessment has not been demonstrated by an invasive investigation. The present study was performed to compare the 0.5-mm-slice MSCT density of plaques with intravascular ultrasound (IVUS) findings. Methods and Results: Atherosclerotic plaques were characterized in 37 consecutive patients undergoing percutaneous interventions. Based on the IVUS echogenecity, the plaques were classified as soft (n=18), fibrous (n=40) or calcified (n=40). In these 98 plaques, 0.5-mm-slice MSCT plaque density was calculated in 443 regions-of-interest, including 331 lesional foci and 112 luminal cross-sections, and represented as Hounsfield units (HU). MSCT density of the 3 types of plaque was 11±12 HU, 78±21 HU, and 516±198 HU respectively. Computed tomography density of the (contrast-filled) lumen was 258±43 HU. There were statistically highly significant differences in the densitometric characteristics among the 4 groups (soft, fibrous, calcified plaque and lumen) by nonparametric Kruskal-Wallis test (p<0.0001). Conclusions: The IVUS-based coronary plaque configuration can be accurately identified by 0.5-mm slice MSCT. Noninvasive assessment of plaque characterization will ensure emphasis on the vessel wall beyond the vascular lumen.",
author = "Sadako Motoyama and Takeshi Kondo and Hirofumi Anno and Atsushi Sugiura and Yoshihiro Ito and Kazumasa Mori and Junichi Ishii and Takahisa Sato and Kaori Inoue and Masayoshi Sarai and Hitoshi Hishida and Jagat Narula",
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Motoyama, S, Kondo, T, Anno, H, Sugiura, A, Ito, Y, Mori, K, Ishii, J, Sato, T, Inoue, K, Sarai, M, Hishida, H & Narula, J 2007, 'Atherosclerotic plaque characterization by 0.5-mm-slice multislice computed tomographic imaging - Comparison with intravascular ultrasound', Circulation Journal, vol. 71, no. 3, pp. 363-366. https://doi.org/10.1253/circj.71.363

Atherosclerotic plaque characterization by 0.5-mm-slice multislice computed tomographic imaging - Comparison with intravascular ultrasound. / Motoyama, Sadako; Kondo, Takeshi; Anno, Hirofumi; Sugiura, Atsushi; Ito, Yoshihiro; Mori, Kazumasa; Ishii, Junichi; Sato, Takahisa; Inoue, Kaori; Sarai, Masayoshi; Hishida, Hitoshi; Narula, Jagat.

In: Circulation Journal, Vol. 71, No. 3, 19.03.2007, p. 363-366.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Atherosclerotic plaque characterization by 0.5-mm-slice multislice computed tomographic imaging - Comparison with intravascular ultrasound

AU - Motoyama, Sadako

AU - Kondo, Takeshi

AU - Anno, Hirofumi

AU - Sugiura, Atsushi

AU - Ito, Yoshihiro

AU - Mori, Kazumasa

AU - Ishii, Junichi

AU - Sato, Takahisa

AU - Inoue, Kaori

AU - Sarai, Masayoshi

AU - Hishida, Hitoshi

AU - Narula, Jagat

PY - 2007/3/19

Y1 - 2007/3/19

N2 - Background: It has been proposed that 0.5-mm-slice multislice computed tomography (MSCT) is a noninvasive tool for the detection of atherosclerotic plaque, but the validity of such an assessment has not been demonstrated by an invasive investigation. The present study was performed to compare the 0.5-mm-slice MSCT density of plaques with intravascular ultrasound (IVUS) findings. Methods and Results: Atherosclerotic plaques were characterized in 37 consecutive patients undergoing percutaneous interventions. Based on the IVUS echogenecity, the plaques were classified as soft (n=18), fibrous (n=40) or calcified (n=40). In these 98 plaques, 0.5-mm-slice MSCT plaque density was calculated in 443 regions-of-interest, including 331 lesional foci and 112 luminal cross-sections, and represented as Hounsfield units (HU). MSCT density of the 3 types of plaque was 11±12 HU, 78±21 HU, and 516±198 HU respectively. Computed tomography density of the (contrast-filled) lumen was 258±43 HU. There were statistically highly significant differences in the densitometric characteristics among the 4 groups (soft, fibrous, calcified plaque and lumen) by nonparametric Kruskal-Wallis test (p<0.0001). Conclusions: The IVUS-based coronary plaque configuration can be accurately identified by 0.5-mm slice MSCT. Noninvasive assessment of plaque characterization will ensure emphasis on the vessel wall beyond the vascular lumen.

AB - Background: It has been proposed that 0.5-mm-slice multislice computed tomography (MSCT) is a noninvasive tool for the detection of atherosclerotic plaque, but the validity of such an assessment has not been demonstrated by an invasive investigation. The present study was performed to compare the 0.5-mm-slice MSCT density of plaques with intravascular ultrasound (IVUS) findings. Methods and Results: Atherosclerotic plaques were characterized in 37 consecutive patients undergoing percutaneous interventions. Based on the IVUS echogenecity, the plaques were classified as soft (n=18), fibrous (n=40) or calcified (n=40). In these 98 plaques, 0.5-mm-slice MSCT plaque density was calculated in 443 regions-of-interest, including 331 lesional foci and 112 luminal cross-sections, and represented as Hounsfield units (HU). MSCT density of the 3 types of plaque was 11±12 HU, 78±21 HU, and 516±198 HU respectively. Computed tomography density of the (contrast-filled) lumen was 258±43 HU. There were statistically highly significant differences in the densitometric characteristics among the 4 groups (soft, fibrous, calcified plaque and lumen) by nonparametric Kruskal-Wallis test (p<0.0001). Conclusions: The IVUS-based coronary plaque configuration can be accurately identified by 0.5-mm slice MSCT. Noninvasive assessment of plaque characterization will ensure emphasis on the vessel wall beyond the vascular lumen.

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