Atopic dermatitis-like symptoms in HR-1 hairless mice fed a diet low in magnesium and zinc

M. Makiura, H. Akamatsu, H. Akita, Akiko Yagami, Y. Shimizu, H. Eiro, M. Kuramoto, K. Suzuki, K. Matsunaga

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We aimed to develop an animal model for atopic dermatitis. HR-1 hairless mice fed a diet with reduced magnesium and zinc levels were compared with mice fed a standard diet. Skin dryness and wrinkle-like changes, scratching behaviour, decreased skin water content, increased transepidermal water loss and raised blood immunoglobulin E levels were seen in the group receiving the reduced magnesium and zinc diet compared with control mice. There were no significant differences in body weight or the weight of the major organs between the two groups. Haematological examination in both groups was normal apart from increased immunoglobulin E levels in mice fed a reduced magnesium and zinc diet. These mice may be useful models of atopic dermatitis; preparation of the animals is not particularly time consuming, the reproducibility is 100%, and atopic dermatitis symptoms occur even in a specific pathogen-free environment.

Original languageEnglish
Pages (from-to)392-399
Number of pages8
JournalJournal of International Medical Research
Volume32
Issue number4
DOIs
Publication statusPublished - 01-01-2004

Fingerprint

Hairless Mouse
Atopic Dermatitis
Nutrition
Magnesium
Zinc
Diet
Immunoglobulin E
Skin
Animals
Specific Pathogen-Free Organisms
Organ Size
Water
Pathogens
Water content
Blood
Animal Models
Body Weight

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

Makiura, M. ; Akamatsu, H. ; Akita, H. ; Yagami, Akiko ; Shimizu, Y. ; Eiro, H. ; Kuramoto, M. ; Suzuki, K. ; Matsunaga, K. / Atopic dermatitis-like symptoms in HR-1 hairless mice fed a diet low in magnesium and zinc. In: Journal of International Medical Research. 2004 ; Vol. 32, No. 4. pp. 392-399.
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Makiura, M, Akamatsu, H, Akita, H, Yagami, A, Shimizu, Y, Eiro, H, Kuramoto, M, Suzuki, K & Matsunaga, K 2004, 'Atopic dermatitis-like symptoms in HR-1 hairless mice fed a diet low in magnesium and zinc', Journal of International Medical Research, vol. 32, no. 4, pp. 392-399. https://doi.org/10.1177/147323000403200407

Atopic dermatitis-like symptoms in HR-1 hairless mice fed a diet low in magnesium and zinc. / Makiura, M.; Akamatsu, H.; Akita, H.; Yagami, Akiko; Shimizu, Y.; Eiro, H.; Kuramoto, M.; Suzuki, K.; Matsunaga, K.

In: Journal of International Medical Research, Vol. 32, No. 4, 01.01.2004, p. 392-399.

Research output: Contribution to journalArticle

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AU - Akamatsu, H.

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