TY - JOUR
T1 - Attenuation of benzodiazepine-induced passive avoidance deficit by post-training administration of muscimol
T2 - interaction with the cholinergic neuronal system
AU - Nabeshima, Toshitaka
AU - Tohyama, Keiko
AU - Ichihara, Kenji
AU - Kameyama, Tsutomu
N1 - Funding Information:
We are grateful to Hoffman-La Roche for the generous gift of flumazenil and to Mr. K. Murase and Mr. S. Ishihara for typing the manuscript. This study was partly supported by a Grant-in-Aid from the Takeda Science Foundation.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1990/7/17
Y1 - 1990/7/17
N2 - We examined the involvement of GABAergic neuronal systems in benzodiazepine-induced passive avoidance deficit. Chlordiazepoxide impaired the passive avoidance response dose dependently when it was given prior to training. Post-training administration of muscimol improved the performance of chlordiazepoxide-pretreated mice. The effects of muscimol were antagonized completely by the GABAA antagonist, bicuculline, and the muscarinic acetycholine receptor antaagonist, scopolamine, but not by the benzodiazepine receptor antagonist, flumazenil, when the latter was administered immediately after training. It appears from these results that the GABAergic neuronal system plays an important role in the benzodiazepine-induced passive avoidance deficit by interacting with the cholinergic neuronal system.
AB - We examined the involvement of GABAergic neuronal systems in benzodiazepine-induced passive avoidance deficit. Chlordiazepoxide impaired the passive avoidance response dose dependently when it was given prior to training. Post-training administration of muscimol improved the performance of chlordiazepoxide-pretreated mice. The effects of muscimol were antagonized completely by the GABAA antagonist, bicuculline, and the muscarinic acetycholine receptor antaagonist, scopolamine, but not by the benzodiazepine receptor antagonist, flumazenil, when the latter was administered immediately after training. It appears from these results that the GABAergic neuronal system plays an important role in the benzodiazepine-induced passive avoidance deficit by interacting with the cholinergic neuronal system.
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U2 - 10.1016/0014-2999(90)90055-B
DO - 10.1016/0014-2999(90)90055-B
M3 - Article
C2 - 1977593
AN - SCOPUS:0025035503
VL - 182
SP - 555
EP - 560
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -