Augmentation by cor ynebacterium liq uefaciens of erythrocyte surface H-2 expression and alloimmunogenicity for antibody responses

Tomoaki Yoshida, Izumi Nakashima, Takashi Yokochi, Kenji Mizoguchi, Rin Na Ding, Nobuo Kato, Ken Ichi Isobe, Fumihiko Nagase, Ko Ichi Ando, Takashi Iwamoto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Intravenous injection of killed Corynebacterium li- quefaciens induced a population of red blood cells that expressed both H-2K and H-2D antigens at exceptionally high density and displayed augmented immunoge- nicity for H-2 alloantigen-specific B cell activation. Injection of killed Escherichia coli or E. coli lipopolysac- charide was ineffective for the generation of such RBC. RBC that express H-2 antigens at high density first appeared at 7 days after injection of C. liquefaciens. These RBC persisted for more than 50 days, although they lost H-2 antigens gradually with time. The observed phenomenon was not due to enhanced erythro- poiesis and peripheral release of immature RBC (reticulocytes); populations of both mature and immature RBC of mice injected with C. liquefaciens expressed H- 2 antigens at high density, whereas those from normal mice or mice injected with phenyl hydrazine did not. Appearance of RBC expressing H-2 antigens at high density was preceded by a temporal increase in H-2 expression of bone marrow cells that included precursors of RBC. It was concluded that RBC expressing H-2 antigens at high density were descendants of bone marrow cells whose H-2 expression was augmented by C. liquefaciens. The present communication would be the 1st report of the bacteria-mediated augmentation of cell surface expression and activity of major-histocompati- bility-compex class I antigens on host cells in vivo.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalTransplantation
Volume46
Issue number2
DOIs
Publication statusPublished - 08-1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Transplantation

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