TY - JOUR
T1 - Augmentation of skin flap survival by selective intraarterial infusion of prostaglandin E1
T2 - Experimental and clinical studies
AU - Okamoto, Y.
AU - Nakajima, T.
AU - Yoneda, K.
PY - 1993
Y1 - 1993
N2 - Prostaglandin E1 has been proven to be useful in the treatment of vascular diseases of the lower leg. Plastic surgeons have been aware of its usefulness in augmenting flap survival and have used it intraarterially or intravenously. We attempted to enhance the effect of prostaglandin E1 with heparin by local continuous intraarterial infusion of both drugs. First, we assessed the viability area of an experimental island flap model on rabbit abdomen, and confirmed the usefulness of this method. Next, we attempted to develop clinical cases using Seldinger's method. By this method, we were able to rescue the flaps with circulatory insufficiency and gain a larger survival area of an axial pattern flap.
AB - Prostaglandin E1 has been proven to be useful in the treatment of vascular diseases of the lower leg. Plastic surgeons have been aware of its usefulness in augmenting flap survival and have used it intraarterially or intravenously. We attempted to enhance the effect of prostaglandin E1 with heparin by local continuous intraarterial infusion of both drugs. First, we assessed the viability area of an experimental island flap model on rabbit abdomen, and confirmed the usefulness of this method. Next, we attempted to develop clinical cases using Seldinger's method. By this method, we were able to rescue the flaps with circulatory insufficiency and gain a larger survival area of an axial pattern flap.
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U2 - 10.1097/00000637-199302000-00010
DO - 10.1097/00000637-199302000-00010
M3 - Article
C2 - 8489180
AN - SCOPUS:0027523107
SN - 0148-7043
VL - 30
SP - 154
EP - 158
JO - Annals of Plastic Surgery
JF - Annals of Plastic Surgery
IS - 2
ER -