Aurora-A - A guardian of poles

Tomotoshi Marumoto; Dongwei Zhang; Hideyuki Saya

doi:10.1038/nrc1526

Aurora-A - A guardian of poles

Tomotoshi Marumoto
, Dongwei Zhang
, Hideyuki Saya

Research output: Contribution to journal › Review article › peer-review

677 Citations (Scopus)

Abstract

The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

Original language	English
Pages (from-to)	42-50
Number of pages	9
Journal	Nature Reviews Cancer
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/nrc1526
Publication status	Published - 01-2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1038/nrc1526

Cite this

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abstract = "The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?",

author = "Tomotoshi Marumoto and Dongwei Zhang and Hideyuki Saya",

note = "Funding Information: We thank T. Hirota, T. Sasayama, S. Iida, S. Kuninaka, T. Hara, N. Kunitoku, N. Araki and T. Mimori for helpful discussion. This work was supported by a grant for Cancer Research from the Ministry of Education, Science and Culture of Japan (H.S.) and {\textquoteleft}Research for the Future{\textquoteright} programme of the Japan Society for the Promotion of Science (H.S.).",

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AU - Zhang, Dongwei

AU - Saya, Hideyuki

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N2 - The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

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Aurora-A - A guardian of poles

Abstract

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