TY - JOUR
T1 - Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection
T2 - Case report
AU - Ohsawa, Isao
AU - Uehara, Yuki
AU - Hashimoto, Sumiko
AU - Endo, Morito
AU - Fujita, Takayuki
AU - Ohi, Hiroyuki
PY - 2003/8/29
Y1 - 2003/8/29
N2 - Background: Renal involvement in patients with chronic hepatitis C virus infection has suggested to be due to a variety of immunological processes. However, the precise mechanism which the kidneys are damaged in these patients is still unclear. Case presentation: A 66 year old man presented with the sudden onset of autoimmune hemolytic anemia. Concomitant with a worsening of hemolysis, his initially mild proteinuria hemoglobinuria progressed. On admission, laboratory tests revealed that he was positive hepatitis C virus in his blood, though his liver function tests were all normal. The patient displayed cryoglobulinemia and hypocomplementemia with cold activation, and exhibited a biological positive of syphilic test. Renal biopsy specimens showed signs of immune complex nephropathy with hemosiderin deposition in the tubular epithelial cells. Conclusions: The renal histological findings in this case are consistent with the deposition immune complexes and hemolytic products, which might have occurred as a result of the patient's underlying autoimmune imbalance, autoimmune hemolytic anemia, and chronic hepatitis C infection.
AB - Background: Renal involvement in patients with chronic hepatitis C virus infection has suggested to be due to a variety of immunological processes. However, the precise mechanism which the kidneys are damaged in these patients is still unclear. Case presentation: A 66 year old man presented with the sudden onset of autoimmune hemolytic anemia. Concomitant with a worsening of hemolysis, his initially mild proteinuria hemoglobinuria progressed. On admission, laboratory tests revealed that he was positive hepatitis C virus in his blood, though his liver function tests were all normal. The patient displayed cryoglobulinemia and hypocomplementemia with cold activation, and exhibited a biological positive of syphilic test. Renal biopsy specimens showed signs of immune complex nephropathy with hemosiderin deposition in the tubular epithelial cells. Conclusions: The renal histological findings in this case are consistent with the deposition immune complexes and hemolytic products, which might have occurred as a result of the patient's underlying autoimmune imbalance, autoimmune hemolytic anemia, and chronic hepatitis C infection.
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U2 - 10.1186/1471-2369-4-7
DO - 10.1186/1471-2369-4-7
M3 - Article
C2 - 12946280
AN - SCOPUS:2942720674
SN - 1471-2369
VL - 4
SP - 1
EP - 7
JO - BMC Nephrology
JF - BMC Nephrology
M1 - 7
ER -
