Autologous fat injection therapy including a high concentration of adipose-derived regenerative cells in a vocal fold paralysis model: Animal pilot study

N. Nishio, Y. Fujimoto, K. Suga, Y. Iwata, K. Toriyama, K. Takanari, Y. Kamei, T. Yamamoto, M. Gotoh

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Objectives: To verify the effectiveness and safety of the addition of adipose-derived regenerative cells to autologous fat injection therapy. Methods: Unilateral vocal fold paralysis models were made by cutting the right recurrent laryngeal nerve in two pigs. At day 30, 0.5 ml adipose-derived regenerative cells mixed with 1 ml autologous fat was injected into the right vocal fold of one pig, with the other receiving 0.5 ml Ringer's solution mixed with 1 ml autologous fat. At day 120, fibrescopy, laser Doppler flowmeter, computed tomography, vocal function evaluation and histological assessment were conducted. Results: Although histological assessment revealed atrophy of the thyroarytenoid muscle fibre in both pigs, there was remarkable hypertrophy of the thyroarytenoid muscle fibre in the area surrounding the adipose-derived regenerative cells injection site. Conclusion: The addition of a high concentration of adipose-derived regenerative cells to autologous fat injection therapy has the potential to improve the treatment outcome for unilateral vocal fold paralysis.

Original languageEnglish
Pages (from-to)914-922
Number of pages9
JournalJournal of Laryngology and Otology
Volume130
Issue number10
DOIs
Publication statusPublished - 01-10-2016

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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