TY - JOUR
T1 - Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis
AU - Suzuki, Shigeaki
AU - Tanaka, Kortaro
AU - Yasuoka, Hidekata
AU - Fukuuchi, Yasuo
AU - Kawakami, Yutaka
AU - Kuwana, Masataka
N1 - Funding Information:
We thank Y. Okazaki and K. Kimura for their excellent technical assistance, Dr. T. Fujita and Dr. K. Dan for preparing the synthetic peptides, and Dr. A. Koto, Dr. T. Amano, Dr. N. Tanahashi, Dr. J. Hamada, and Dr. S. Nogawa for coordinating the blood specimen collection. This work was supported by a grant from the Japanese Ministry of Education, Science, Sports and Culture and the Keio University Medical Science Fund.
PY - 2003/4
Y1 - 2003/4
N2 - In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.
AB - In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.
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U2 - 10.1016/S0165-5728(03)00078-X
DO - 10.1016/S0165-5728(03)00078-X
M3 - Article
C2 - 12667662
AN - SCOPUS:0037376649
SN - 0165-5728
VL - 137
SP - 177
EP - 186
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -