Axonal injury in experimental herpes simplex encephalitis

Isamu Mori; Fumi Goshima; Terukazu Mizuno; Yoshinori Imai; Shinichi Kohsaka; Hiroyasu Ito; Naoki Koide; Tomoaki Yoshida; Takashi Yokochi; Yoshinobu Kimura; Yukihiro Nishiyama

doi:10.1016/j.brainres.2005.07.037

Axonal injury in experimental herpes simplex encephalitis

Isamu Mori, Fumi Goshima, Terukazu Mizuno, Yoshinori Imai, Shinichi Kohsaka, Hiroyasu Ito, Naoki Koide, Tomoaki Yoshida, Takashi Yokochi, Yoshinobu Kimura, Yukihiro Nishiyama

Medical Biology

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Using β-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. β-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis.

Original language	English
Pages (from-to)	186-190
Number of pages	5
Journal	Brain Research
Volume	1057
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainres.2005.07.037
Publication status	Published - 28-09-2005

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2005.07.037

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title = "Axonal injury in experimental herpes simplex encephalitis",

abstract = "Using β-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. β-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis.",

author = "Isamu Mori and Fumi Goshima and Terukazu Mizuno and Yoshinori Imai and Shinichi Kohsaka and Hiroyasu Ito and Naoki Koide and Tomoaki Yoshida and Takashi Yokochi and Yoshinobu Kimura and Yukihiro Nishiyama",

note = "Funding Information: We thank E. Iwata and T. Tsuruguchi for technical assistance. This work was supported by a Grant-in-Aid for Science Research from the Japan Society for the Promotion of Science (JSPS) (15590424). I. Mori is the recipient of an Encouragement of Young Scientist Award (2004) from the Nakanihon Infectious Diseases Research Foundation, Japan.",

year = "2005",

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day = "28",

doi = "10.1016/j.brainres.2005.07.037",

language = "English",

volume = "1057",

pages = "186--190",

journal = "Brain Research",

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publisher = "Elsevier B.V.",

number = "1-2",

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TY - JOUR

T1 - Axonal injury in experimental herpes simplex encephalitis

AU - Mori, Isamu

AU - Goshima, Fumi

AU - Mizuno, Terukazu

AU - Imai, Yoshinori

AU - Kohsaka, Shinichi

AU - Ito, Hiroyasu

AU - Koide, Naoki

AU - Yoshida, Tomoaki

AU - Yokochi, Takashi

AU - Kimura, Yoshinobu

AU - Nishiyama, Yukihiro

N1 - Funding Information: We thank E. Iwata and T. Tsuruguchi for technical assistance. This work was supported by a Grant-in-Aid for Science Research from the Japan Society for the Promotion of Science (JSPS) (15590424). I. Mori is the recipient of an Encouragement of Young Scientist Award (2004) from the Nakanihon Infectious Diseases Research Foundation, Japan.

PY - 2005/9/28

Y1 - 2005/9/28

N2 - Using β-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. β-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis.

AB - Using β-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. β-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis.

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DO - 10.1016/j.brainres.2005.07.037

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VL - 1057

SP - 186

EP - 190

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Axonal injury in experimental herpes simplex encephalitis

Abstract

All Science Journal Classification (ASJC) codes

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