Balance between angiogenic and anti-angiogenic isoforms of VEGF-A is associated with the complexity and severity of coronary artery disease

Yohei Shibata, Ryosuke Kikuchi, Hideki Ishii, Susumu Suzuki, Kazuhiro Harada, Kenshi Hirayama, Atsuo Suzuki, Yosuke Tatami, Kazuhisa Kondo, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Introduction Assessing the complexity of coronary artery disease (CAD) is clinically important. Vascular endothelial growth factor A (VEGF-A) is a powerful and the most important regulator of angiogenesis. It has been reported that the anti-angiogenic isoform of VEGF-A (VEGF-A165b) inhibits angiogenesis. The purpose of this study was to evaluate the relationship between the complexities of CAD using the Syntax score (SS) and the levels of circulating total VEGF-A or VEGF-A165b. Methods A total of 268 patients who underwent percutaneous coronary intervention (PCI) were enrolled. Of these, 73 patients without acute coronary syndrome or previous revascularization were included in this study. These subjects were divided into two groups according to the SS. Circulating total VEGF-A and VEGF-A165b levels were measured using an enzyme-linked immunosorbent assay. Results Circulating levels of total VEGF-A were significantly higher in the SS > 22 (high SS) group than in the SS ≤ 22 (low SS) group (p = 0.018). Moreover, the ratio of VEGF-A165b to total VEGF-A was significantly lower for the high SS group (p = 0.004). The levels of total VEGF-A independently predicted high SS after adjusting for other significant variables among patients who underwent PCI (odds ratio, 1.004; 95% CI, 1.001 to 1.006; p = 0.01). Conclusions These data indicated that high SS was associated with circulating levels of total VEGF-A and the ratio of VEGF-A165b to total VEGF-A in patients with complex CAD.

Original languageEnglish
Pages (from-to)114-119
Number of pages6
JournalClinica Chimica Acta
Volume478
DOIs
Publication statusPublished - 03-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint

Dive into the research topics of 'Balance between angiogenic and anti-angiogenic isoforms of VEGF-A is associated with the complexity and severity of coronary artery disease'. Together they form a unique fingerprint.

Cite this