OBJECTIVE: To study the cytomorphologic features of bar-shaped chromatin in conjunctival samples and assess whether there are morphologic similarities between nuclear grooves seen in thyroid papillary carcinoma and bar-shaped chromatin. STUDY DESIGN: A total of 10 conjunctival samples from five volunteers were studied cytologically. Of the 10 samples, 2 showed bar- shaped chromatin. This chromatin was studied using a light microscope, scanning electron microscope (SEM) and transmission electron microscope (TEM). RESULTS: On SEM, bar-shaped chromatin was observed as a fissure or shallow cracks. On TEM the bar-shaped chromatin existed both in the center of the nuclei and in the nuclear membrane and cytoplasm. It was surrounded by outer and inner membranes. CONCLUSION: It seems that bar-shaped chromatin is formed by the nuclear membrane and that these changes are essentially the same configuration as cytoplasmic invaginations commonly present in papillary carcinoma of the thyroid.
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine