Basic and clinical studies on bay a 1040 with special reference to its influence on the coronary, systemic resistance and capacitance blood vessels

Shoji Hayase, Senri Hirakawa, Sadamasa Hosokawa, Noriyasu Mori, Hiroyasu Ito, Yasushi Kondo, Kunihiko Hiei, Shohachi Banno

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A series of basic and clinical studies on a new Antianginal agent, Bay a 1040, revealed the following facts. 1. With the artificial perfusion of a large branch of the coronary artery under a constant pressure head in closed-chest dogs, and with intracoronary injection as a bolus of 0.1 ml, 1.0 μg of Bay a 1040 produced a transient and minimal decrease in the mean coronary resistance to flow without any change in blood pressures. With 5 μg/kg injected intravenously, the mean resistance to flow decreased in the coronary area that was not exposed to the circulating Bay a 1040. From these observations it is probable that Bay a 1040 produces a mild “active” coronary dilatation as well as “passive” coronary dilatation. 2. With 5 μg/kg injected intravenously in open-chest dogs, the evoked circulatory change was that of transient dilatation of the systemic resistance vessels without any change in the capacitance of the circulatory system. 3. Middle-aged patients with ischemic heart disease responded to the oral administration of 20 mg with “dilatation” of the systemic resistance vessels. Left ventricular external work and pressure-time-product were also diminished. 4. A clinical trial with cross-over design revealed an outstanding. “preventive” efficacy of this agent, as given in daily dose of 60 mg in 3 divided portions, on the occurrence of anginal attacks in the patients with ischemic heart disease.

Original languageEnglish
Pages (from-to)903-914
Number of pages12
JournalJAPANESE CIRCULATION JOURNAL
Volume35
Issue number8
DOIs
Publication statusPublished - 1971
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

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