Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction

Noritoshi Kato, Tomoki Kosugi, Waichi Sato, Takuji Ishimoto, Hiroshi Kojima, Yuka Sato, Kazuma Sakamoto, Shoichi Maruyama, Yukio Yuzawa, Seiichi Matsuo, Kenji Kadomatsu

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Regardless of their primary causes, progressive renal fibrosis and tubular atrophy are the main predictors of progression to end-stage renal disease. Basigin/ CD147 is a multifunctional molecule - it induces matrix metalloproteinases and hyaluronan, for example - and has been implicated in organ fibrosis. However, the relationship between basigin and organ fibrosis has been poorly studied. We investigated basigin's role in renal fibrosis using a unilateral ureteral obstruction model. Basigin-deficient mice (Bsg -/-) demonstrated significantly less fibrosis after surgery than Bsg+/+ mice. Fewer macrophages had infiltrated in Bsg-/- kidneys. Consistent with these in vivo data, primary cultured tubular epithelial cells from Bsg-/- mice produced less matrix metalloproteinase and exhibited less motility on stimulation with transforming growth factor β. Furthermore, Bsg-/- embryonic fibro blasts produced less hyaluronan and α-smooth muscle actin after transforming growth factor β stimulation. Together, these results demonstrate for the first time that basigin is a key regulator of renal fibrosis. Basigin could be a candidate target molecule for the prevention of organ fibrosis.

Original languageEnglish
Pages (from-to)572-579
Number of pages8
JournalAmerican Journal of Pathology
Volume178
Issue number2
DOIs
Publication statusPublished - 01-01-2011
Externally publishedYes

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CD147 Antigens
Ureteral Obstruction
Fibrosis
Kidney
Transforming Growth Factors
Hyaluronic Acid
Matrix Metalloproteinases
Chronic Kidney Failure
Atrophy
Smooth Muscle
Actins
Epithelial Cells
Macrophages

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Kato, N., Kosugi, T., Sato, W., Ishimoto, T., Kojima, H., Sato, Y., ... Kadomatsu, K. (2011). Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. American Journal of Pathology, 178(2), 572-579. https://doi.org/10.1016/j.ajpath.2010.10.009
Kato, Noritoshi ; Kosugi, Tomoki ; Sato, Waichi ; Ishimoto, Takuji ; Kojima, Hiroshi ; Sato, Yuka ; Sakamoto, Kazuma ; Maruyama, Shoichi ; Yuzawa, Yukio ; Matsuo, Seiichi ; Kadomatsu, Kenji. / Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. In: American Journal of Pathology. 2011 ; Vol. 178, No. 2. pp. 572-579.
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Kato, N, Kosugi, T, Sato, W, Ishimoto, T, Kojima, H, Sato, Y, Sakamoto, K, Maruyama, S, Yuzawa, Y, Matsuo, S & Kadomatsu, K 2011, 'Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction', American Journal of Pathology, vol. 178, no. 2, pp. 572-579. https://doi.org/10.1016/j.ajpath.2010.10.009

Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. / Kato, Noritoshi; Kosugi, Tomoki; Sato, Waichi; Ishimoto, Takuji; Kojima, Hiroshi; Sato, Yuka; Sakamoto, Kazuma; Maruyama, Shoichi; Yuzawa, Yukio; Matsuo, Seiichi; Kadomatsu, Kenji.

In: American Journal of Pathology, Vol. 178, No. 2, 01.01.2011, p. 572-579.

Research output: Contribution to journalArticle

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AU - Sato, Yuka

AU - Sakamoto, Kazuma

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AU - Yuzawa, Yukio

AU - Matsuo, Seiichi

AU - Kadomatsu, Kenji

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