Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction

Noritoshi Kato, Tomoki Kosugi, Waichi Sato, Takuji Ishimoto, Hiroshi Kojima, Yuka Sato, Kazuma Sakamoto, Shoichi Maruyama, Yukio Yuzawa, Seiichi Matsuo, Kenji Kadomatsu

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Abstract

Regardless of their primary causes, progressive renal fibrosis and tubular atrophy are the main predictors of progression to end-stage renal disease. Basigin/ CD147 is a multifunctional molecule - it induces matrix metalloproteinases and hyaluronan, for example - and has been implicated in organ fibrosis. However, the relationship between basigin and organ fibrosis has been poorly studied. We investigated basigin's role in renal fibrosis using a unilateral ureteral obstruction model. Basigin-deficient mice (Bsg -/-) demonstrated significantly less fibrosis after surgery than Bsg+/+ mice. Fewer macrophages had infiltrated in Bsg-/- kidneys. Consistent with these in vivo data, primary cultured tubular epithelial cells from Bsg-/- mice produced less matrix metalloproteinase and exhibited less motility on stimulation with transforming growth factor β. Furthermore, Bsg-/- embryonic fibro blasts produced less hyaluronan and α-smooth muscle actin after transforming growth factor β stimulation. Together, these results demonstrate for the first time that basigin is a key regulator of renal fibrosis. Basigin could be a candidate target molecule for the prevention of organ fibrosis.

Original languageEnglish
Pages (from-to)572-579
Number of pages8
JournalAmerican Journal of Pathology
Volume178
Issue number2
DOIs
Publication statusPublished - 02-2011

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Kato, N., Kosugi, T., Sato, W., Ishimoto, T., Kojima, H., Sato, Y., Sakamoto, K., Maruyama, S., Yuzawa, Y., Matsuo, S., & Kadomatsu, K. (2011). Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. American Journal of Pathology, 178(2), 572-579. https://doi.org/10.1016/j.ajpath.2010.10.009