Beat-to-beat variability of T-wave amplitude for the risk assessment of ventricular tachyarrhythmia in patients without structural heart disease

Yoshihiro Sobue, Eiichi Watanabe, Mayumi Yamamoto, Kan Sano, Hiroto Harigaya, Kentarou Okuda, Yukio Ozaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aims Increased temporal repolarization lability, assessed by beat-to-beat variability of T-wave amplitude (TAV), has been shown to be associated with ventricular tachyarrhythmia in patients with a variety of clinical conditions. The aim of this study was to test the ability of TAV to identify patients presenting with malignant ventricular arrhythmia and to predict subsequent occurrences. Methods and results We studied 20 consecutive patients (age 42 ± 15 years, mean ± standard deviation) presenting with ventricular tachyarrhythmia who did not have substantial underlying heart disease and compared them with 40 age- and sex-matched control subjects. The TAV was determined by Holter recording (Ela Medical). Patients with ventricular tachyarrhythmia had a higher maximum value of TAV (max TAV: 38 ± 18 vs. 22 ± 15 μV, P< 0.001) than did the controls. The sensitivity and specificity of max TAV>22.4 μV for detecting the occurrence of ventricular tachyarrhythmia were 77 and 90%, respectively. During a mean follow-up period of 23 months, three patients had relapses of ventricular tachyarrhythmia. Patients with a recurrence of ventricular tachyarrhythmia had a trend towards a higher max TAV as compared with those who had ventricular tachyarrhythmia but did not relapse (56 ± 23 vs. 36 ± 16 μV, P = 0.061). Conclusion Our results suggest that Holter-derived TAV might be associated with the occurrence and recurrence of ventricular tachyarrhythmia in patients without structural heart disease. Prospective validation will be necessary to assess the potential diagnostic value of the TAV in a large general population.

Original languageEnglish
Pages (from-to)1612-1618
Number of pages7
JournalEuropace
Volume13
Issue number11
DOIs
Publication statusPublished - 01-11-2011

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Tachycardia
Heart Diseases
Recurrence
Cardiac Arrhythmias
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Sobue, Yoshihiro ; Watanabe, Eiichi ; Yamamoto, Mayumi ; Sano, Kan ; Harigaya, Hiroto ; Okuda, Kentarou ; Ozaki, Yukio. / Beat-to-beat variability of T-wave amplitude for the risk assessment of ventricular tachyarrhythmia in patients without structural heart disease. In: Europace. 2011 ; Vol. 13, No. 11. pp. 1612-1618.
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Beat-to-beat variability of T-wave amplitude for the risk assessment of ventricular tachyarrhythmia in patients without structural heart disease. / Sobue, Yoshihiro; Watanabe, Eiichi; Yamamoto, Mayumi; Sano, Kan; Harigaya, Hiroto; Okuda, Kentarou; Ozaki, Yukio.

In: Europace, Vol. 13, No. 11, 01.11.2011, p. 1612-1618.

Research output: Contribution to journalArticle

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T1 - Beat-to-beat variability of T-wave amplitude for the risk assessment of ventricular tachyarrhythmia in patients without structural heart disease

AU - Sobue, Yoshihiro

AU - Watanabe, Eiichi

AU - Yamamoto, Mayumi

AU - Sano, Kan

AU - Harigaya, Hiroto

AU - Okuda, Kentarou

AU - Ozaki, Yukio

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N2 - Aims Increased temporal repolarization lability, assessed by beat-to-beat variability of T-wave amplitude (TAV), has been shown to be associated with ventricular tachyarrhythmia in patients with a variety of clinical conditions. The aim of this study was to test the ability of TAV to identify patients presenting with malignant ventricular arrhythmia and to predict subsequent occurrences. Methods and results We studied 20 consecutive patients (age 42 ± 15 years, mean ± standard deviation) presenting with ventricular tachyarrhythmia who did not have substantial underlying heart disease and compared them with 40 age- and sex-matched control subjects. The TAV was determined by Holter recording (Ela Medical). Patients with ventricular tachyarrhythmia had a higher maximum value of TAV (max TAV: 38 ± 18 vs. 22 ± 15 μV, P< 0.001) than did the controls. The sensitivity and specificity of max TAV>22.4 μV for detecting the occurrence of ventricular tachyarrhythmia were 77 and 90%, respectively. During a mean follow-up period of 23 months, three patients had relapses of ventricular tachyarrhythmia. Patients with a recurrence of ventricular tachyarrhythmia had a trend towards a higher max TAV as compared with those who had ventricular tachyarrhythmia but did not relapse (56 ± 23 vs. 36 ± 16 μV, P = 0.061). Conclusion Our results suggest that Holter-derived TAV might be associated with the occurrence and recurrence of ventricular tachyarrhythmia in patients without structural heart disease. Prospective validation will be necessary to assess the potential diagnostic value of the TAV in a large general population.

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