TY - JOUR
T1 - Bedroom light exposure at night and obesity in individuals with bipolar disorder
T2 - A cross-sectional analysis of the APPLE cohort
AU - Esaki, Yuichi
AU - Obayashi, Kenji
AU - Saeki, Keigo
AU - Fujita, Kiyoshi
AU - Iwata, Nakao
AU - Kitajima, Tsuyoshi
N1 - Funding Information:
The authors report no conflicts of interest related to this research. Dr. Esaki received manuscript fees from Dainippon Sumitomo. Dr. Obayashi and Dr. Saeki received a research grant from YKK AP Inc., Ushio Inc., Tokyo Electric Power Company, EnviroLife Research Institute Co., Ltd., Sekisui Chemical Co., Ltd, LIXIL Corp., and KYOCERA Corp. Dr. Fujita received speaker's honoraria from Dainippon Sumitomo, Eli Lilly, GlaxoSmithKline, Janssen, Yoshitomi, Otsuka, Meiji, Shionogi, Novartis, and Kracie. Dr Iwata received speaker's honoraria from Astellas, Dainippon Sumitomo, Eli Lilly, GlaxoSmithKline, Janssen, Yoshitomi, Otsuka, Meiji, Shionogi, Novartis, and Pfizer and received research grants from GlaxoSmithKline, Meiji, Otsuka, Mitsubishi Tanabe, Dainippon Sumitomo, Daiichisankyo, and Eisai. Dr. Kitajima received speaker's honoraria from Eisai, Mitsubishi Tanabe, Otsuka, Takeda, Eli Lilly, MSD, Meiji, Yoshitomi, Fukuda, Dainippon Sumitomo, Shionogi, and Novo Nordisk and received a research grant from Eisai, MSD, and Takeda.
Funding Information:
We are grateful to the patients who participated in this study. We also thank Soji Tsuboi and Miyuki Yamamoto for their valuable support during this study. This work was supported by Scientific Research from JSPS KAKENHI (grant numbers: 18K15529 ), Japan Foundation for Neuroscience and Mental Health, and The Neuroscience Research Center.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Obesity and overweight are highly prevalent in individuals with bipolar disorder and are associated with a risk of developing not only physical but also mental problems. The current study aimed to determine the association between bedroom light exposure at night and obesity in individuals with bipolar disorder. This cross-sectional study enrolled 200 outpatients with bipolar disorder. The light intensity in the bedroom between bedtime and rising time was measured for seven consecutive nights using a portable photometer. Body mass index (BMI) was determined using self-reported height and weight, and obesity was defined as a BMI ≥ 25 kg/m2. The overall prevalence of obesity was 44%. In the multivariable logistic regression analysis adjusted for age, gender, use of psychiatric medications, sleep parameters, and physical activity, the odds ratio (OR) for obesity was significantly higher in the group exposed to an average light intensity ≥ 3 lux (n = 112) than in the group exposed to an average light intensity < 3 lux (n = 88) (OR, 2.13; 95% confidence interval, 1.19–4.21; P = 0.01). Furthermore, individuals exposed to an average light intensity ≥ 3 lux were significantly higher body weight (adjusted mean, 68.7 vs. 64.4 kg; P = 0.03) and BMI (adjusted mean, 25.6 vs. 24.2 kg/m2; P = 0.04) than those exposed to an average light intensity < 3 lux. A significant association was observed between bedroom light exposure at night and obesity in patients with bipolar disorder. Further longitudinal investigations are necessary to clarify this association.
AB - Obesity and overweight are highly prevalent in individuals with bipolar disorder and are associated with a risk of developing not only physical but also mental problems. The current study aimed to determine the association between bedroom light exposure at night and obesity in individuals with bipolar disorder. This cross-sectional study enrolled 200 outpatients with bipolar disorder. The light intensity in the bedroom between bedtime and rising time was measured for seven consecutive nights using a portable photometer. Body mass index (BMI) was determined using self-reported height and weight, and obesity was defined as a BMI ≥ 25 kg/m2. The overall prevalence of obesity was 44%. In the multivariable logistic regression analysis adjusted for age, gender, use of psychiatric medications, sleep parameters, and physical activity, the odds ratio (OR) for obesity was significantly higher in the group exposed to an average light intensity ≥ 3 lux (n = 112) than in the group exposed to an average light intensity < 3 lux (n = 88) (OR, 2.13; 95% confidence interval, 1.19–4.21; P = 0.01). Furthermore, individuals exposed to an average light intensity ≥ 3 lux were significantly higher body weight (adjusted mean, 68.7 vs. 64.4 kg; P = 0.03) and BMI (adjusted mean, 25.6 vs. 24.2 kg/m2; P = 0.04) than those exposed to an average light intensity < 3 lux. A significant association was observed between bedroom light exposure at night and obesity in patients with bipolar disorder. Further longitudinal investigations are necessary to clarify this association.
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U2 - 10.1016/j.physbeh.2020.113281
DO - 10.1016/j.physbeh.2020.113281
M3 - Article
AN - SCOPUS:85097767021
VL - 230
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
M1 - 113281
ER -